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Newest in this topic

  1. Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study 2026-03-31
  2. Neighborhood environmental deprivation predicts the generalized neurocognitive deficit in schizophrenia 2025-12-19
  3. Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC? 2025-12-01

Studies

492 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Neurology 38
  • Biological psychiatry 36
  • NeuroImage 32
  • The American journal of psychiatry 22
  • Proceedings of the National Academy of Sciences of the United States of America 20

148 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Baseline predictors of rates of hippocampal atrophy in mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. Neurology 2007-10-01 Brain scans and imaging

    Rates of hippocampal atrophy (%/year) were 0.0 +/- 0.8 in the absent, 1.7 +/- 0.4 in the moderate, and 3.6 +/- 1.0 in the severe (mean +/- SD) tertile.

  2. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neurology, neurosurgery, and psychiatry 2007-09-10 Cognitive tests and assessment

    25 older individuals with MCI performed a visual scene encoding task during fMRI scanning, and were followed clinically for at least 4 years after scanning.

  3. The role of hippocampus in the pathophysiology of bipolar disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Behavioural pharmacology 2007-09-01 Hippocampus size on brain scans

    Bipolar disorder (BD) is thought to be associated with abnormalities within discrete brain regions associated with emotional regulation, particularly in fronto-limbic-subcortical circuits.

  4. Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Biological psychiatry 2007-08-28 Hippocampus size on brain scans

    These findings support evidence of genetic control of brain volume even in adults, particularly of hippocampal and neocortical volume and of cortical volumetric reductions being familial, but do not support measures of subcortical volumes per se as representing intermediate biologic phenotypes.

  5. Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: a longitudinal MRI study

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Psychopharmacology 2007-08-20 Hippocampus size on brain scans

    Consistent with preclinical literature supporting the neuroprotective effects of lithium, long-term treatment is associated with preservation of recollective memory function and increased hippocampal size in vivo.

  6. Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Biological psychiatry 2007-08-08 Hippocampus size on brain scans

    Our findings confirm and extend previous voxel-based morphometry analyses in ill subjects with schizophrenia.

  7. What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European archives of psychiatry and clinical neuroscience 2007-08-01 Hippocampus size on brain scans

    Even though in vivo imaging studies document significant reductions of hippocampal volume in depressed patients, the exact underlying cellular mechanisms are unclear.

  8. Amygdala and hippocampal volumes in familial early onset major depressive disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 2007-07-20 Hippocampus size on brain scans

    Reduced hippocampal volume may be suggestive of a risk factor for developing MDD.

  9. Longitudinal MRI and cognitive change in healthy elderly

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neuropsychology 2007-07-01 Hippocampus size on brain scans

    Cross-sectional studies of normal aging indicate an association between memory and hippocampal volume, and between executive functioning and subcortical-frontal circuits.

  10. The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain and cognition 2007-04-26 Hippocampus size on brain scans

    In this review, we report on studies that have assessed the effects of exogenous and endogenous increases in stress hormones on human cognitive performance.

  11. Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2007-04-04 Hippocampus size on brain scans

    Most previous magnetic resonance imaging (MRI) studies of patients with bipolar disorder (BD) report similar hippocampus (HC) volumes across patients and controls, but because patients studied were heterogeneous with respect to course of illness variables and medication status, the conclusions of these studies remain equivocal.

  12. The associations among hippocampal volume, cortisol reactivity, and memory performance in healthy young men

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Psychiatry research 2007-03-28 Hippocampus size on brain scans

    In aged and pathological populations, reduced hippocampal volume is frequently described in association with impairment of hippocampus-dependent cognitive processes and chronically elevated cortisol levels.

  13. Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2007-03-13 Hippocampus size on brain scans

    The s allele variant of the serotonin transporter gene (5-HTT) has recently been observed to moderate the relationship of stress to depression and anxiety.

  14. Brain volumes in relatives of patients with schizophrenia: a meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Archives of general psychiatry 2007-03-01 Hippocampus size on brain scans

    Brain abnormalities are present in nonpsychotic first-degree relatives of patients with schizophrenia and are most pronounced in the hippocampus.

  15. Maternal care modulates the relationship between prenatal risk and hippocampal volume in women but not in men

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2007-03-01 Hippocampus size on brain scans

    Smaller hippocampal volume is associated with psychiatric disorders.

  16. Stress predicts brain changes in children: a pilot longitudinal study on youth stress, posttraumatic stress disorder, and the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Pediatrics 2007-03-01 Hippocampus size on brain scans

    Additional studies seem to be warranted.

  17. Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Diabetologia 2007-02-14 Hippocampus size on brain scans

    These results suggest that the medial temporal lobe may be the first brain site affected by type 2 diabetes and that individuals in poorer metabolic control may be affected to a greater extent.

  18. Prospective reports of chronic life stress predict decreased grey matter volume in the hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2007-02-01 Hippocampus size on brain scans

    Chronic stress in non-human animals decreases the volume of the hippocampus, a brain region that supports learning and memory and that regulates neuroendocrine activity.

  19. Hippocampal hypometabolism predicts cognitive decline from normal aging

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurobiology of aging 2007-01-11 Getting a diagnosis

    Hippocampal MRglc reductions using FDG-PET during normal aging predict cognitive decline years in advance of the clinical diagnosis.

  20. Spatial memory and hippocampal volume in humans with unilateral vestibular deafferentation

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Hippocampus 2007-01-01 Hippocampus size on brain scans

    Patients with acquired chronic bilateral vestibular loss were recently found to have a significant impairment in spatial memory and navigation when tested with a virtual Morris water task.

  21. Hippocampal sclerosis dementia differs from hippocampal sclerosis in frontal lobe degeneration

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2006-12-30 Disease mechanisms

    Hippocampal sclerosis (HS) is characterized by selective neuronal loss and gliosis in CA1 and the subiculum and has been associated with several disorders, including Alzheimer's disease, frontotemporal lobar degeneration with ubiquitin immunoreactive inclusions (FTLD-U), vascular dementia and some tauopathies.

  22. Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurotoxicology and teratology 2006-12-12 Hippocampus size on brain scans

    Aberrations in hippocampal asymmetry and left hippocampal volumes were found for adolescent heavy drinkers.

  23. Hippocampal volume is as variable in young as in older adults: implications for the notion of hippocampal atrophy in humans

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. NeuroImage 2006-11-21 Hippocampus size on brain scans

    Previous studies in humans have shown the presence of an age-related reduction of hippocampal (HC) volume, as well as the presence of reduced HC volume in psychiatric populations suffering from schizophrenia, depression or post-traumatic stress disorder.

  24. MRI of hippocampus and entorhinal cortex in mild cognitive impairment: a follow-up study

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neurobiology of aging 2006-11-13 Mild cognitive impairment

    The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia.

  25. Hippocampus volume loss due to chronic heavy drinking

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Alcoholism, clinical and experimental research 2006-11-01 Hippocampus size on brain scans

    These data support the view that heavy drinking exerts a unique and selectively injurious effect on the hippocampus.

  26. Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2006-10-13 Hippocampus size on brain scans

    Antidepressants protect against hippocampal volume loss in humans and reverse stress-induced atrophic changes in animals thus supporting the hypothesis that the pathophysiology of stress-related disorders such as depression involves reductions in neuronal connectivity and this effect is reversible by antidepressant treatment.

  27. Hippocampal volume reduction and HPA-system activity in major depression

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Journal of psychiatric research 2006-10-04 Hippocampus size on brain scans

    Structural imaging studies investigating hippocampal volumes in patients suffering from major depression have yielded mixed results.

  28. 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 2006-10-03 Hippocampus size on brain scans

    Alzheimer's disease is the most common neurodegenerative disorder in the elderly.

  29. Reduced hippocampal volume correlates with executive dysfunctioning in major depression

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of psychiatry & neuroscience : JPN 2006-09-01 Hippocampus size on brain scans

    The present findings emphasize that patients with reduced hippocampal volumes show more executive dysfunctions than their counterparts.

  30. Extrahippocampal contributions to age differences in human spatial navigation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cerebral cortex (New York, N.Y. : 1991) 2006-07-20 Hippocampus size on brain scans

    The hippocampus (HC) and associated neural structures are hypothesized to contribute to individual differences in human spatial navigation.

  31. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2006-07-07 Hippocampus size on brain scans

    Ts65Dn, a well-characterized animal model for Down syndrome, has three copies of the distal end of mouse chromosome 16 and therefore has segmental trisomy for orthologs for nearly half of the genes located on human chromosome 21.

  32. Hippocampal disconnection contributes to memory dysfunction in individuals at risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2006-06-19 Hippocampus size on brain scans

    The concept of amnestic mild cognitive impairment (MCI) describes older people who show a decline predominantly in memory function, but who do not meet criteria for dementia.

  33. Brain volume in first-episode schizophrenia: systematic review and meta-analysis of magnetic resonance imaging studies

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. The British journal of psychiatry : the journal of mental science 2006-06-01 Hippocampus size on brain scans

    Average volumetric changes are close to the limit of detection by MRI methods.

  34. A meta-analysis of structural brain abnormalities in PTSD

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Neuroscience and biobehavioral reviews 2006-05-26 Hippocampus size on brain scans

    This series of meta-analyses examined structural abnormalities of the hippocampus and other brain regions in persons with PTSD compared to trauma-exposed and non-exposed control groups.

  35. Cognitive abnormalities in post-traumatic stress disorder

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in cognitive sciences 2006-05-12 Hippocampus size on brain scans

    Characteristically arising in response to overwhelmingly terrifying events, post-traumatic stress disorder (PTSD) is a disorder of memory: sufferers seemingly relive their trauma in the form of involuntary recollection.

  36. Hippocampal and amygdalar volumes in dissociative identity disorder

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The American journal of psychiatry 2006-04-01 Hippocampus size on brain scans

    The findings are consistent with the presence of smaller hippocampal and amygdalar volumes in patients with dissociative identity disorder, compared with healthy subjects.

  37. The aging hippocampus: a multi-level analysis in the rat

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2006-03-29 Hippocampus size on brain scans

    In the current experiment we conducted a multi-level analysis of age-related characteristics in the hippocampus of young adult (3 months), middle-aged (12 months), and old (24 months) Fisher 344xBrown Norway hybrid (FBNF1) rats.

  38. Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The American journal of psychiatry 2006-03-01 Hippocampus size on brain scans

    Schizophrenia and psychotic bipolar disorder are characterized by morphometric distinctions in ventricular and hippocampal regions.

  39. Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2006-02-08 Hippocampus size on brain scans

    From clinical studies it is known that recurrent depressive episodes associate with a reduced hippocampal volume.

  40. Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Archives of general psychiatry 2006-02-01 Hippocampus size on brain scans

    Patients with chronic schizophrenia displayed bilateral hippocampal volume reduction.

  41. BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biological psychiatry 2006-01-25 Hippocampus size on brain scans

    In spite of a relatively small sample size, the presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region.

  42. Fornix integrity and hippocampal volume in male schizophrenic patients

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biological psychiatry 2006-01-10 Hippocampus size on brain scans

    These findings demonstrate a disruption in fornix integrity in patients with schizophrenia.

  43. Protective and damaging effects of stress mediators: central role of the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Dialogues in clinical neuroscience 2006-01-01 Hippocampus size on brain scans

    The mind involves the whole body and two-way communication between the brain and the cardiovascular, immune, and other systems via neural and endocrine mechanisms.

  44. Traumatic stress: effects on the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Dialogues in clinical neuroscience 2006-01-01 Hippocampus size on brain scans

    Brain areas implicated in the stress response include the amygdala, hippocampus, and prefrontal cortex.

  45. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Archives of general psychiatry 2006-01-01 Brain scans and imaging

    Atrophy of the hippocampus and amygdala on MRI in cognitively intact elderly people predicts dementia during a 6-year follow-up.

  46. Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2005-12-14 Hippocampus size on brain scans

    Analysis of post-mortem tissue from patients with affective disorders has revealed a decreased number of glial cells in several brain areas.

  47. Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of neurology, neurosurgery, and psychiatry 2005-11-23 Hippocampus size on brain scans

    Hippocampal atrophy is not only a characteristic of Alzheimer's disease but also occurs in FTLD.

  48. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of general psychiatry 2005-11-01 Hippocampus size on brain scans

    Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions.

  49. Central obesity and the aging brain

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Archives of neurology 2005-10-01 Hippocampus size on brain scans

    A larger WHR may be related to neurodegenerative, vascular, or metabolic processes that affect brain structures underlying cognitive decline and dementia.

  50. Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience research 2005-10-01 Hippocampus size on brain scans

    Daily restraint for 3 weeks was shown to atrophy dendrites of hippocampal pyramidal neurons in rats.

From across this tag

6 of the 492 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 6. The same 6 appear here every time.

All topic tags with their study counts