Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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The major known genetic risk for Alzheimer's disease (AD), apolipoprotein E-4 (APOE-4), is associated with lowered parietal, temporal, and posterior cingulate cerebral glucose metabolism in patients with a clinical diagnosis of AD.
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By multiple logistic regression, the APOE-epsilon 4 allele frequency was significantly higher in the patients positive for HSV1 in brain than in the HSV1-negative AD group, the HSV1-positive non-AD group, or the HSV1-negative non-AD group (52.8% vs 10.0%, 3.6%, and 6.3%, respectively).
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CAG trinucleotide expansion is the molecular basis of Huntington's disease worldwide and is a highly sensitive and specific marker for inheritance of the disease mutation.
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The existence of human hippocampal neurogenesis has long been disputed1-12 and its relevance in cognition remains unknown.
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Type 2 diabetes is an established risk factor for dementia.
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To better characterize the potential biological mechanisms underlying insulin resistance (IR) and dementia, we derive cross-population and population specific polygenic scores [PSs] for fasting insulin and IR-related partitioned PSs [pPSs].
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Augmenting traditional genome-wide association studies (GWAS) with advanced machine learning algorithms can allow the detection of novel signals in available cohorts.
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Associations between epigenetic AA and cognitive performance over-time varied by sex.
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Eighty-six rare missense or loss-of-function (LoF) variants completely segregated in 17.5% of families, but in 91 (22.1%) families Apolipoprotein E (APOE)-𝜀4 was the only variant segregating.
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50/100
As of 2023, it is estimated that 6.7 million individuals in the United States live with Alzheimer's disease (AD).
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The pleiotropic nature of the apolipoprotein E (APOE) gene is associated with complex diseases in different populations.
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50/100
Although psychotic symptoms have been described in association with rare presenilin ( PSEN ) gene mutations underlying early-onset Alzheimer disease (AD), no contemporary reviews on this topic exist.
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50/100
We identified 115 pathology-confirmed rpAD cases and 193 clinical rpAD cases, 80% and 69% were of non-Hispanic European ancestry.
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Five loci showed genome-wide significant association with CSF profiles, two were novel (rs145791381 [inflammation] and GRIN2D [synaptic functioning]) and three were previously described (APOE, TMEM106B, and CHI3L1).
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Previous genome-wide association studies have identified numerous genetic variants and revealed the genetic architecture of educational attainment, another marker of cognitive reserve.
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Affinity-based proteomics has enabled scalable quantification of thousands of protein targets in blood enhancing biomarker discovery, understanding of disease mechanisms, and genetic evaluation of drug targets in humans through protein quantitative trait loci (pQTLs).
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Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation.
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50/100
PS2V levels increased in AD postmortem brain but PS2V was also present at significant levels in FTD and LBD brains.
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There was no difference in age acceleration between dementia cases and controls.
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50/100
Genome wide association studies (GWAS) of human diseases have generally identified many loci associated with risk with relatively small effect sizes.
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50/100
Mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein (APP) are major genetic causes of early-onset Alzheimer's disease (EOAD).
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50/100
Familial Alzheimer's disease (FAD) is characterized by a positive family history of dementia and typically occurs at an early age with an autosomal dominant pattern of inheritance.
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Language impairment is common in prodromal stages of Alzheimer's disease (AD) and progresses over time.
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The TT genotype of rs688 in the LDLR gene was not found to be associated with elevated levels of total cholesterol or LDL-C.
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An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the hippocampus of a cohort of 41 late-onset AD (LOAD) patients and 23 controls, showing deregulation of 35 miRNAs.
From across this topic
9 of the 933 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- A decade in psychiatric GWAS research
- Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-β accumulation in App NL-G-F mice
- Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer's disease
- Associating genes and protein complexes with disease via network propagation
- Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience
- Parental Dementia History is Associated with Peripheral Immune Aging Rather than Generalized Biological and Brain Age Acceleration in Midlife
- The Genetics of Alzheimer's Disease in the Chinese Population
- Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases
- Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia