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151 studies tagged eye, dated 1986-08-01 to 2026-10-22. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Retinal biomarkers and dementia risk: A review of evidence across the 14 Lancet modifiable risk factors for dementia 2026-10-22
- Multimodal Retinal Imaging for the Detection of Early Alzheimer’s Disease: Combining Biochemical, Structural, and Vascular Biomarkers 2026-08-17
- Electroretinography as a Noninvasive Biomarker of Alzheimer’s Disease and Related Dementias in Older Adults: A Systematic Scoping Review 2026-07-30
Studies
151 studies carry this tag.
Date range
1986 to 2026
Top journals
- Journal of Alzheimer's disease : JAD 13
- Alzheimer's & dementia (Amsterdam, Netherlands) 7
- Progress in retinal and eye research 7
- Alzheimer's & dementia : the journal of the Alzheimer's Association 4
- Investigative ophthalmology & visual science 4
89 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Alzheimer's disease (AD) is associated with inner retina (nerve fiber and ganglion cell layers) thinning.
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The timely detection of neurodegenerative diseases is central to improving clinical care as well as enabling the development and deployment of disease-modifying therapies.
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Dementia is a term for loss of memory, language, problem-solving, and other thinking abilities, which significantly interferes with daily life.
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Alzheimer's disease (AD) is a leading cause of dementia, and the current diagnostic methods of AD, such as positron emission tomography imaging, have a high cost and poor accessibility.
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The retina has been increasingly investigated as a site of Alzheimer's disease (AD) manifestation for over a decade.
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The possible interconnection between the eye and central nervous system (CNS) has been a topic of discussion for several years just based on fact that the eye is properly considered an extension of the brain.
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Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by neuronal loss, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tau tangles.
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Retinal neurodegeneration and visual dysfunctions have been reported in a majority of Alzheimer's and Parkinson's patients, and, in light of the quest for novel biomarkers for these neurodegenerative proteinopathies, the retina has been receiving increasing attention as an organ for diagnosing, monitoring, and understanding disease.
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The vessel parameters [P vessel length density=0.005 and P vessel perfusion density=0.006) and average choroid thickness (P<0.001) in the macular area of the ATD group was less than the control group.
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Identifying biomarkers of Alzheimer's disease (AD) will accelerate the understanding of its pathophysiology, facilitate screening and risk stratification, and aid in developing new therapies.
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Saccadometry revealed slowed peak velocity compared to controls most evident vertically.
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Given the fact that different types of dementia can be diagnosed only postmortem or when the disease has progressed enough to cause irreversible damage to certain brain areas, there has been an increasing need for the development of sensitive and reliable methods that can detect early preclinical forms of dementia, before the symptoms have even appeared.
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Alzheimer's disease (AD) is one of the most common causes of dementia worldwide.
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Fourteen studies assessing OCT-A in preclinical Alzheimer's disease (AD), mild cognitive impairment, or AD were included.
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Optical Coherence Tomography Angiography (OCTA) is a non-invasive imaging technique that has been increasingly used to image the retinal vasculature at capillary level resolution.
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74/100
Topic Visual impairment (VI) and cognitive impairment (CIM) are prevalent age-related conditions that impose substantial burden on the society.
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59/100
A total of 124 eyes of 69 participants with PD (39 men [56.5%]; mean [SD] age, 71.7 [7.0] years) and 248 eyes of 137 control participants (77 men [56.2%]; mean [SD] age, 70.9 [6.7] years) were analyzed.
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Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts of information about the structure, function and molecular composition of retinal tissue in humans in vivo.
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Seventy-one studies were included for review, representing a total of 6757 patients (2350 AD, 793 MCI, 2902 healthy controls (HC), and 841 others with a range of other neurodegenerative diagnoses).
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Alzheimer's disease (AD) is a neurodegenerative disorder, the most common form of dementia.
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As visual impairment, cataract, and diabetic retinopathy are associated with an increased likelihood of developing dementia, early diagnosis may help identify those at risk of dementia.
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Hyperspectral data and retinal nerve fiber layer thickness data were used in a linear discriminant classification model to discriminate between AD patients and controls.
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The main advantages of optical retinal imaging may allow researchers to achieve deeper analysis of retinal ganglion cells (GC) in vivo using optical coherence tomography (OCT).
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Over 68,904 person-years of follow-up, 1,349 participants developed dementia.
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In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly.
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77/100
Thinning of retinal layers, measured using optical coherence tomography (OCT), is associated with some neurodegenerative disorders such as established Alzheimer's disease and multiple sclerosis.
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39/100
Spectral-domain optical coherence tomography (SD-OCT) is an accessible clinical tool for measuring structural changes to the retina, and increasingly as a biomarker for brain-predominant neurodegenerative diseases like Alzheimer's. Information about retinal function can also be extracted from OCT images, but is under-studied, with literature examples often employing challenging protocols or requiring specialized hardware.
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Retinal microcirculation shares similar features with cerebral small blood vessels.
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Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ) signaling are prominent features of the blood-brain barrier breakdown described in Alzheimer's disease (AD) that can predict cognitive decline yet have never been studied in the retina.
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These results show that different isoforms of Aβ can be detected in the human retina and moreover support the growing number of studies indicating that AD-related pathological changes occurring in the brain could be reflected in the retina.
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Diabetes mellitus, together with its complications, has been increasing in prevalence worldwide.
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Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (Aβ), may serve as surrogate markers of brain Aβ levels.
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The outer plexiform layer line had one of the lowest mean error ratios (2%), while RNFL had the highest (23%).
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OCT measurements did show significant decrease in temporal, nasal, inferiorR (R means examination of retina in two sections as superior and inferior instead of four quadrants) RNFL thickness and foveal, parafoveal, macular thickness of AD group compared to control group.
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It could be shown that Alzheimer type dementia, Parkinson's disease, multiple sclerosis. cerebral infarction and CADASIL are neuronal diseases with rarification of retinal vessels and atrophy of the retinal layers in the ocular fundus.
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Visual impairment is common in people living with dementia and regular ophthalmological exams may improve their quality of life.
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We found no disease effects on retinal vascular measures (all β's < |0.15|, all P > .2), adjusted for confounders.
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Compared to controls, returning FTD patients (143 vs. 130 μm, p = 0.005) and the tauopathy subgroup (143 vs. 128 μm, p = 0.03) had thinner outer retinas but similar inner layer thicknesses.
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Alzheimer's participants showed significantly reduced macular VD, PD, and GC-IPL thickness compared with MCI and controls.
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In terms of the retinal neuronal structure, multiple retinal neuronal layers are significantly thinner in Alzheimer's disease dementia, such as the parapapillary retinal nerve fiber layer (RNFL) and macular ganglion cell-inner plexiform layer (GC-IPL).
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In-vivo labeling of retinal amyloid-beta(Aβ) and tau has potential as non-invasive biomarker for Alzheimer's disease (AD).
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Optical coherence tomography (OCT) is a well-established technique for the clinical examination, diagnosis, severity staging and monitoring of ophthalmic disorders.
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59/100
Fifty-eight eyes from 30 participants (53% female; mean [SD] age, 74.5 [5.6] years; age range, 62-92 years) were included in the analysis.
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66/100
Topic OCT is a noninvasive tool to measure specific retinal layers in the eye.
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The ensuing upward shift in demographic distribution due to the increase in life expectancy has resulted in a rising prevalence of Alzheimer's disease (AD).
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39/100
OCTA has been applied in research to advance our understanding of the pathobiology of neurological disorders.
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Visual dysfunction has long been recognized as a manifestation of Alzheimer's disease (AD), particularly in the form of visuospatial impairment during all stages of disease.
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There was a significant increase in the total number of macular and peripheral hard drusen in older, compared to younger, normal eyes (p<0.05).
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The retina offers a unique "window" to study pathophysiological processes of dementia in the brain, as it is an extension of the central nervous system (CNS) and shares prominent similarities with the brain in terms of embryological origin, anatomical features and physiological properties.
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The geometric distribution and increased burden of retinal amyloid pathology in AD, together with the feasibility to noninvasively detect discrete retinal amyloid deposits in living patients, may lead to a practical approach for large-scale AD diagnosis and monitoring.
From across this tag
7 of the 151 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.
- Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease
- High occurrence rate of glaucoma among patients with Alzheimer's disease
- Optic nerve damage in Alzheimer's disease
- Retinal pathology in Alzheimer's disease. I. Ganglion cell loss in foveal/parafoveal retina
- Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies
- Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
- Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends