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Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau
Benjamin J Kim, Vivian Lee, Edward B Lee, Adrienne Saludades, John Q Trojanowski, Joshua L Dunaief, Murray Grossman, David J Irwin. Acta neuropathologica communications, 2021-11-18
Topic: Plasma and spinal-fluid biomarkers
Alzheimer's disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning. In contrast, we have seen outer retina thinning driven by photoreceptor outer nuclear layer (ONL) thinning with antemortem optical coherence tomography (OCT) among patients considered to have a frontotemporal degeneration tauopathy (FTLD-Tau). Our objective was to determine if postmortem retinal tissue from FTLD-Tau patients demonstrates ONL loss observed antemortem on OCT. Two probable FTLD-Tau patients that were deeply phenotyped by clinical and genetic testing were imaged with OCT and followed to autopsy. Postmortem brain and retinal tissue were evaluated by a neuropathologist and ocular pathologist, respectively, masked to diagnosis. OCT findings were correlated with retinal histology. The two patients had autopsy-confirmed FTLD-Tau neuropathology and had antemortem OCT measurements showing ONL thinning (66.9 μm, patient #1; 74.9 μm, patient #2) below the 95% confidence interval of normal limits (75.1-120.7 μm) in our healthy control cohort. Postmortem, retinal tissue from both patients demonstrated loss of nuclei in the ONL, matching ONL loss visualized on antemortem OCT. Nuclei counts from each area of ONL loss (2 - 3 nuclei per column) seen in patient eyes were below the 95% confidence interval (4 - 8 nuclei per column for ONL) of 3 normal control retinas analyzed at the same location. Our evaluation of retinal tissue from FTLD-Tau patients confirms ONL loss seen antemortem by OCT. Continued investigation of ONL thinning as a biomarker that may distinguish FTLD-Tau from other dementias is warranted.
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APA 7th
Kim, B. J., Lee, V., Lee, E. B., Saludades, A., Trojanowski, J. Q., Dunaief, J. L., et al. (2021). Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau. Acta neuropathologica communications. https://doi.org/10.1186/s40478-021-01290-8
Vancouver
Kim BJ, Lee V, Lee EB, Saludades A, Trojanowski JQ, Dunaief JL, et al. Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau. Acta neuropathologica communications. 2021. doi:10.1186/s40478-021-01290-8. PMID: 34794500.
BibTeX
@article{kim2021-34794500,
author = {Kim, Benjamin J and Lee, Vivian and Lee, Edward B and Saludades, Adrienne and Trojanowski, John Q and Dunaief, Joshua L and Grossman, Murray and Irwin, David J},
title = {{Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau}},
journal = {Acta neuropathologica communications},
year = {2021},
doi = {10.1186/s40478-021-01290-8},
pmid = {34794500},
url = {https://doi.org/10.1186/s40478-021-01290-8}
}
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Key findings
- Alzheimer's disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning.
- Postmortem, retinal tissue from both patients demonstrated loss of nuclei in the ONL, matching ONL loss visualized on antemortem OCT.
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Study details
- Evidence strengthModerate
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Acta neuropathologica communications) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34794500) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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