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Home › Research › Topic

Plasma and spinal-fluid biomarkers

1,573 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 1,573 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2017 Biomarkers

    The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-β (Aβ) concentration was investigated.

  2. Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2017 Tau biomarkers

    In EDAR and DESCRIPA test data, inclusion of a case/control PGRS was no more predictive of Aβ, and a combined Aβ and tau endpoint than the basic models (accuracies of 66.0%, and 73.3% respectively).

  3. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-10-27 Tau biomarkers

    This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1-42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia.

  4. Ocular indicators of Alzheimer's: exploring disease in the retina

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2016-09-19 Brain scans and imaging

    Although historically perceived as a disorder confined to the brain, our understanding of Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with mounting evidence of abnormalities in the eye.

  5. 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain : a journal of neurology 2016-06-29 Brain scans and imaging

    Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem.

  6. Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature communications 2016-06-21 Tau biomarkers

    Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective.

  7. Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Radiology 2016-05-31 Vascular contributions

    The results of this study showed global BBB leakage in patients with early AD that is associated with cognitive decline.

  8. Melanopsin retinal ganglion cell loss in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Annals of neurology 2015-12-18 Brain scans and imaging

    We show variable degrees of rest-activity circadian dysfunction in AD patients.

  9. The pattern of amyloid accumulation in the brains of adults with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2015-09-09 Down syndrome and Alzheimer's

    PIB binding in DS, first appearing in striatum, began around age 40 and was strongly associated with dementia and cognitive decline.

  10. Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Biomarkers

    We have further demonstrated the association of PPY and IgM with NAB, despite technical differences between studies.

  11. Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. ACS chemical neuroscience 2014-08-13 Biomarkers

    Recent advances in biomarkers provide the possibility of early or preclinical diagnosis of Alzheimer's pathology.

  12. Amyloid PET imaging in Alzheimer's disease: a comparison of three radiotracers

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. European journal of nuclear medicine and molecular imaging 2014-03-20 Brain scans and imaging

    Despite differing white and grey matter retention characteristics, cortical retention for each (18)F tracer was highly correlated with that of PiB, enabling conversion of thresholds across tracer measurement scales with a high level of internal consistency.

  13. Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2013-04-11 Treatments

    These data suggest that vascular leakage events, such as microhemorrhage, may be related to the removal of vascular Aβ.

  14. Retinal nerve fiber layer thickness in patients with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2013-03-01 Brain scans and imaging

    The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) without visual impairment using spectral domain optical coherence tomography (SD-OCT) and to compare the results with healthy controls.

  15. Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biochemical pharmacology 2013-01-03 Biomarkers

    The disturbances of the cholesterol synthesis and metabolism described in Alzheimer's disease (AD) may be both a consequence of the neurodegenerative process and a contributor to the pathogenesis.

  16. Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current Alzheimer research 2012-10-01 Biomarkers

    Different authors described that transthyretin (TTR) is decreased in the cerebrospinal fluid (CSF) of Alzheimer's disease (AD) patients and thus TTR is a potential CSF biomarker in AD.

  17. The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Current Alzheimer research 2010-08-01 Biomarkers

    The CSF Abeta42/Abeta40 ratio improves differentiation of AD patients from VaD, DLB and non-AD dementia patients, when compared to Abeta42 alone, and is a more easily interpretable alternative to the combination of Abeta42, p-tau and t-tau when differentiating AD from either FTD or non-AD dementia.

  18. Blood-based neurochemical diagnosis of vascular dementia: a pilot study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurochemistry 2007-07-27 Biomarkers

    Blood-based tests for the differential diagnosis of Alzheimer's disease (AD) are under intensive investigation and have shown promising results with regard to Abeta40 and Abeta42 peptide species in incipient AD.

  19. Retinal abnormalities in early Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Investigative ophthalmology & visual science 2007-05-01 Brain scans and imaging

    Retinal abnormalities in early AD include a specific pattern of RNFL loss, narrow veins, and decreased retinal blood flow in these veins.

  20. Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2006-07-01 Biomarkers

    Our results support further efforts to prospectively validate the use of Q Abeta42/p-tau as a biomarker to discriminate between AD and VaD.

  21. 3alpha,5alpha-THP: a potential plasma neurosteroid biomarker in Alzheimer's disease and perhaps non-Alzheimer's dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Psychopharmacology 2005-10-18 Biomarkers

    Lowered 3alpha,5alpha-THP levels appear promising as a biomarker in dementia, but further work is needed to establish the sensitivity and specificity of these findings in AD.

  22. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2005-02-04 Tau biomarkers

    The recently developed ultrasensitive bio-barcode assay was used to measure the concentration of amyloid-beta-derived diffusible ligands (ADDLs), a potential soluble pathogenic Alzheimer's disease (AD) marker, in the cerebrospinal fluid (CSF) of 30 individuals.

  23. Intrathecal inflammation precedes development of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurology, neurosurgery, and psychiatry 2003-09-01 Tau biomarkers

    These results demonstrate increased production of the proinflammatory cytokine, TNFalpha and decreased production of the anti-inflammatory cytokine TGFbeta in patients with MCI at risk to develop AD, suggesting a propensity towards inflammation in this patient group and indicating that CNS inflammation is a early hallmark in the pathogenesis of AD.

  24. Amyloidosis: a convoluted story

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. British Journal of Haematology 2001-09-01 Drug development

    However, the fibrils in primary amyloidosis (AL) consist of the variable portion of a monoclonal light chain (κ or λ); secondary amyloidosis (AA) fibrils consist of protein A, a non-immunoglobulin; familial amyloidosis fibrils are usually composed of mutated transthyretin (prealbumin); senile systemic amyloid fibrils consist of normal transthyretin; and amyloid associated with long-term dialysis consists of β2-microglobulin.

  25. Coexistence of Alzheimer-type neuropathology in Creutzfeldt-Jakob disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 1998-08-01 Drug development

    Creutzfeldt-Jakob disease (CJD) and Alzheimer's disease (AD) share clinical, neuropathological, and pathogenetic features.

From across this topic

9 of the 1,573 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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