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Serum amyloid beta protein in young and elderly depression: a pilot study
Kita Y, Baba H, Maeshima H, Nakano Y, Suzuki T, Arai H.. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2009-12-01
Topic: Amyloid, tau and blood-test diagnosis
Background Depression may increase the risk of developing Alzheimer's disease (AD). Recent large cohort studies have also shown that a low plasma amyloid beta (Abeta)-42 level combined with a high Abeta40 level increases the risk of developing AD, suggesting plasma Abeta42/40 ratio as useful for identifying risk of developing mild cognitive impairment and AD. Although several studies have examined Abeta levels in the peripheral blood of elderly individuals with depression, results have been inconsistent. Furthermore, no results have been described for younger depression. Methods Serum Abeta40, Abeta42 level and Abeta40/42 ratio were evaluated using enzyme-linked immunosorbent assay in 60 patients with major depressive disorder (MDD) and 60 healthy controls. The results were analyzed in two age groups (young, <60 years; elderly, >or=60 years). Results Serum Abeta40 level was significantly higher in young MDD patients compared to young controls (P < 0.001), but it was not significantly deferent in the elderly group. Serum Abeta42 level did not differ significantly in both young and elderly groups. Abeta40/42 ratio was significantly higher in both young (P < 0.001) and elderly (P < 0.001) patients with MDD compared to controls. Conclusions Serum Abeta40/42 ratio was significantly higher in MDD patients than in controls, and this difference was seen for both elderly and young subjects. This may suggest that even young subjects with MDD undergo pathological changes in the very early stage of amyloid deposition.
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APA 7th
Kita, Y., Baba, H., Maeshima, H., Nakano, Y., Suzuki, T., & Arai, H. (2009). Serum amyloid beta protein in young and elderly depression: a pilot study. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. https://doi.org/10.1111/j.1479-8301.2009.00293.x
Vancouver
Kita Y, Baba H, Maeshima H, Nakano Y, Suzuki T, Arai H. Serum amyloid beta protein in young and elderly depression: a pilot study. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2009. doi:10.1111/j.1479-8301.2009.00293.x. PMID: 20377819.
BibTeX
@article{kita2009-20377819,
author = {Kita, Y. and Baba, H. and Maeshima, H. and Nakano, Y. and Suzuki, T. and Arai, H.},
title = {{Serum amyloid beta protein in young and elderly depression: a pilot study}},
journal = {Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society},
year = {2009},
doi = {10.1111/j.1479-8301.2009.00293.x},
pmid = {20377819},
url = {https://doi.org/10.1111/j.1479-8301.2009.00293.x}
}
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Key findings
- Recent large cohort studies have also shown that a low plasma amyloid beta (Abeta)-42 level combined with a high Abeta40 level increases the risk of developing AD, suggesting plasma Abeta42/40 ratio as useful for identifying risk of developing mild cognitive impairment and AD.
- Although several studies have examined Abeta levels in the peripheral blood of elderly individuals with depression, results have been inconsistent.
- Furthermore, no results have been described for younger depression.
- The results were analyzed in two age groups (young, <60 years; elderly, >or=60 years).
- Results Serum Abeta40 level was significantly higher in young MDD patients compared to young controls (P < 0.001), but it was not significantly deferent in the elderly group.
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Study details
- Study designcohort study
- Participants60
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2009 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 60 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20377819) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 34 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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