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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Insulin in the brain: there and back again

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacology & therapeutics 2012-07-17 Risk factors

    Insulin performs unique functions within the CNS.

  2. Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. British journal of pharmacology 2012-07-01 Drug development

    Like type-2 diabetes mellitus (T2DM), neurodegenerative disorders and stroke are an ever increasing, health, social and economic burden for developed Westernized countries.

  3. Exercise counteracts declining hippocampal function in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2012-06-30 Prevention trials

    Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified.

  4. Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicity research 2012-06-28 Brain scans and imaging

    The pineal product melatonin has remarkable antioxidant properties.

  5. Mitochondria, oxidative stress and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of the neurological sciences 2012-06-04 Disease mechanisms

    Mitochondria are involved in ATP supply to cells through oxidative phosphorylation (OXPHOS), synthesis of key molecules and response to oxidative stress, as well as in apoptosis.

  6. Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2012-05-15 Drug development

    Type 2 diabetes mellitus is a risk factor of Alzheimer's disease (AD), most likely linked to an impairment of insulin signaling in the brain.

  7. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of clinical investigation 2012-04-01 Genetics

    While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not been demonstrated directly in that disorder.

  8. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of clinical investigation 2012-04-01 Drug development

    Defective brain insulin signaling has been suggested to contribute to the cognitive deficits in patients with Alzheimer's disease (AD).

  9. Elevated oxidative stress and decreased antioxidant function in the human hippocampus and frontal cortex with increasing age: implications for neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurochemical research 2012-03-30 Biomarkers

    Oxidative stress and mitochondrial damage are implicated in the evolution of neurodegenerative diseases.

  10. Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacology, biochemistry, and behavior 2012-03-09 Drug development

    Diabetes increases the risk of Alzheimer's disease (AD).

  11. Cognitive impairment and vitamin B12: a review

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. International psychogeriatrics 2012-01-06 Drug development

    Low serum vitamin B12 levels are associated with neurodegenerative disease and cognitive impairment.

  12. Omega-3 fatty acids EPA and DHA: health benefits throughout life

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Advances in nutrition (Bethesda, Md.) 2012-01-05 Brain scans and imaging

    Omega-3 [(n-3)] fatty acids have been linked to healthy aging throughout life.

  13. GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Reviews in the neurosciences 2011-12-21 Drug development

    As a constitutively active kinase, glycogen synthase kinase 3 (GSK3) is a kinase which regulates body metabolism by phosphorylation of glycogen synthase (GS) and other substrates.

  14. Age-associated chronic diseases require age-old medicine: role of chronic inflammation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Preventive medicine 2011-12-09 Prevention trials

    Most chronic diseases--such as cancer, cardiovascular disease (CVD), Alzheimer disease, Parkinson disease, arthritis, diabetes and obesity--are becoming leading causes of disability and death all over the world.

  15. Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European journal of pharmacology 2011-11-12 Drug development

    Type 2 diabetes is a risk factor for Alzheimer's disease.

  16. Zinc and human health: an update

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of toxicology 2011-11-10 Genetics

    The importance of micronutrients in health and nutrition is undisputable, and among them, zinc is an essential element whose significance to health is increasingly appreciated and whose deficiency may play an important role in the appearance of diseases.

  17. Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cellular physiology 2011-10-01 Prevention and risk

    Glutamate is an essential excitatory neurotransmitter regulating brain functions.

  18. From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2011-09-28 Clinical safety

    Glutamate is the primary excitatory neurotransmitter in mammalian brain.

  19. A pathophysiological framework of hippocampal dysfunction in ageing and disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neuroscience 2011-09-07 Risk factors

    The hippocampal formation has been implicated in a growing number of disorders, from Alzheimer's disease and cognitive ageing to schizophrenia and depression.

  20. Purinergic signalling: from normal behaviour to pathological brain function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2011-09-01 Risk factors

    Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was first proposed in 1972.

  21. Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemical Society transactions 2011-08-01 Drug development

    Surprisingly little is known about the mechanisms that trigger the onset of AD (Alzheimer's disease) in sporadic forms.

  22. Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of nutrition 2011-08-01 Prevention and risk

    Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be obtained from the diet to sustain homeostasis.

  23. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Molecular aspects of medicine 2011-08-01 Disease mechanisms

    For the past 40 years or so, oxidative stress has been increasingly recognized as a contributing factor in aging and in various forms of pathophysiology generally associated with aging.

  24. A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of pineal research 2011-04-26 Risk factors

    The human pineal gland is a neuroendocrine transducer that forms an integral part of the brain.

  25. Linking lipids to Alzheimer's disease: cholesterol and beyond

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neuroscience 2011-03-30 Drug development

    Lipid-mediated signalling regulates a plethora of physiological processes, including crucial aspects of brain function.

From across this topic

9 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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