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Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients
Zhao Q, Liu M, Ha L, Zhou Y, Alzheimer's Disease Neuroimaging Initiative.. Frontiers in neurology, 2019-05-15
Topic: Amyloid, tau and blood-test diagnosis
18 F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18 F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups ( p < 0.01). Although there was an increasing tendency of 18 F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18 F-AV1451 deposition was found between CN and MCI brains with or without PVC ( p > 0.05). Declined MMSE score was observed with increasing 18 F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18 F-AV1451 deposition. PVC improved the results of 18 F-AV-1451 tau deposition and correlation studies in small brain regions. The typical deposition of 18 F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18 F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18 F-AV1451 tau PET quantification.
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APA 7th
Zhao, Q., Liu, M., Ha, L., Zhou, Y., & Alzheimer's Disease Neuroimaging Initiative. (2019). Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients. Frontiers in neurology. https://doi.org/10.3389/fneur.2019.00486
Vancouver
Zhao Q, Liu M, Ha L, Zhou Y, Alzheimer's Disease Neuroimaging Initiative. Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients. Frontiers in neurology. 2019. doi:10.3389/fneur.2019.00486. PMID: 31156534.
BibTeX
@article{zhao2019-31156534,
author = {Zhao, Q. and Liu, M. and Ha, L. and Zhou, Y. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients}},
journal = {Frontiers in neurology},
year = {2019},
doi = {10.3389/fneur.2019.00486},
pmid = {31156534},
url = {https://doi.org/10.3389/fneur.2019.00486}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- 18 F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions.
- Most regional SUVRs showed significantly higher uptake of 18 F-AV1451 in AD than MCI and CN participants.
- SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups ( p < 0.01).
- Although there was an increasing tendency of 18 F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18 F-AV1451 deposition was found between CN and MCI brains with or without PVC ( p > 0.05).
- Declined MMSE score was observed with increasing 18 F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform.
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Study details
- Participants115
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 29 of the 58 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 115 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31156534) |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 58 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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