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Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways
Preman P, Alfonso-Triguero M, Alberdi E, Verkhratsky A, Arranz AM.. Cells, 2021-03-04
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Astrocytes perform a wide variety of essential functions defining normal operation of the nervous system and are active contributors to the pathogenesis of neurodegenerative disorders such as Alzheimer's among others. Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease. The advent of transcriptomics technologies enables rapid progress in the characterisation of such pathological astrocyte states.
What this study adds
Evidence grade: Low
This is a narrative review. This review describes evidence that distinct astrocyte states are associated with specific stages of Alzheimer's disease and that transcriptomics technologies enable rapid progress in characterizing these states. It is a review of pathological astrocyte states and does not report a treatment, cure, or prevention.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Preman, P., Alfonso-Triguero, M., Alberdi, E., Verkhratsky, A., & Arranz, A. M. (2021). Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways. Cells. https://doi.org/10.3390/cells10030540
Vancouver
Preman P, Alfonso-Triguero M, Alberdi E, Verkhratsky A, Arranz AM. Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways. Cells. 2021. doi:10.3390/cells10030540. PMID: 33806259.
BibTeX
@article{preman2021-33806259,
author = {Preman, P. and Alfonso-Triguero, M. and Alberdi, E. and Verkhratsky, A. and Arranz, A. M.},
title = {{Astrocytes in Alzheimer's Disease: Pathological Significance and Molecular Pathways}},
journal = {Cells},
year = {2021},
doi = {10.3390/cells10030540},
pmid = {33806259},
url = {https://doi.org/10.3390/cells10030540}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Recent data provide compelling evidence that distinct astrocyte states are associated with specific stages of Alzheimer´s disease.
- The advent of transcriptomics technologies enables rapid progress in the characterisation of such pathological astrocyte states.
- In this review, we provide an overview of the origin, main functions, molecular and morphological features of astrocytes in physiological as well as pathological conditions related to Alzheimer´s disease.
- We will also explore the main roles of astrocytes in the pathogenesis of Alzheimer´s disease and summarize main transcriptional changes and altered molecular pathways observed in astrocytes during the course of the disease.
Why it matters
This review describes evidence that distinct astrocyte states are associated with specific stages of Alzheimer's disease and that transcriptomics technologies enable rapid progress in characterizing these states. It is a review of pathological astrocyte states and does not report a treatment, cure, or prevention.
Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cells) |
| Journal's citation record | 2 / 4 | Cells: journal h-index 234 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 180 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 25.7 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 4 / 6 | Cited 13.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 3 / 4 | Cited 110 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Amaia M. Arranz: h-index 19 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | KU Leuven: institution h-index 1,386 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 3 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33806259) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
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