Home › Research › Topics › default-mode
default-mode
188 studies tagged default-mode, dated 1998-03-01 to 2026-10-28. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- From group-level neurophysiological biomarkers to individual-level phenotyping to identify mechanisms of neurodegenerative disease 2026-10-28
- Beyond reduced alpha power: a weaker temporal link between alpha and other brain rhythms in Alzheimer’s disease 2026-10-26
- Network Localization of Anxiety as an Early Manifestation of Alzheimer’s Disease-related Neurodegeneration 2026-10-26
Studies
188 studies carry this tag.
Date range
1998 to 2026
Top journals
- Frontiers in aging neuroscience 10
- bioRxiv 10
- Brain : a journal of neurology 9
- Human brain mapping 7
- Journal of Alzheimer's disease : JAD 7
89 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
-
41/100
We found that the dementia groups showed worse PM performance and altered FC within the DMN as compared to the normal aging individuals.
-
71/100
We demonstrated that higher amyloid burden as measured by both CSF amyloid beta 42/40 ratio and non-displaceable binding potential in the posterior cingulate cortex was associated with lower functional connectivity in the default mode network.
-
Both DELPHI analysis of network function and DTI analysis detected a significant decrease in connectivity, excitability, and WM integrity in the SCD group compared to healthy control (HC) subjects; a significant decrease was also noted for aMCI and Dementia groups compared to HC.
-
52/100
Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer's disease, but the functional brain mechanisms that support cognitive resilience remain elusive.
-
41/100
The past decade marked the beginning of the use of resting-state functional connectivity (RSFC) imaging in bilingualism studies.
-
Resting-state fMRI (rs-fMRI) detects functional connectivity (FC) abnormalities that occur in the brains of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI).
-
Seed-based analyses reported decreased connectivity of the lateral geniculate nucleus, the superior parietal lobule and the putamen with the medial frontal gyrus in DLB patients with VH.
-
The mechanisms through which tau and amyloid-beta (Aβ) accumulate in the brain of Alzheimer's disease patients may differ but both are related to neuronal networks.
-
We found no significant differences between the groups in age, sex, education, or cognitive level, but bilinguals showed higher FC than monolinguals between the posterior part of the superior temporal gyrus and the precuneus, positively correlated with Mini-Mental State Examination scores, and higher fALFF in the thalamus bilaterally.
-
Alzheimer's disease (AD) is the most common type of dementia, and depression is a risk factor for developing AD.
-
Studies of resting-state functional connectivity MRI in Alzheimer's disease suggest that disease stage plays a role in functional changes of the default mode network.
-
Non-linear relations of brain amyloid beta (Aβ) with task- based functional connectivity (tbFC) measured with functional magnetic resonance imaging (fMRI) have been reported in late middle age.
-
Subcortical vascular mild cognitive impairment (svMCI) is a common prodromal stage of vascular dementia.
-
52/100
Compared to APOE ε4 non-carriers, APOE ε4 carriers had lower rsFC in temporal DMN, but only in non-Hispanic Whites.
-
Aging is associated with disruptions in the resting-state functional architecture of the brain.
-
54/100
There is both clinical and neuroanatomical variability at the single-subject level in Alzheimer's disease, complicating our understanding of brain-behaviour relationships and making it challenging to develop neuroimaging biomarkers to track disease severity, progression, and response to treatment.
-
Community-dwelling African American elders are twice as likely to develop mild cognitive impairment (MCI) or Alzheimer's disease and related dementias than older white Americans and therefore represent a significant at-risk group in need of early monitoring.
-
We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance, tau, and amyloid levels.
-
55/100
In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
-
Our results showed that compared to healthy older adults, aMCI patients showed lower anti-correlation between the cerebellar DMN and several cerebral DMN regions.
-
Studies of brain network connectivity improved understanding on brain changes and adaptation in response to different pathologies.
-
Mild cognitive impairment (MCI) often precedes Alzheimer's Dementia (AD), and in a high proportion of individuals affected by MCI, there are already neuropathological processes ongoing that become more evident when patients progress to AD.
-
Mild cognitive impairment is defined as greater cognitive decline than expected for a person at a particular age and is sometimes considered a stage between healthy aging and Alzheimer's disease or other dementia syndromes.
-
Older adults with depression showed increased ReHo in the bilateral dorsal anterior cingulate cortex (dACC) and the right middle temporal gyrus, with no significant findings for network homogeneity.
-
The default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture.
-
48/100
In Alzheimer's disease, tau pathology spreads hierarchically from the inferior temporal lobe throughout the cortex, ensuing cognitive decline and dementia.
-
Accumulating evidence suggests that memory is impaired in posterior cortical atrophy (PCA), alongside the early and defining visual disorder.
-
46/100
Alzheimer's disease is considered a disconnection syndrome, motivating the use of brain network measures to detect changes in whole-brain resting state functional connectivity (FC).
-
We found that education level was positively associated with a wide range of complex cognitive domains including general mental status, episodic memory, language, attention, executive function and visuospatial processing, and it showed significantly negative correlations with FC of multiple areas in the Default Mode Network (DMN) and Left Frontal-parietal Network (LFP) which are related to complex cognition.
-
Studies generally indicate a progressive impairment in DMN connectivity during the course of AD.
-
According to the network model of neurodegeneration, the spread of pathogenic proteins occurs selectively along connected brain regions.
-
Neuroscience is developing rapidly by providing a variety of modern tools for analyzing the functional interactions of the brain and detection of pathological deviations due to neurodegeneration.
-
75/100
Seventeen studies with cognitively impaired Parkinson's disease patients were included consisting of 222 Parkinson's disease patients with mild cognitive impairment, 68 patients with Parkinson's disease dementia, 289 cognitively unimpaired Parkinson's disease patients and 353 healthy controls.
-
Patients with PCA showed disproportionate deficits in the visuospatial domain; they also showed preserved social sensitivity and endorsed more depressive symptoms than HCs.
-
One hundred sixteen participants (Aβ- cognitively normal [CN], n = 35; Aβ- aMCI, n = 42; Aβ+ aMCI, n = 39) were included.
-
Studies have demonstrated that the clinical manifestations of Alzheimer's disease (AD) are associated with abnormal connections in either functional connectivity networks (FCNs) or structural connectivity networks (SCNs).
-
The default mode network (DMN), one of so-called resting-state networks, has been associated with cognitive processes that are directed toward the self, such as introspection and autobiographic memory.
-
Alzheimer's disease (AD) is the most common form of dementia, with no means of cure or prevention.
-
Brain functional imaging data, especially functional magnetic resonance imaging (fMRI) data, have been employed to reflect functional integration of the brain.
-
Locus of control (LOC) is an important personality trait.
-
Social withdrawal is one of the first and common signs of early social dysfunction in a number of important neuropsychiatric disorders, likely because of the enormous amount and complexity of brain processes required to initiate and maintain social relationships (Adolphs, 2009).
-
Trans-diagnostic, domain- or symptom-focused approaches have been heralded as advancing psychiatric research, but relatively few clinical research programmes have been undertaken to leverage their potential.
-
The cingulum bundle is a prominent white matter tract that interconnects frontal, parietal, and medial temporal sites, while also linking subcortical nuclei to the cingulate gyrus.
-
While the DLB patients scored well and did not differ from the control and AD groups in terms of functional activity and connectivity during the task conditions, they showed decreased functional connectivity in visuoperceptual regions during the resting state condition, along with a temporal impairment of the default-mode network activity.
-
In addition to an overview of the results, we briefly outline the methods applied to the concept of resting-state functional connectivity.
-
Alzheimer's disease is increasingly considered a large-scale network disconnection syndrome, associated with progressive aggregation of pathological proteins, cortical atrophy, and functional disconnections between brain regions.
-
Second, to investigate if regions of high tau burden are associated with functional connectivity networks, we extracted the region with the maximum z-value in each of the generated tau pathology networks and used them as seeds in a subsequent resting-state functional MRI analysis, conducted in a group of healthy adults (n = 26) who were part of the 1000 Functional Connectomes Project.
-
Lateralization of default mode network (DMN) functioning has been shown to change with age.
-
Dementia with Lewy bodies (DLB) is a common form of dementia and is characterized by cognitive fluctuations, visual hallucinations, and Parkinsonism.
-
Neurodegenerative diseases target specific large-scale neuronal networks, leading to distinct behavioral and cognitive dysfunctions.
From across this tag
8 of the 188 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Network-level functional connectivity is associated with longitudinal tau accumulation and amyloid-dependent cognitive decline in preclinical Alzheimer’s disease
- Mesoscale medial temporal lobe connectivity patterns relate to tau pathology and memory in older adults
- The functional role of the precuneus
- The precuneus and consciousness
- Abnormal network connectivity in frontotemporal dementia: evidence for prefrontal isolation
- Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: an fMRI study
- Preclinical Brain Network Abnormalities in Patients with Subjective Cognitive Decline
- Functional neural network analysis in frontotemporal dementia and Alzheimer's disease using EEG and graph theory