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The Role of Resting-State Network Functional Connectivity in Cognitive Aging
Hanna K Hausman, Andrew O'Shea, Jessica N Kraft, Emanuel M Boutzoukas, Nicole D Evangelista, Emily J Van Etten, Pradyumna K Bharadwaj, Samantha G Smith et al.. Frontiers in aging neuroscience, 2020-06-12
Topic: Brain imaging, connectivity and assessment
Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer's disease. However, due to mixed findings, it is unclear if changes in resting-state network functional connectivity are linked to cognitive decline in healthy older adults. In the present study, we evaluated the influence of intra-network coherence for four higher-order cognitive resting-state networks on a sensitive measure of cognitive aging (i.e., NIH Toolbox Fluid Cognition Battery) in 154 healthy older adults with a mean age of 71 and education ranging between 12 years and 21 years (mean = 16). Only coherence within the cingulo-opercular network (CON) was significantly related to Fluid Cognition Composite scores, explaining more variance in scores than age and education. Furthermore, we mapped CON connectivity onto fluid cognitive subdomains that typically decline in advanced age. Greater CON connectivity was associated with better performance on episodic memory, attention, and executive function tasks. Overall, the present study provides evidence to propose CON coherence as a potential novel neural marker for nonpathological cognitive aging.
Key findings
- Aging is associated with disruptions in the resting-state functional architecture of the brain.
- Only coherence within the cingulo-opercular network (CON) was significantly related to Fluid Cognition Composite scores, explaining more variance in scores than age and education.
- Greater CON connectivity was associated with better performance on episodic memory, attention, and executive function tasks.
- Overall, the present study provides evidence to propose CON coherence as a potential novel neural marker for nonpathological cognitive aging.
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Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 22 of the 56 points we could judge it on, which is 39 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32595490) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 22 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 22 of the 56 points we could judge it on is 39 out of 100. |
| Total | 39 / 100 | — |
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Hausman, H. K., O'Shea, A., Kraft, J. N., Boutzoukas, E. M., Evangelista, N. D., Van Etten, E. J., et al. (2020). The Role of Resting-State Network Functional Connectivity in Cognitive Aging. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2020.00177
Vancouver
Hausman HK, O'Shea A, Kraft JN, Boutzoukas EM, Evangelista ND, Van Etten EJ, et al. The Role of Resting-State Network Functional Connectivity in Cognitive Aging. Frontiers in aging neuroscience. 2020. doi:10.3389/fnagi.2020.00177. PMID: 32595490.
BibTeX
@article{hausman2020-32595490,
author = {Hausman, Hanna K and O'Shea, Andrew and Kraft, Jessica N and Boutzoukas, Emanuel M and Evangelista, Nicole D and Van Etten, Emily J and Bharadwaj, Pradyumna K and Smith, Samantha G and others},
title = {{The Role of Resting-State Network Functional Connectivity in Cognitive Aging}},
journal = {Frontiers in aging neuroscience},
year = {2020},
doi = {10.3389/fnagi.2020.00177},
pmid = {32595490},
url = {https://doi.org/10.3389/fnagi.2020.00177}
}
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