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Home › Research › Topic

Genetics and APOE

933 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annual review of pathology 2021-08-30 Digital health tools

    Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder that involves dysregulation of many cellular and molecular processes.

  2. APOE Genotype and Alzheimer's Disease: The Influence of Lifestyle and Environmental Factors

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. ACS chemical neuroscience 2021-07-18 Risk factors

    Alzheimer's disease (AD) is the most common neurodegenerative disorder with obscure pathogenesis and no disease-modifying therapy to date.

  3. Plasma microRNA biomarker detection for mild cognitive impairment using differential correlation analysis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Biomarker research 2016-12-12 Biomarkers

    Differential correlation analysis, a bioinformatics tool to elucidate complicated and interdependent biological systems behind diseases, detects effective MCI markers that cannot be found by single molecule analysis such as t-test.

  4. Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7)

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Genes 2016-12-05 Brain scans and imaging

    Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to evolve.

  5. Towards understanding brain-gut-microbiome connections in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. BMC systems biology 2016-08-26 Risk factors

    Employing an integrated computational approach, we provide intriguing and supporting evidence for a role of microbial metabolites, an important modifiable environmental factor, in AD etiology.

  6. Whole-Genome Sequencing of a Healthy Aging Cohort

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cell 2016-04-21 Genetics

    Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease.

  7. Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. EMBO molecular medicine 2016-04-01 Drug development

    Apolipoprotein E receptor 2 (ApoER2) is an apolipoprotein E receptor involved in long-term potentiation, learning, and memory.

  8. Molecular genetics of early-onset Alzheimer's disease revisited

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-03-24 Genetics

    As the discovery of the Alzheimer's disease (AD) genes, APP, PSEN1, and PSEN2, in families with autosomal dominant early-onset AD (EOAD), gene discovery in familial EOAD came more or less to a standstill.

  9. The importance of understanding individual differences in Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. F1000Research 2016-03-23 Down syndrome and Alzheimer's

    In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature.

  10. Identification of Vulnerable Cell Types in Major Brain Disorders Using Single Cell Transcriptomes and Expression Weighted Cell Type Enrichment

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in neuroscience 2016-01-27 Genetics

    The cell types that trigger the primary pathology in many brain diseases remain largely unknown.

  11. Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Genome medicine 2016-01-19 Genetics

    We have characterized changes in DNA methylation in the superior temporal gyrus of patients with Alzheimer's disease, highlighting novel loci that facilitate better characterization of pathways and mechanisms underlying Alzheimer's disease pathogenesis, and improve our understanding of epigenetic signatures that may contribute to the development of disease.

  12. "Down syndrome: an insight of the disease"

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of biomedical science 2015-06-11 Down syndrome and Alzheimer's

    Down syndrome (DS) is one of the commonest disorders with huge medical and social cost.

  13. Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 2015-05-06 Genetics

    Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-TDP) is the most common pathology associated with frontotemporal dementia (FTD).

  14. Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature neuroscience 2015-03-24 Genetics

    Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative syndrome hallmarked by adult-onset loss of motor neurons.

  15. Convergent genetic and expression data implicate immunity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-12-20 Genetics

    The immune response, regulation of endocytosis, cholesterol transport, and protein ubiquitination represent prime targets for AD therapeutics.

  16. Role of early life exposure and environment on neurodegeneration: implications on brain disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Translational neurodegeneration 2014-04-29 Risk factors

    Neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and retinal degeneration have been studied extensively and varying molecular mechanisms have been proposed for onset of such diseases.

  17. Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2014-01-08 Biomarkers

    Presenilin 1 (PSEN1) encodes the catalytic subunit of γ-secretase, and PSEN1 mutations are the most common cause of early onset familial Alzheimer's disease (FAD).

  18. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica communications 2013-07-06 Genetics

    The UPR is activated in disease affected regions in PSP and the genetic evidence shows that this activation increases risk for PSP and is not a protective response.

  19. Deletion of Abca7 increases cerebral amyloid-β accumulation in the J20 mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013-03-01 Genetics

    ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons.

  20. Genetic insights in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Lancet. Neurology 2013-01-01 Genetics

    In the search for new genes in Alzheimer's disease, classic linkage-based and candidate-gene-based association studies have been supplanted by exome sequencing, genome-wide sequencing (for mendelian forms of Alzheimer's disease), and genome-wide association studies (for non-mendelian forms).

  21. Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Human molecular genetics 2012-11-28 Genetics

    Common diseases such as endometriosis (ED), Alzheimer's disease (AD) and multiple sclerosis (MS) account for a significant proportion of the health care burden in many countries.

  22. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Translational psychiatry 2012-07-03 Genetics

    Alzheimer's disease (AD) and bipolar disorder (BD) are progressive brain disorders.

  23. Discovery of sexual dimorphisms in metabolic and genetic biomarkers

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS genetics 2011-08-11 Genetics

    Metabolomic profiling and the integration of whole-genome genetic association data has proven to be a powerful tool to comprehensively explore gene regulatory networks and to investigate the effects of genetic variation at the molecular level.

  24. Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2011-01-21 Genetics

    Recent studies strongly indicate that aberrations in the control of gene expression might contribute to the initiation and progression of Alzheimer's disease (AD).

  25. Implication of the Immune System in Alzheimer's Disease: Evidence from Genome-Wide Pathway Analysis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Alzheimer s Disease 2010-06-13 Genetics

    The results of several genome-wide association studies (GWASs) in the field of Alzheimer's disease (AD) have recently been published.

From across this topic

10 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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