Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change
Soldan A, Pettigrew C, Cai Q, Wang MC, Moghekar AR, O'Brien RJ, Selnes OA, Albert MS et al.. JAMA neurology, 2016-06-01
Topic: Amyloid, tau and blood-test diagnosis
Results Two hundred twenty-two cognitively normal participants were included in the analyses (mean follow-up, 11.0 years [range, 0-18.3 years] and mean baseline age, 56.9 years [range, 22.1-85.8 years]). The APOE ε4 genotype was not associated with baseline cognitive composite score or the rate of change in the cognitive composite score. Conclusions and relevance These results suggest that, to optimize observing a treatment effect, clinical trials enrolling cognitively normal individuals should selectively recruit participants with abnormal levels of both amyloid and tau (ie, stage 2) because this group would be expected to show the greatest cognitive decline over time if untreated.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Soldan, A., Pettigrew, C., Cai, Q., Wang, M. C., Moghekar, A. R., O'Brien, R. J., et al. (2016). Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change. JAMA neurology. https://doi.org/10.1001/jamaneurol.2016.0194
Vancouver
Soldan A, Pettigrew C, Cai Q, Wang MC, Moghekar AR, O'Brien RJ, et al. Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change. JAMA neurology. 2016. doi:10.1001/jamaneurol.2016.0194. PMID: 27064267.
BibTeX
@article{soldan2016-27064267,
author = {Soldan, A. and Pettigrew, C. and Cai, Q. and Wang, M. C. and Moghekar, A. R. and O'Brien, R. J. and Selnes, O. A. and Albert, M. S. and others},
title = {{Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change}},
journal = {JAMA neurology},
year = {2016},
doi = {10.1001/jamaneurol.2016.0194},
pmid = {27064267},
url = {https://doi.org/10.1001/jamaneurol.2016.0194}
}
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Key findings
- Results Two hundred twenty-two cognitively normal participants were included in the analyses (mean follow-up, 11.0 years [range, 0-18.3 years] and mean baseline age, 56.9 years [range, 22.1-85.8 years]).
- The APOE ε4 genotype was not associated with baseline cognitive composite score or the rate of change in the cognitive composite score.
- Conclusions and relevance These results suggest that, to optimize observing a treatment effect, clinical trials enrolling cognitively normal individuals should selectively recruit participants with abnormal levels of both amyloid and tau (ie, stage 2) because this group would be expected to show the greatest cognitive decline over time if untreated.
Why it matters
In 222 cognitively normal participants followed for a mean of 11 years, APOE ε4 genotype was not associated with baseline cognitive score or rate of cognitive change. The authors suggest that clinical trials should recruit participants with abnormal levels of both amyloid and tau to observe the greatest cognitive decline.
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Study details
- Study designcohort study
- Evidence strengthModerate
How this study scored 58/100
Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 120 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 10.0 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 12.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 2 / 4 | Cited 27 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Marilyn Albert: h-index 89 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 27064267) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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Read the original
- DOI: 10.1001/jamaneurol.2016.0194
- PubMed: 27064267
- Original source →
- Free full text: PubMed Central →
Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).
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