Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Hearing Loss and Cognition: What We Know and Where We Need to Go

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in aging neuroscience 2022-02-28 Risk factors

    Although a causal association remains to be determined, epidemiologic evidence suggests an association between hearing loss and increased risk of dementia.

  2. Mitigating site effects in covariance for machine learning in neuroimaging data

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Human brain mapping 2021-12-14 Digital health tools

    To acquire larger samples for answering complex questions in neuroscience, researchers have increasingly turned to multi-site neuroimaging studies.

  3. Bidirectional Mapping of Brain MRI and PET With 3D Reversible GAN for the Diagnosis of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in neuroscience 2021-04-09 Digital health tools

    Combining multi-modality data for brain disease diagnosis such as Alzheimer's disease (AD) commonly leads to improved performance than those using a single modality.

  4. New insights into atypical Alzheimer's disease in the era of biomarkers

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Lancet. Neurology 2021-03-01 Risk genes beyond APOE

    Most patients with Alzheimer's disease present with amnestic problems; however, a substantial proportion, over-represented in young-onset cases, have atypical phenotypes including predominant visual, language, executive, behavioural, or motor dysfunction.

  5. Multimodal deep learning models for early detection of Alzheimer's disease stage

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Scientific reports 2021-02-05 Digital health tools

    Most current Alzheimer's disease (AD) and mild cognitive disorders (MCI) studies use single data modality to make predictions such as AD stages.

  6. Cognitive and behavioural flexibility: neural mechanisms and clinical considerations

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nature reviews. Neuroscience 2021-02-03 Prevention trials

    Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and behaviours in response to changing environmental demands.

  7. Validity of the MemTrax Memory Test Compared to the Montreal Cognitive Assessment in the Detection of Mild Cognitive Impairment and Dementia due to Alzheimer's Disease in a Chinese Cohort

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2021-01-01 Cognitive tests and assessment

    MemTrax can effectively detect both clinically diagnosed MCI and AD with better accuracy as compared to the MoCA based on AUCs in a Chinese cohort.

  8. Perspective on the "African American participation in Alzheimer disease research: Effective strategies" workshop, 2018

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-08-17 Disparities

    The Washington University School of Medicine Knight Alzheimer Disease Research Center's "African American Participation in Alzheimer Disease Research: Effective Strategies" Workshop convened to address a major limitation of the ongoing scientific progress regarding Alzheimer's disease and related dementias (ADRD): participants in most ADRD research programs overwhelmingly have been limited to non-Hispanic white persons, thus precluding knowledge as to how ADRD may be represented in non-white individuals.

  9. Sleep characteristics and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: The CABLE study

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-07-13 Tau biomarkers

    Greater daytime sleepiness was associated with higher CSF indicators of amyloid deposition in female patients.

  10. Commentary: Composite cognitive and functional measures for early stage Alzheimer's disease trials

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2020-05-15 Cognitive tests and assessment

    In this commentary I consider the issues raised in Schneider and Goldberg's review of composite cognitive and functional measures.

  11. The parahippocampal gyrus-orbitofrontal cortex (PHG-OFC) circuit in humans is homologous to the postrhinal cortex (POR)-ventral lateral orbitofrontal cortex (vlOFC) circuit in rodents.

  12. Effective differentiation of mild cognitive impairment by functional brain graph analysis and computerized testing

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. PloS one 2020-03-16 Cognitive tests and assessment

    Community-dwelling African American elders are twice as likely to develop mild cognitive impairment (MCI) or Alzheimer's disease and related dementias than older white Americans and therefore represent a significant at-risk group in need of early monitoring.

  13. Neuropathological Findings of Dementia Associated With Subjective Hearing Loss

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2019-10 Risk factors

    Two-hundred and seventy-three subjects were included, 189 normal hearing and 84 subjective hearing loss subjects.

  14. Early-Stage Identification and Pathological Development of Alzheimer's Disease Using Multimodal MRI

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2019 Brain scans and imaging

    Alzheimer's disease (AD) is one of the most common progressive and irreversible neurodegenerative diseases.

  15. Functional Re-organization of Cortical Networks of Senior Citizens After a 24-Week Traditional Dance Program

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in aging neuroscience 2018-12-21 Cognitive tests and assessment

    Neuroscience is developing rapidly by providing a variety of modern tools for analyzing the functional interactions of the brain and detection of pathological deviations due to neurodegeneration.

  16. High-resolution magnetic resonance imaging reveals nuclei of the human amygdala: manual segmentation to automatic atlas

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. NeuroImage 2017-05-04 Brain scans and imaging

    The amygdala is composed of multiple nuclei with unique functions and connections in the limbic system and to the rest of the brain.

  17. Google Calendar Enhances Prospective Memory in Alzheimer's Disease: A Case Report

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Cognitive tests and assessment

    We investigated whether an external memory aid (i.e., Google Calendar) would alleviate prospective memory compromise in a patient with mild Alzheimer's disease.

  18. Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2016-10-01 Cognitive tests and assessment

    It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer's disease(AD).

  19. The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The journal of prevention of Alzheimer's disease 2016-03-01 Cognitive tests and assessment

    Excellent reliability was observed among the 6 C3-PAD alternate versions (Cronbach alpha coefficient=0.93).

  20. Automatic speech analysis for the assessment of patients with predementia and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2015-03-29 Digital health tools

    Automatic speech analyses could be an additional objective assessment tool for elderly with cognitive decline.

  21. Gaussian process classification of Alzheimer's disease and mild cognitive impairment from resting-state fMRI

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. NeuroImage 2015-02-28 Digital health tools

    Multivariate pattern analysis and statistical machine learning techniques are attracting increasing interest from the neuroimaging community.

  22. Multimodal analysis of functional and structural disconnection in Alzheimer's disease using multiple kernel SVM

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Human brain mapping 2015-02-09 Digital health tools

    Alzheimer's disease (AD) patients exhibit alterations in the functional connectivity between spatially segregated brain regions which may be related to both local gray matter (GM) atrophy as well as a decline in the fiber integrity of the underlying white matter tracts.

  23. A web-based non-intrusive ambient system to measure and classify activities of daily living

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of medical Internet research 2014-07-21 Cognitive tests and assessment

    To provide effective care, they need to know how patients cope with ADL, in particular, the estimation of risks associated with the cognitive decline.

  24. Validity of a brief computerized cognitive screening test in dementia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of geriatric psychiatry and neurology 2012-06-01 Cognitive tests and assessment

    CogState and standard neuropsychological task scores were significantly lower for dementia participants than that of the nondementia groups (P < .05), with a single CogState test distinguishing control from MCI participants, but minimal differentiation existing between dementias using the CogState.

  25. Association of lifetime cognitive engagement and low β-amyloid deposition

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Archives of neurology 2012-05-01 Brain scans and imaging

    Individuals with greater early- and middle-life cognitive activity had lower [(11)C]PiB uptake.

From across this topic

10 of the 1,533 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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