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Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease
European Alzheimer’s & Dementia Biobank Mendelian Randomization (EADB-MR) Collaboration, Luo J, Thomassen JQ, Bellenguez C, Grenier-Boley B, de Rojas I, Castillo A, Parveen K et al.. JAMA network open, 2023-05-01
Topic: Amyloid, tau and blood-test diagnosis
Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk factors throughout the life course. However, robust evidence for most of these risk factors is lacking. Effective interventions should target risk factors in the causal pathway to dementia.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Luo, J., Thomassen, J. Q., Bellenguez, C., Grenier-Boley, B., de Rojas, I., Castillo, A., et al. (2023). Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease. JAMA network open. https://doi.org/10.1001/jamanetworkopen.2023.13734
Vancouver
Luo J, Thomassen JQ, Bellenguez C, Grenier-Boley B, de Rojas I, Castillo A, et al. Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease. JAMA network open. 2023. doi:10.1001/jamanetworkopen.2023.13734. PMID: 37195665.
BibTeX
@article{luo2023-37195665,
author = {Luo, J. and Thomassen, J. Q. and Bellenguez, C. and Grenier-Boley, B. and de Rojas, I. and Castillo, A. and Parveen, K. and others},
title = {{Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease}},
journal = {JAMA network open},
year = {2023},
doi = {10.1001/jamanetworkopen.2023.13734},
pmid = {37195665},
url = {https://doi.org/10.1001/jamanetworkopen.2023.13734}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- However, robust evidence for most of these risk factors is lacking.
- Effective interventions should target risk factors in the causal pathway to dementia.
- Objective To comprehensively disentangle potentially causal aspects of modifiable risk factors for Alzheimer disease (AD) to inspire new drug targeting and improved prevention.
- Design, setting, and participants This genetic association study was conducted using 2-sample univariable and multivariable mendelian randomization.
Why it matters
This genetic analysis aimed to identify which modifiable risk factors are causally linked to Alzheimer's disease to guide prevention and drug targeting. It is an analysis of genetic associations and does not report a treatment, cure, or proven prevention.
Study details
- Participants39
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA network open) |
| Journal's citation record | 2 / 4 | JAMA Network Open: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 1 / 4 | 39 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 91 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 18.2 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 4 / 6 | Cited 16.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 82 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ruth Frikke‐Schmidt: h-index 65 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Oxford: institution h-index 2,205 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 133 institution(s) in 19 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37195665) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1001/jamanetworkopen.2023.13734
- PubMed: 37195665
- Original source →
- Free full text: JAMA Network Open →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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