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Association between serum cholesterol levels and Alzheimer's disease in China: a case-control study
Hui Chen, Yue Du, Shuai Liu, Baojin Ge, Yong Ji, Guowei Huang. International journal of food sciences and nutrition, 2019-01-09
Topic: Genetics and APOE
To examine the association between blood cholesterol concentrations and Alzheimer's disease (AD) in the Chinese elderly. A case-control study was implemented between November 2011 and November 2017. Elderly patients aged ≥ 55 years with (n = 117) and without AD (control participants; n = 117) were recruited from the Neurology Central Hospital of Tianjin, China. The associations between AD and blood parameters were assessed using multiple binary logistic regression analyses adjusted for multiple covariates. Higher serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels and lower serum high-density lipoprotein cholesterol (HDL-C) levels associated with AD risk in the models adjusted for (1) age, sex and education; and (2) further adjusted for body mass index, smoking status, stroke, hypertension, type 2 diabetes mellitus and heart disease. Increased serum TC and LDL-C levels and lower HDL-C levels were independently associated with the risk of AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Chen, H., Du, Y., Liu, S., Ge, B., Ji, Y., & Huang, G. (2019). Association between serum cholesterol levels and Alzheimer's disease in China: a case-control study. International journal of food sciences and nutrition. https://doi.org/10.1080/09637486.2018.1508426
Vancouver
Chen H, Du Y, Liu S, Ge B, Ji Y, Huang G. Association between serum cholesterol levels and Alzheimer's disease in China: a case-control study. International journal of food sciences and nutrition. 2019. doi:10.1080/09637486.2018.1508426. PMID: 30624122.
BibTeX
@article{chen2019-30624122,
author = {Chen, Hui and Du, Yue and Liu, Shuai and Ge, Baojin and Ji, Yong and Huang, Guowei},
title = {{Association between serum cholesterol levels and Alzheimer's disease in China: a case-control study}},
journal = {International journal of food sciences and nutrition},
year = {2019},
doi = {10.1080/09637486.2018.1508426},
pmid = {30624122},
url = {https://doi.org/10.1080/09637486.2018.1508426}
}
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Key findings
- Higher serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels and lower serum high-density lipoprotein cholesterol (HDL-C) levels associated with AD risk in the models adjusted for (1) age, sex and education; and (2) further adjusted for body mass index, smoking status, stroke, hypertension, type 2 diabetes mellitus and heart disease.
- Increased serum TC and LDL-C levels and lower HDL-C levels were independently associated with the risk of AD.
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Study details
- Study designcase-control study
- Participants117
- Evidence strengthModerate
How this study scored 63/100
Published in a peer-reviewed journal, and it is a case-control study. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 35 of the 56 points we could judge it on, which is 63 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of food sciences and nutrition) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 6 / 12 | A case-control study |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 117 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 30624122) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 35 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 35 of the 56 points we could judge it on is 63 out of 100. |
| Total | 63 / 100 | — |
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