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Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study
Zuurbier LA, Ikram MA, Luik AI, Hofman A, Van Someren EJ, Vernooij MW, Tiemeier H.. European journal of neurology, 2015-07-24
Topic: Brain proteins, microglia and lab models
Background and purpose Cerebral small vessel disease is common in elderly persons. Patients with dementia or stroke frequently have cerebral small vessel disease and often experience disturbances in the sleep-wake rhythm. It is unknown whether cerebral small vessel disease is related to disturbances in sleep and 24-h activity rhythms.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Zuurbier, L. A., Ikram, M. A., Luik, A. I., Hofman, A., Van Someren, E. J., Vernooij, M. W., et al. (2015). Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study. European journal of neurology. https://doi.org/10.1111/ene.12775
Vancouver
Zuurbier LA, Ikram MA, Luik AI, Hofman A, Van Someren EJ, Vernooij MW, et al. Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study. European journal of neurology. 2015. doi:10.1111/ene.12775. PMID: 26206535.
BibTeX
@article{zuurbier2015-26206535,
author = {Zuurbier, L. A. and Ikram, M. A. and Luik, A. I. and Hofman, A. and Van Someren, E. J. and Vernooij, M. W. and Tiemeier, H.},
title = {{Cerebral small vessel disease is related to disturbed 24-h activity rhythms: a population-based study}},
journal = {European journal of neurology},
year = {2015},
doi = {10.1111/ene.12775},
pmid = {26206535},
url = {https://doi.org/10.1111/ene.12775}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Patients with dementia or stroke frequently have cerebral small vessel disease and often experience disturbances in the sleep-wake rhythm.
- It is unknown whether cerebral small vessel disease is related to disturbances in sleep and 24-h activity rhythms.
- Methods This study was conducted in the Rotterdam Study.
- A total of 970 community-dwelling persons (mean age 59.2 years) underwent brain magnetic resonance imaging and actigraphy.
Why it matters
This population-based study investigated whether cerebral small vessel disease is related to disturbed sleep and 24-hour activity rhythms. It does not show that treating small vessel disease or sleep problems prevents or treats Alzheimer's disease.
Study details
- Participants970
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of neurology) |
| Journal's citation record | 2 / 4 | European Journal of Neurology: journal h-index 181 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 970 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 56 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.3 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 3 / 6 | Cited 7.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Henning W. Tiemeier: h-index 144 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26206535) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
What each of these 20 components measures, and what this score is not →
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