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Home › Research › Topic

Plasma and spinal-fluid biomarkers

1,573 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Association of the top 20 Alzheimer's disease risk genes with [18F]flortaucipir PET

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2022-05-11 Brain scans and imaging

    APOE ε4 showed significant (P < .05) associations with tau deposition across all disease stages.

  2. Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2021-12-22 Tau biomarkers

    The (pre-)analytical procedures were similar between centers.

  3. Normal cerebrospinal fluid concentrations of PDGFRβ in patients with cerebral amyloid angiopathy and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2021-12-07 Tau biomarkers

    PDGFRβ levels were similar in CAA patients and controls (P = .78) and in aMCI/AD clinical phenotype and controls (P = .91). aMCI/AD patients with an AD+ biomarker profile (A+T+[N+]) had increased PDGFRβ levels compared to (A-T-[N-]) controls (P = .006).

  4. Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica communications 2021-11-18 Brain scans and imaging

    Alzheimer's disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning.

  5. Evaluation of [18F]PI-2620, a second-generation selective tau tracer, for assessing four-repeat tauopathies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain communications 2021-08-24 Brain scans and imaging

    To assess the ability of [18F]PI-2620 to detect regional tau burden in non-Alzheimer's disease tauopathies compared with Alzheimer's disease, patients with progressive supranuclear palsy (n = 3), corticobasal syndrome (n = 2), corticobasal degeneration (n = 1) or Alzheimer's disease (n = 8), and healthy controls (n = 7) were recruited.

  6. Automated production of [18F]Flortaucipir for PET imaging of tauopathies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. American journal of nuclear medicine and molecular imaging 2021-06-15 Brain scans and imaging

    Radiotracer [18F]Flortaucipir is an FDA-approved diagnostic agent for PET imaging of density and distribution of abnormal tau protein deposition (tauopathies) in Alzheimer's disease.

  7. Interaction of amyloid and tau on cortical microstructure in cognitively unimpaired adults

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2021-05-13 Tau biomarkers

    We observed a significant CSF Aβ42 /Aβ40 × p-tau interaction on cortical neurite density index (NDI), but not orientation dispersion index or cortical thickness.

  8. Haemodynamic impairment along the Alzheimer's disease continuum

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. European journal of neurology 2021-04-23 Tau biomarkers

    The breath-holding index was reduced in the AD continuum and was inversely correlated to CSF amyloid β42 levels.

  9. ADAM10: Biomarker of mild cognitive impairment but not of cognitive frailty

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Experimental gerontology 2021-03-03 Biomarkers

    Mild cognitive impairment (MCI) associated with physical frailty gave rise to the new concept of cognitive frailty.

  10. Retinal imaging in Alzheimer's and neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-10-08 Brain scans and imaging

    In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly.

  11. Blood-based biomarkers for Alzheimer's pathology and the diagnostic process for a disease-modifying treatment: Projecting the impact on the cost and wait times

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2020-08-18 Biomarkers

    The combination BBBM with MMSE is projected to increase the efficiency and value of the triage process for DMT eligibility.

  12. Amyloid beta, tau, synaptic, neurodegeneration, and glial biomarkers in the preclinical stage of the Alzheimer's continuum

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-06-23 Biomarkers

    Multiple biological pathways are altered and could be targeted very early in the Alzheimer's continuum.

  13. Cerebral amyloid angiopathy with focal presentation-about 3 cases

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuroradiology 2020-05-15 Vascular contributions

    Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline.

  14. Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-01-01 Brain scans and imaging

    We demonstrate for the first time a link between MBI and early AD pathology in a cognitively intact elderly population, supporting the use of the MBI-C as a metric to enhance clinical trial enrolment.

  15. Plasma amyloid beta levels are associated with cerebral amyloid and tau deposition

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2019-07-26 Biomarkers

    Plasma Aβ measures may be useful biomarkers for predicting cerebral Aβ and tau.

  16. Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2019-05-15 Digital health tools

    Neuropathologists assess vast brain areas to identify diverse and subtly-differentiated morphologies.

  17. Aβ and tau structure-based biomarkers for a blood- and CSF-based two-step recruitment strategy to identify patients with dementia due to Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2019-03-12 Biomarkers

    The primary Aβ-based blood biomarker funnels individuals with suspected AD for subsequent validation of the diagnosis by structure-based combined analysis of the CSF biomarkers Aβ and tau.

  18. Retinal Microvascular and Neurodegenerative Changes in Alzheimer's Disease and Mild Cognitive Impairment Compared with Control Participants

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Ophthalmology. Retina 2019-03-11 Brain scans and imaging

    Alzheimer's participants showed significantly reduced macular VD, PD, and GC-IPL thickness compared with MCI and controls.

  19. Entorhinal cortex tau, amyloid-β, cortical thickness and memory performance in non-demented subjects

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain 2019-01-20 Brain scans and imaging

    As more biomarkers for Alzheimer's disease and age-related brain conditions become available, more sophisticated analytic approaches are needed to take full advantage of the information they convey.

  20. Ultrasensitive Detection of Plasma Amyloid-β as a Biomarker for Cognitively Normal Elderly Individuals at Risk of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of Alzheimer's disease : JAD 2019-01-01 Biomarkers

    Plasma Aβ ratios in this study are a potential biomarker for brain Aβ deposition and therefore, for preclinical AD.

  21. Parametric methods for [18F]flortaucipir PET

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2018-12-20 Brain scans and imaging

    [18F]Flortaucipir is a PET tau tracer used to visualize tau binding in Alzheimer's disease (AD) in vivo.

  22. Steroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Oxford medical case reports 2018-09-24 Tau biomarkers

    Being treatable, steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto's encephalopathy, should be distinguished from untreatable conditions.

  23. Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's research & therapy 2017-12-15 Biomarkers

    Plasma levels of Aβ oligomers could be assessed using MDS, which might be a simple, noninvasive, and accessible assay for evaluating brain amyloid deposition related to AD pathology.

  24. Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. JCI insight 2017-08-17 Brain scans and imaging

    The geometric distribution and increased burden of retinal amyloid pathology in AD, together with the feasibility to noninvasively detect discrete retinal amyloid deposits in living patients, may lead to a practical approach for large-scale AD diagnosis and monitoring.

  25. Evaluation of glymphatic system activity with the diffusion MR technique: diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Alzheimer's disease cases

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Japanese journal of radiology 2017-02-14 Brain scans and imaging

    Activity of the glymphatic system may be evaluated with diffusion images.

From across this topic

10 of the 1,573 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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