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Home › Research › Topic

Gut, metabolism and diet

1,048 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42)

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroscience letters 2008-08-22 Drug development

    Accumulation and deposition of amyloid beta peptide (Abeta) in the brain causes neuronal apoptosis and eventually leads to Alzheimer's disease (AD).

  2. Invited Article: Nervous system pathology in sporadic Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2008-05-12 Brain tissue and pathology

    Sporadic Parkinson disease (PD) is, after Alzheimer disease (AD), the second most frequent neurodegenerative disorder.1 The pathologic process in PD is progressive and takes years to reach its full extent.

  3. A mathematical model of glutathione metabolism

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Theoretical biology & medical modelling 2008-04-28 Down syndrome and Alzheimer's

    We show that the glutathione pools in hepatic cells and in the blood are quite insensitive to fluctuations in amino acid input and offer an explanation based on model predictions.

  4. Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer s Disease 2008-04-14 Genetics

    Intranasal insulin administration raises central nervous system (CNS) insulin levels in humans and acutely facilitates verbal memory in patients with Alzheimer's disease (AD), an effect that may differ by APOE genotype.

  5. Mitochondria take center stage in aging and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 2005-10-01 Disease mechanisms

    A critical role of mitochondrial dysfunction and oxidative damage has been hypothesized in both aging and neurodegenerative diseases.

  6. The impact of long-chainn-3 polyunsaturated fatty acids on human health

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nutrition Research Reviews 2005-06-01 Brain scans and imaging

    A considerable literature has been published on the health benefits of fish, oil-rich fish and fish oils and their constituent long-chain (LC) n-3 PUFA.

  7. Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of Neurology 2005-04-25 Disease mechanisms

    Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also occur in Alzheimer's disease (AD).

  8. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The American journal of clinical nutrition 2003-09-01 Prevention and risk

    Cardiovascular disease and cancer are ranked as the first and second leading causes of death in the United States and in most industrialized countries.

  9. The glutamatergic system and Alzheimer's disease: therapeutic implications

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. CNS drugs 2003-01-01 Treatments

    Alzheimer's disease affects nearly 5 million Americans currently and, as a result of the baby boomer cohort, is predicted to affect 14 million Americans and 22 million persons totally worldwide in just a few decades.

  10. Cholesterol and Alzheimer's disease: is there a link?

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2001-09-01 Drug development

    The Abeta-amyloid peptide (Abeta), the main component of amyloid plaques, is derived by proteolytic cleavage from the amyloid precursor protein (APP).

  11. Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. British journal of pharmacology 2001-05-01 Biomarkers

    1. beta-Amyloid peptide (A beta), a 39 -- 43 amino acid peptide, is believed to induce oxidative stress and inflammation in the brain, which are postulated to play important roles in the pathogenesis of Alzheimer's disease.

  12. Cholesterol metabolism in the brain

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Current opinion in lipidology 2001-04-01 Genetics

    The central nervous system accounts for only 2% of the whole body mass but contains almost a quarter of the unesterified cholesterol present in the whole individual.

  13. Lipid peroxidation products and antioxidants in human disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Environmental health perspectives 1998-10-01 Brain scans and imaging

    Lipid peroxidation (LPO) is a free radical-related process that in biologic systems may occur under enzymatic control, e.g., for the generation of lipid-derived inflammatory mediators, or nonenzymatically.

  14. Energy Thresholds in Brain Mitochondria

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 1998-05-01 Disease mechanisms

    Decreases in mitochondrial respiratory chain complex activities have been implicated in neurodegenerative disorders such as Parkinson's disease, Huntington's disease, and Alzheimer's disease.

  15. Neuroprotective strategy for Alzheimer disease: intranasal administration of a fatty neuropeptide

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 1996-01-09 Disease mechanisms

    Neurodegenerative diseases, in which neuronal cell disintegrate, bring about deteriorations in cognitive functions as is evidenced in millions of Alzheimer patients.

  16. Aging, energy, and oxidative stress in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1995-09-01 Disease mechanisms

    The etiology of neurodegenerative diseases remains enigmatic; however, evidence for defects in energy metabolism, excitotoxicity, and for oxidative damage is increasingly compelling.

  17. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1994-11-01 Disease mechanisms

    Oxidative damage to DNA may play a role in both normal aging and in neurodegenerative diseases.

  18. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of Neurology 1994-05-01 Disease mechanisms

    Glucose metabolism is depressed in the temporal and parietal regions of the cortex in patients with Alzheimer's disease.

  19. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain : a journal of neurology 1992-10-01 Tau biomarkers

    In contrast, no increases in CSF QUIN were found in chronic neurodegenerative disorders, depression or myoclonic seizure disorders, while CSF kynurenic acid concentrations were significantly lower in Huntington's disease and Alzheimer's disease.

  20. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1992-02-01 Disease mechanisms

    The etiology of nerve cell death in neuronal degenerative disease is unknown, but it has been hypothesized that excitotoxic mechanisms may play a role.

  21. Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1991-02-01 Tau biomarkers

    Quinolinic acid is an "excitotoxic" metabolite and an agonist of N-methyl-D-aspartate receptors.

  22. Sex Differences in the Gut-Brain Axis: Implications for Mental Health

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Current psychiatry reports 2020-11-20 Disease mechanisms

    The purpose of this article is to highlight how sex differences in the gut-brain axis may contribute to the discrepancies in incidence of neurodevelopmental, psychiatric, and neurodegenerative disorders between females and males.

  23. Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. The Journal of clinical investigation 2020-08-03 Risk factors

    Diabetes, obesity, and Alzheimer's disease (AD) are associated with vascular complications and impaired nitric oxide (NO) production.

  24. The Gut Microbiome as a Component of the Gut-Brain Axis in Cognitive Health

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Biological research for nursing 2020-07-17 Disease mechanisms

    Common themes in the current literature include GMB components; interactions on cognitive development; effects of GMB-gut-brain interactions on cognition, mild cognitive impairment and Alzheimer's disease; effects of GMB interactions with physiologic stress on cognition in critical care; and GMB modification for improved cognition.

  25. Preventive Role of L-Carnitine and Balanced Diet in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Nutrients 2020-07-03 Prevention and risk

    The prevention or alleviation of neurodegenerative diseases, including Alzheimer's disease (AD), is a challenge for contemporary health services.

From across this topic

10 of the 1,048 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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