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Experimental models of vascular dementia and vascular cognitive impairment: a systematic review
Jiwa NS, Garrard P, Hainsworth AH.. Journal of neurochemistry, 2010-10-07
Topic: Risk, prevention and care in population studies
Vascular cognitive impairment (VCI) encompasses vascular dementia and is the second most common cause of dementing illness after Alzheimer's disease. The main causes of VCI are: cerebral small vessel disease; multi-infarct dementia; strategic infarct (i.e. located in a functionally-critical brain area); haemorrhage/microbleed; angiopathy (including cerebral amyloid angiopathy); severe hypoperfusion (e.g. cardiac arrhythmia); and hereditary vasculopathy (e.g. cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL). In this systematic analysis, we aimed to relate cognitive and neuropathological features of experimental models to clinical VCI.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Jiwa, N. S., Garrard, P., & Hainsworth, A. H. (2010). Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. Journal of neurochemistry. https://doi.org/10.1111/j.1471-4159.2010.06958.x
Vancouver
Jiwa NS, Garrard P, Hainsworth AH. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review. Journal of neurochemistry. 2010. doi:10.1111/j.1471-4159.2010.06958.x. PMID: 20731763.
BibTeX
@article{jiwa2010-20731763,
author = {Jiwa, N. S. and Garrard, P. and Hainsworth, A. H.},
title = {{Experimental models of vascular dementia and vascular cognitive impairment: a systematic review}},
journal = {Journal of neurochemistry},
year = {2010},
doi = {10.1111/j.1471-4159.2010.06958.x},
pmid = {20731763},
url = {https://doi.org/10.1111/j.1471-4159.2010.06958.x}
}
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Key findings
- The main causes of VCI are: cerebral small vessel disease; multi-infarct dementia; strategic infarct (i.e. located in a functionally-critical brain area); haemorrhage/microbleed; angiopathy (including cerebral amyloid angiopathy); severe hypoperfusion (e.g. cardiac arrhythmia); and hereditary vasculopathy (e.g. cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, CADASIL).
- In this systematic analysis, we aimed to relate cognitive and neuropathological features of experimental models to clinical VCI.
- We extracted data from 107 studies covering 16 models.
- These included: brief global ischaemic insults (in rats, mice or gerbils); chronic global hypoperfusion (rats, mice, gerbils); chronic hypertension (in primates or stroke-prone, spontaneously-hypertensive rats); multiple ischaemic lesions because of intra-vascular emboli (in rodents, rabbits or primates); strategic ischaemic lesions (in rats or mini-pigs); generalised vasculopathies, because of mutant Notch3, hyperhomocysteinaemia, experimental diabetes mellitus or lack of cerebral vasodilator M(5) receptors (rats or mice).
Why it matters
This systematic review related cognitive and neuropathological features of experimental models to clinical vascular cognitive impairment, extracting data from 107 studies covering 16 models. It is a review of animal and experimental models and does not test a treatment, cure, or prevention in people.
Study details
- Evidence strengthLow
How this study scored 52/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurochemistry) |
| Journal's citation record | 3 / 4 | Journal of Neurochemistry: journal h-index 349 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A systematic review of all the studies on the question (from PubMed type “Systematic Review”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | 5 / 7 | Cited 255 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.2 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 1 / 6 | Cited 0.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 2 / 4 | Cited 31 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Atticus H. Hainsworth: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | St George's, University of London: institution h-index 762 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20731763) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 52 / 100 | — |
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