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Research

27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 1–21 of 21 studies by Witteman JC · 27,380 in the whole library · How the 0–100 score works

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Other authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 12,859 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

Smoking and risk of dementia and Alzheimer's disease in a population-based cohort study: the Rotterdam Study

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Lancet (London, England) 1998-06-01

During mean follow-up of 2.1 (range 1.5-3.4) years, 146 incident cases of dementia were detected, of which 105 were Alzheimer's disease. 3 key findings →

Design: case-control study Participants: 6,870 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Diet and risk of dementia: Does fat matter?: The Rotterdam Study

✓ Peer-reviewed alzhub usefulness score 65 out of 100. Neurology 2002-12-01

High intake of total, saturated, and trans fat and cholesterol and low intake of MUFA, PUFA, n-6 PUFA, and n-3 PUFA were not associated with increased risk of dementia or its subtypes. 4 key findings →

Design: cohort study Participants: 5,395 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Dietary antioxidants and long-term risk of dementia

✓ Peer-reviewed alzhub usefulness score 64 out of 100. Archives of neurology 2010-07-01

The Rotterdam Study previously found that higher dietary intakes of vitamins E and C related to lower risk of dementia and Alzheimer disease (AD) over 6 years of follow-up. 4 key findings →

Design: cohort study Participants: 5,395 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Hypertension and cerebral white matter lesions in a prospective cohort study

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Brain : a journal of neurology 2002-04-01

White matter lesions are frequently found on cerebral MRI scans of elderly people and are thought to be important in the pathogenesis of dementia. 5 key findings →

Design: cross-sectional Participants: 1,077 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Dietary fatty acids and the risk of Parkinson disease: the Rotterdam study

✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2005-06-01

Unsaturated fatty acids are important constituents of neuronal cell membranes and have neuroprotective, antioxidant, and anti-inflammatory properties. 4 key findings →

Design: cohort study Participants: 5,289 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease

✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neurology 2006-07-01

Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson disease (PD), through neurotoxic effects. 4 key findings →

Design: cohort study Participants: 5,289 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease

✓ Peer-reviewed alzhub usefulness score 57 out of 100. Stroke 2008-03-06

Men, but not women, with unrecognized myocardial infarction (MI) have an increased risk of cardiac events and stroke compared with those without MI or with recognized MI. 4 key findings →

Design: cohort study Participants: 613 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Dietary intake of fish and omega-3 fatty acids in relation to long-term dementia risk

✓ Peer-reviewed alzhub usefulness score 55 out of 100. The American journal of clinical nutrition 2009-05-27

Greater fish and omega-3 (n-3) polyunsaturated fatty acid (PUFA) intake may reduce dementia risk; however, previous studies have reported conflicting results, which were largely based on short-term follow-up. 4 key findings →

Participants: 5,395 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Endogenous estradiol and risk of dementia in women and men: the Rotterdam Study

✓ Peer-reviewed alzhub usefulness score 53 out of 100. Annals of neurology 2003-05-01

We determined whether higher endogenous estradiol levels were associated with lower risk of dementia in older men and women not using hormonal replacement therapy, using a case-cohort design within the Rotterdam Study, a population-based follow-up study on chronic diseases, including dementia, in 7983 subjects aged 55 years or older, and ongoing since 1990. 4 key findings →

Participants: 7,983 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging

✓ Peer-reviewed alzhub usefulness score 49 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2012-04-25

Increasing evidence suggests a role of atherosclerosis in the pathogenesis of cognitive impairment and dementia. 4 key findings →

Participants: 844 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed