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Haemodynamic impairment along the Alzheimer's disease continuum
Marina Diomedi, Alessandro Rocco, Chiara Giuseppina Bonomi, Alfredo Paolo Mascolo, Vincenzo De Lucia, Federico Marrama, Fabrizio Sallustio, Giacomo Koch et al.. European journal of neurology, 2021-04-23
Topic: Plasma and spinal-fluid biomarkers
The breath-holding index was reduced in the AD continuum and was inversely correlated to CSF amyloid β42 levels. Such correlation was stronger in the A+T+ than in the A+T- group, and unexpectedly reached statistical significance only in the E3 and not in the E4 genotype carriers. These results suggest a tight and effective relationship between amyloid β42, vascular hypoperfusion, cerebrovascular reactivity and epsilon genotype.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Diomedi, M., Rocco, A., Bonomi, C. G., Mascolo, A. P., De Lucia, V., Marrama, F., et al. (2021). Haemodynamic impairment along the Alzheimer's disease continuum. European journal of neurology. https://doi.org/10.1111/ene.14834
Vancouver
Diomedi M, Rocco A, Bonomi CG, Mascolo AP, De Lucia V, Marrama F, et al. Haemodynamic impairment along the Alzheimer's disease continuum. European journal of neurology. 2021. doi:10.1111/ene.14834. PMID: 33759296.
BibTeX
@article{diomedi2021-33759296,
author = {Diomedi, Marina and Rocco, Alessandro and Bonomi, Chiara Giuseppina and Mascolo, Alfredo Paolo and De Lucia, Vincenzo and Marrama, Federico and Sallustio, Fabrizio and Koch, Giacomo and others},
title = {{Haemodynamic impairment along the Alzheimer's disease continuum}},
journal = {European journal of neurology},
year = {2021},
doi = {10.1111/ene.14834},
pmid = {33759296},
url = {https://doi.org/10.1111/ene.14834}
}
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Key findings
- The breath-holding index was reduced in the AD continuum and was inversely correlated to CSF amyloid β42 levels.
- Such correlation was stronger in the A+T+ than in the A+T- group, and unexpectedly reached statistical significance only in the E3 and not in the E4 genotype carriers.
- These results suggest a tight and effective relationship between amyloid β42, vascular hypoperfusion, cerebrovascular reactivity and epsilon genotype.
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Study details
- Evidence strengthModerate
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 25 of the 56 points we could judge it on, which is 45 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (European journal of neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33759296) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 25 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 25 of the 56 points we could judge it on is 45 out of 100. |
| Total | 45 / 100 | — |
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