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Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration
Jamie Toombs, Martha S Foiani, Ross W Paterson, Amanda Heslegrave, Selina Wray, Jonathan M Schott, Nick C Fox, Michael P Lunn et al.. Journal of Alzheimer's disease : JAD, 2017
Topic: Plasma and spinal-fluid biomarkers
The effect of spinal manometers on cerebrospinal fluid (CSF) amyloid-β (Aβ) concentration was investigated. Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube. CSF was analyzed for Aβ38/40/42 using an electrochemiluminescence immunoassay. Relative to control, use of a manometer decreased Aβ38/40/42 concentration by 5.6% (±1.5SE), 4.4% (±1.7SE), and 4.3% (±2.4SE), respectively. The ratios of Aβ42 :40, Aβ42 :38, and Aβ40 :38 were not affected by manometer treatment. Factors which artificially lower CSF Aβ concentrations are relevant to clinical diagnosis for AD and study design.
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APA 7th
Toombs, J., Foiani, M. S., Paterson, R. W., Heslegrave, A., Wray, S., Schott, J. M., et al. (2017). Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-161126
Vancouver
Toombs J, Foiani MS, Paterson RW, Heslegrave A, Wray S, Schott JM, et al. Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration. Journal of Alzheimer's disease : JAD. 2017. doi:10.3233/jad-161126. PMID: 28059797.
BibTeX
@article{toombs2017-28059797,
author = {Toombs, Jamie and Foiani, Martha S and Paterson, Ross W and Heslegrave, Amanda and Wray, Selina and Schott, Jonathan M and Fox, Nick C and Lunn, Michael P and others},
title = {{Effect of Spinal Manometers on Cerebrospinal Fluid Amyloid-β Concentration}},
journal = {Journal of Alzheimer's disease : JAD},
year = {2017},
doi = {10.3233/jad-161126},
pmid = {28059797},
url = {https://doi.org/10.3233/jad-161126}
}
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Key findings
- Pooled human CSF samples were divided in two, one half passed through a manometer into a collection tube, the other transferred directly to a collection tube.
- CSF was analyzed for Aβ38/40/42 using an electrochemiluminescence immunoassay.
- Relative to control, use of a manometer decreased Aβ38/40/42 concentration by 5.6% (±1.5SE), 4.4% (±1.7SE), and 4.3% (±2.4SE), respectively.
- The ratios of Aβ42 :40, Aβ42 :38, and Aβ40 :38 were not affected by manometer treatment.
- Factors which artificially lower CSF Aβ concentrations are relevant to clinical diagnosis for AD and study design.
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Study details
- Effect size5.6%; 4.4%; 4.3%
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 24 of the 56 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2017 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28059797) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 24 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 24 of the 56 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
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