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Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
Cummings BJ, Pike CJ, Shankle R, Cotman CW.. Neurobiology of aging, 1996-11-01
Topic: Amyloid, tau and blood-test diagnosis
The relationship between progressive cognitive decline and underlying neuropathology associated with Alzheimer s disease (AD) is a key issue in defining the mechanisms responsible for functional loss. This has been a subject of much controversy, with separate studies comparing various clinical and neuropathological indices in AD. Further, it is difficult to compare studies with differences in histochemical staining protocols, brain regions examined, and data quantification criteria.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cummings, B. J., Pike, C. J., Shankle, R., & Cotman, C. W. (1996). Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiology of aging. https://doi.org/10.1016/s0197-4580(96)00170-4
Vancouver
Cummings BJ, Pike CJ, Shankle R, Cotman CW. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease. Neurobiology of aging. 1996. doi:10.1016/s0197-4580(96)00170-4. PMID: 9363804.
BibTeX
@article{cummings1996-9363804,
author = {Cummings, B. J. and Pike, C. J. and Shankle, R. and Cotman, C. W.},
title = {{Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease}},
journal = {Neurobiology of aging},
year = {1996},
doi = {10.1016/s0197-4580(96)00170-4},
pmid = {9363804},
url = {https://doi.org/10.1016/s0197-4580(96)00170-4}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- This has been a subject of much controversy, with separate studies comparing various clinical and neuropathological indices in AD.
- Further, it is difficult to compare studies with differences in histochemical staining protocols, brain regions examined, and data quantification criteria.
- There are many difficulties in designing a clinical-pathological correlative study involving AD patients.
- It is necessary to control for several key parameters.
Why it matters
This study examined the relationship between progressive cognitive decline and underlying neuropathology in Alzheimer's disease, including beta-amyloid deposition, while noting difficulties in comparing such clinical-pathological studies. It is about correlating brain pathology with cognitive status and does not test any treatment, cure or prevention.
Study details
- Participants20
- Evidence strengthLow
How this study scored 53/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1996 — older than 20 years, still counted |
| Sample size | 1 / 4 | 20 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 307 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.6 citations a year over 32 year(s) since 1996 |
| Impact for its field and year | 4 / 6 | Cited 8.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 22 other studies in this library |
| Still being cited | 1 / 4 | Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Carl W. Cotman: h-index 166 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | Harvard University: institution h-index 3,235 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 9363804) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 53 / 100 | — |
What each of these 20 components measures, and what this score is not →
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