Home › Research › Topics › default-mode
default-mode
187 studies tagged default-mode, dated 1998-03-01 to 2026-10-28. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- From group-level neurophysiological biomarkers to individual-level phenotyping to identify mechanisms of neurodegenerative disease 2026-10-28
- Beyond reduced alpha power: a weaker temporal link between alpha and other brain rhythms in Alzheimer’s disease 2026-10-26
- Network Localization of Anxiety as an Early Manifestation of Alzheimer’s Disease-related Neurodegeneration 2026-10-26
Studies
187 studies carry this tag.
Date range
1998 to 2026
Top journals
- Frontiers in aging neuroscience 10
- bioRxiv 10
- Brain : a journal of neurology 9
- Human brain mapping 7
- Journal of Alzheimer's disease : JAD 7
88 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
-
Precision medicine approaches require physiological effects to be informative when translated to the individual.
-
At the group level, the resting alpha abnormality in AD comprises two partly nonredundant dimensions: reduced expression and a weaker temporal link between alpha and subsequent multi-rhythm activity.
-
Anxiety localizes to a brain circuit resembling the AD-related atrophy network, is consistent across the AD continuum and may extend beyond AD.
-
Dynamic functional network connectivity (dFNC) commonly identifies recurring connectivity states from resting-state fMRI, but states derived independently in each dataset lack guaranteed correspondence across studies and cannot be directly estimated in new participants.
-
The disorders fell into one of three categories based on the topographic relationship of the disease-specific and healthy networks.
-
For more than 150 years, since the idea that mental illness is rooted in the brain first emerged in the mid-1800s, psychiatry has searched for a reliable biological system to anchor its understanding of mental illness.
-
Our results converge on the conclusion that vtaVNS does not uniformly amplify cortical responses to external stimuli.
-
16/100
For more than 150 years, since the idea that mental illness is rooted in the brain first emerged in the mid-1800s, psychiatry has searched for a reliable biological system to anchor its understanding of mental illness.
-
We tested whether, across sexes, alignment with female-typical, rather than male-typical, patterns of neural functional connectivity (FC) would relate to a diagnosis (adolescent sample) or severity of symptoms (adult sample) associated with internalizing disorders, which tend to be more often diagnosed in females.
-
Of 204 normative reference models, 199 (97.5%) met the predefined diagnostic criteria; median held-out explained variance (EXPV) was 0.174.
-
This study reveals a myelin-mediated mechanism of rTMS action in AD, demonstrating the potential of promoting myelination as a novel therapeutic strategy for alleviating AD-related cognitive impairment.
-
Launched in 2010 by the National Institutes of Health, the Human Connectome Project (HCP) represents a foundational initiative in systems neuroscience, designed to map the structural and functional architecture of the human brain.
-
Our findings indicate that all methods captured AD disconnection patterns but exhibited variability in preserving connectivity profiles, which seemed non-random but rather systematically linked to clinical measures and predictive power for AD classification.
-
The theta/alpha ratio is a promising but specification-dependent marker of cognitive impairment, contingent particularly on ICA and spectral power quantification.
-
Amyloid-β and tau, pathological hallmarks of AD, silently accumulate years before clinical symptoms’ onset and are associated with neuronal dysfunction and cognitive impairment.
-
Only the reliability half of that contrast is individually significant.
-
The medial temporal lobe (MTL) is crucial for episodic memory.
-
Understanding how a stable structural connectome supports flexible cognition, especially in aging, is a fundamental question in neuroscience.
-
Alzheimer’s disease disrupts large-scale brain networks before cognitive symptoms emerge, yet the mechanisms underlying this progression remain unclear.
-
We found opposite effects of age on FMAR at both short and long time scales, respectively (ßAge=0.014, 95% C.I. [0.009,0.019] and ßAge=-0.015, 95% C.I. [-0.026,-0.005]), as well as differences between women and men at long time scales (ßSexMen=+0.028, 95% C.I. [0.012,0.044]).
-
52/100
Group comparisons revealed significantly decreased within-network connectivity in salience-ventral attention, cognitive control, and default mode network in participants with postoperative delirium (n=31) compared with non-delirious participants (n=89; non-parametric permutation test, 1000 iterations, P<0.05).
-
43/100
The default mode network (DMN) is intricately linked with processes such as self-referential thinking, episodic memory recall, goal-directed cognition, self-projection, and theory of mind.
-
Rs-fMRI analysis revealed significant associations between FC and MedDietScore.
-
71/100
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration.
-
43/100
Resting-state functional connectivity (FC) MRI is sensitive to brain changes in Alzheimer's disease in preclinical stages, however studies in persons with subjective cognitive decline (SCD) have reported conflicting findings, and no study is available at 7T MRI.
-
79/100
EA intervention could increase the MoCA score and improve the neutral and consistency response of the STROOP test in VCIND patients (P < 0.05). fMRI functional connectivity analysis showed that, after EA, the default mode network (DMN) function of the posterior cingulate gyrus, left middle frontal gyrus, left anterior cingulate gyrus, left and right superior temporal gyrus, right insula, left precentral gyrus and other brain regions were significantly higher than that in the control group.
-
Altered functional connectivity precedes structural brain changes and symptoms in dementia.
-
We found that anosognosia was associated with (i) weak functional connectivity within the DMN, in posterior and middle cingulate cortex particularly, (ii) strong functional connectivity within the SN in ACC, and between the SN and basal ganglia, and (iii) a heterogenous effect concerning the functional connectivity of the FPN, with a weak connectivity between the FPN and PCC, and a strong connectivity between the FPN and ACC.
-
Multimodal biomarkers may identify former contact sports athletes with repeated concussions and at risk for dementia.
-
On DTI, PCA showed degeneration in occipito-parietal white matter, posterior thalamic radiations, splenium of the corpus collosum and sagittal stratum compared to DLB and CU, with greater degeneration in the temporal white matter and the fornix compared to CU.
-
45/100
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease (AD), first accumulates cortically in the default mode network (DMN), years before AD diagnosis.
-
The disruption of functional connectivity is one of the early events that occurs in the brains of Alzheimer's disease (AD) patients.
-
Alzheimer's disease (AD), affecting nearly 6.5 million people, is the fifth leading cause of death in individuals 65 years or older in the USA.
-
Cognitive Reserve (CR) refers to the preservation of cognitive function in the face of age- or disease-related neuroanatomical decline.
-
The FC between the retrosplenial (RSC) and parahippocampal cortices (PHC) was the earliest affected FC, while a manifest SC change in the ventral cingulum and fornix was observed in the later ADD stage.
-
Reduced within-network connectivity was observed in the language network in both phenotypes, with stronger evidence of reductions in logopenic progressive aphasia compared to controls.
-
Recent advancements in computational approaches and neuroimaging techniques have refined our understanding of the precuneus.
-
No between-group differences in grey matter volumes were detected.
-
Behavioral variant of frontotemporal dementia (bvFTD) is common among young-onset dementia patients.
-
Numerous studies have shown abnormal brain functional connectivity in individuals with Alzheimer's disease (AD) or amnestic mild cognitive impairment (aMCI).
-
Individuals with AD were clustered into 4 subtypes reproducibly, which included those with 1) diffuse and mild functional connectivity disruption (subtype 1), 2) predominantly decreased connectivity in the default mode network accompanied by an increase in the prefrontal circuit (subtype 2), 3) predominantly decreased connectivity in the anterior cingulate cortex accompanied by an increase in prefrontal cortex connectivity (subtype 3), and 4) predominantly decreased connectivity in the basal ganglia accompanied by an increase in prefrontal cortex connectivity (subtype 4).
-
We explored the resting state functional connectivity correlates of apathy assessed as a multidimensional construct, using behavioral metrics, in behavioral variant frontotemporal dementia (bvFTD).
-
48/100
When comparing SCD (N = 40) with NC (N = 45), mdALFFmean decreased at right inferior parietal lobule (IPL) of the frontoparietal network (FPN).
-
In the precuneus, we observed an inverted U-shaped pattern of novelty-related activity across groups, with higher activity in SCD and MCI compared with HC, but not in patients with AD who showed relatively lower activity than MCI.
-
Associations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer's cognitive composite-5 score, and BMI; and (iv) a "DMN-negatively connected" state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure.
-
Cognitive reserve (CR) is the ability to preserve cognitive functions in the presence of brain pathology.
-
41/100
"Brain-predicted age" quantifies apparent brain age compared to normative neuroimaging trajectories.
-
Subjective cognitive decline (SCD), as expressed by older adults, is associated with negative affect, which, in turn, is a likely risk factor for Alzheimer's Disease (AD).
-
Alzheimer's disease-related atrophy in the posterior cingulate cortex, a key node of the default mode network, is present in the early stages of disease progression across clinical phenotypic variants of the disease.
-
Discrimination of disease-related interactions of the core subsystem and FPN was found in AD-spectrum patients, which was the neural circuit fundamental to plasma NFL disrupting cognitive integrity.
From across this tag
5 of the 187 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 5. The same 5 appear here every time.
- The Role of Resting-State Network Functional Connectivity in Cognitive Aging
- The role of the posterior cingulate cortex in cognition and disease
- Aberrant functional organization within and between resting-state networks in AD
- Alzheimer's disease disrupts alpha and beta-band resting-state oscillatory network connectivity
- Functional Brain Connectivity Patterns Associated with Visual Hallucinations in Dementia with Lewy Bodies