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white-matter
905 studies tagged white-matter, dated 1975-09-01 to 2026-09-14. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease 2026-09-14
- Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study 2026-09-07
- Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study 2026-09-01
Studies
905 studies carry this tag.
Date range
1975 to 2026
Top journals
- Neurology 93
- Stroke 61
- Alzheimer s & Dementia 31
- Brain : a journal of neurology 20
- Annals of neurology 19
342 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Cerebellar volumetric changes are intricately linked to aging, with distinct patterns across its transverse zones, the functional subdivisions characterized by unique cytoarchitectural and connectivity profiles.
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White matter hyperintensities (WMH) are neuroimaging markers linked to an elevated risk of cognitive decline.
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Vascular contributions to cognitive impairment and dementia (VCID) represent a major public health challenge in the aging population, with age-related cerebromicrovascular dysfunction playing a critical role in its development.
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These dysregulations are associated with malfunctions in multiple signaling pathways or disrupted mechanical cellular responses.
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Regular voluntary exercise has been shown to increase waste transport through the glymphatic system in mice.
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Traumatic brain injury (TBI) has been linked to the development of neurodegenerative diseases, particularly Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE).
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WMH shape is associated with long-term risk for dementia after 10 years in community-dwelling older adults.
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Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) contribute to vascular cognitive impairment and dementia (VCID), with aging and hypertension being key risk factors.
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MASLD was significantly associated with smaller volumes of total grey matter and subcortical grey matter (p < 0.05) and reduced Alzheimer's disease (AD)-signature cortical thickness (multivariable-adjusted β = -0.04; 95% confidence interval [CI]: -0.07, -0.01).
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Both V3 width and plasma Hcy concentration were negatively correlated with MoCA scores in PD (r=-0.358, P<0.001; r=-0.187, P=0.013, respectively).
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In linear mixed models, vascular endothelial growth factor was significantly associated with incident DWI-positive lesions over 1 year.
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= 0.71) longitudinally. YKL-40 associations with FW and FW-corrected fractional anisotropy were null.
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Cerebral small vessel disease (SVD) is recognized as a major vascular contributor to cognitive decline, ultimately leading to dementia and stroke.
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Population-based evidence directly linking liver diseases to brain disorders is limited, and its genetic and biochemical associations remain unclear.
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Marchiafava-Bignami disease (MBD) is a rare toxic-based demyelinating disease that affects the central nervous system.
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WMHs in the frontoparietal and anterior periventricular region were associated with blood pressure traits, WMH genetic risk score (GRS), baseline and decline in general cognitive performance, incident all-cause dementia, and ischemic stroke.
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CAA may be encountered as an isolated pathology or with Alzheimer disease and has been demonstrated to be associated with an increased risk of seizures.
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Mean age was 83.5 years (delirium 78.7 vs non-delirium 88.4); 13/20 were female; 17/20 had premorbid cognitive decline/impairment or dementia.
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Cerebral small vessel disease (cSVD) is a common cause of stroke and dementia.
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Chronic cerebral hypoperfusion can lead to neuronal necrosis, trigger inflammatory responses, promote white matter damage, and ultimately result in cognitive impairment.
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For diverse neurodegenerative disorders, microglial cells are activated.
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The results of gene set enrichment and gene set variation analyses indicated that immune-related pathways were upregulated in patients with VaD.
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Vascular cognitive impairment (VCI) is a leading cause of age-related cognitive decline, driven by cerebrovascular dysfunction and cerebral small vessel disease (CSVD).
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Cerebrovascular disease is associated with an increased likelihood of developing dementia.
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Our findings indicate that liver fat mediates associations between cardiometabolic factors and WMHs and that WMHs mediate the association between liver fat and cognitive performance.
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Alzheimer's disease (AD) is the leading cause of dementia, characterized by the accumulation of amyloid-beta (Aβ) and neurofibrillary tangles.
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Prevention of dementia represents a public health priority.
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In particular, the severity of HIV-associated neurocognitive disorders (HAND) has been greatly reduced, significantly decreasing the prevalence of HIV-associated dementia [1].
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The final model, which included age, systolic blood pressure >140, atrial fibrillation, and tobacco use, achieved an AUC of 0.83 (95% CI 0.75-0.90) in the development cohort (N=143, 62.4±12.6 years, 44% female, 36% non-white race) and 0.85 (95% CI 0.77-0.92) in the validation cohort (N=127, 65.2±16.8 years, 51% female, 34% non-white race), with similar results using WMH measurements derived from cMRI (N=120, p=0.98, AUC=0.86, 95% CI 0.77-0.93).
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Small extracellular vesicles (sEVs), including exosomes as a subtype, with a diameter typically less than 200 nm and originating from the endosomal system, are capable of transporting a diverse array of bioactive molecules, including proteins, nucleic acids, and lipids, thereby facilitating intercellular communication and modulating cellular functions.
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59/100
We identified 1143 dementia-free individuals with acute stroke during follow-up: 1061 (92.8%) ischemic, 82 (7.2%) hemorrhagic, 49.9% female, and 30.8% Black.
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Genetic variants increase the risk of neurocognitive disorders in later life, including vascular dementia (VaD) and Alzheimer’s disease (AD), but the precise relationships between genetic risk factors and underlying disease etiologies are not well understood.
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Among 4712 participants (59% female; mean age, 74 years), 193 ischemic strokes and 769 dementia cases were ascertained over a median follow-up of 8.3 years.
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Dietary intake moderated the association between several cSVD biomarkers and MoCA scores such that the expected negative association between cSVD biomarkers and cognition was seen at low levels of healthy dietary intake, but not at medium or high levels.
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According to the World Health Organization (WHO), peripheral and central neurological disorders affect approximately one billion people worldwide.
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Metabolic syndrome markers, such as insulin resistance and the triglyceride/HDL C ratio, correlate with early cognitive impairment.
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Stroke is the leading cause of acquired disability.
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The results of the inverse variance weighted analysis demonstrate a significant positive causal relationship between stroke and VaD (OR = 2.06, 95% confidence interval [CI] = 1.17-3.61, P = .01).
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= 0.120). These findings suggest that DESH and high EI, often considered biomarkers for iNPH, may lack specificity and may be found in a subset of patients with PSP or LBD leading to unnecessary neurosurgery for iNPH.
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This raises the suggestion that a decreased neurovascular coupling in the disease process of AD is related to comorbid small vessel disease.
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Based on the fusion of the topological features of the multimodal FBN and SBN, the accuracy for the diagnosis of MCI in patients with unilateral MCA steno-occlusive disease reached 90.00%.
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55/100
Of 104 metabolites studied, glycodeoxycholic acid (GDCA) surpassed the false discovery rate and was associated the Alzheimer's Disease Assessment Scale-Cognitive Subscale version 13 (ADAS-Cog13) score (β = 0.12, 95 % CI = 0.05-0.20, p = 0.001) and cognitive impairment determined by mini-mental status exam (MMSE) (OR = 2.11, 95 % CI = 1.41-3.15, p < 0.001).
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BackgroundThe clinical significance of enlarged perivascular spaces (EPVS) in Alzheimer' s disease (AD) was ambiguous.
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There are many reports about the comorbidity of NPH and other neurodegenerative diseases1–3; the primary findings in neuropathological studies of patients with NPH include amyloid plaques and hyperphosphorylated tau protein inclusions.2,4 This suggests that proteinopathy may be one of the potential causes of NPH.
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MAFLD was associated with an increased risk of WMH over 4.1 years in middle‐aged adults.
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One hundred ninety-eight of 229 participants had WMH volumes available at both time-points.
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In this review, we outline the significant roles of necroptosis and its molecular mechanisms in the pathological process of VaD, with a particular focus on the role of necroptosis in modulating neuroinflammation and exacerbating the disruption of BBB permeability in VaD, and elaborate on the molecular regulatory mechanisms and the centrally involved cells of necroptosis mediated by tumor necrosis factor-α in neuroinflammation in VaD.
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246 older adults (mean age = 58.84 ± 7.00 years; 38.21 % males) were included in our data analysis.
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We identified 13 meaningful resting-state networks, and the dFNC among them derived four states exhibiting different connection patterns.
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Combining co-pathology markers may identify individuals with a high risk of cognitive decline.
From across this tag
10 of the 904 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias
- Nitric oxide signaling in brain function, dysfunction, and dementia
- Effect of Intensive Systolic Blood Pressure Control on Markers of Cerebral Small Vessel Disease by Age
- Geographic variation of epilepsy for older Americans: How close to the geographic variation of stroke?
- Research criteria for subcortical vascular dementia in clinical trials
- Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease
- Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality: the Framingham Offspring Study
- The Association Between Possible Sarcopenia and Delirium Onset in Older Patients With Acute Stroke
- Diffusion tensor MRI correlates with executive dysfunction in patients with ischaemic leukoaraiosis
- Targeting the neural extracellular matrix in neurological disorders