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Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity
Cummings BJ, Cotman CW.. Lancet (London, England), 1995-12-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
The protein beta-amyloid is said to be central to the disease process of Alzheimer's disease (AD). Several groups have developed transgenic models that overexpress the amyloid precursor protein or beta-amyloid and then develop AD-like neuropathology. Another report suggests that beta-amyloid accumulation in old dogs correlates with cognitive impairment.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cummings, B. J., & Cotman, C. W. (1995). Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet (London, England). https://doi.org/10.1016/s0140-6736(95)92053-6
Vancouver
Cummings BJ, Cotman CW. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet (London, England). 1995. doi:10.1016/s0140-6736(95)92053-6. PMID: 7491048.
BibTeX
@article{cummings1995-7491048,
author = {Cummings, B. J. and Cotman, C. W.},
title = {{Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity}},
journal = {Lancet (London, England)},
year = {1995},
doi = {10.1016/s0140-6736(95)92053-6},
pmid = {7491048},
url = {https://doi.org/10.1016/s0140-6736(95)92053-6}
}
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Key findings
- Several groups have developed transgenic models that overexpress the amyloid precursor protein or beta-amyloid and then develop AD-like neuropathology.
- Another report suggests that beta-amyloid accumulation in old dogs correlates with cognitive impairment.
- However, many other researchers argue that beta-amyloid deposition in senile plaques is a secondary event because plaque numbers in man do not correlate well with cognition.
- We set out to analyse this conumdrum in man.
Why it matters
This study analyzed beta-amyloid load in human brain tissue and its relation to dementia severity, noting that plaque numbers do not correlate well with cognition. It examines the role of amyloid in the disease process and does not test any treatment, cure or prevention.
Study details
- Study designcross-sectional
- Participants16
- Evidence strengthLow
How this study scored 54/100
Published in a top-tier journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 10 / 10 | Tier 1 — top-tier general journal (Lancet (London, England)) |
| Journal's citation record | 4 / 4 | The Lancet: journal h-index 1,205 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 1 / 4 | 16 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 263 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 8.0 citations a year over 33 year(s) since 1995 |
| Impact for its field and year | 4 / 6 | Cited 10.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Carl W. Cotman: h-index 166 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of California, Irvine: institution h-index 1,195 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7491048) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 54 / 100 | — |
What each of these 20 components measures, and what this score is not →
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