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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Structural Basis for Chaperone-Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Angewandte Chemie (International ed. in English) 2022-02-18 Prevention trials

    The multi-site ubiquitination of Tau protein found in Alzheimer's disease filaments hints at the failed attempt of neurons to remove early toxic species.

  2. Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European journal of nuclear medicine and molecular imaging 2022-02-07 Drug development

    PBB5 showed specific binding to recombinant K18 tau fibrils by fluorescence assay, to post-mortem Alzheimer's disease brain tissue homogenate by competitive binding against [11C]PBB3 and to tau deposits (AT-8 positive) in post-mortem corticobasal degeneration and progressive supranuclear palsy brains.

  3. TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell calcium 2022-02-05 Disease mechanisms

    Neurodegenerative diseases (ND) pose a serious health burden to society and healthcare systems alike, with increasing incidence rates especially within aging populations.

  4. The interplay between oxidative stress and autophagy: focus on the development of neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Behavioral and brain functions : BBF 2022-01-29 Disease mechanisms

    Regarding the epidemiological studies, neurological dysfunctions caused by cerebral ischemia or neurodegenerative diseases (NDDs) have been considered a pointed matter.

  5. Protein degradation-associated mechanisms that are affected in Alzheimer´s disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular and cellular biochemistry 2022-01-27 Disease mechanisms

    Alzheimer's disease (AD) is the most common type of dementia associated with age-related neurodegeneration.

  6. A hybrid approach unveils drug repurposing candidates targeting an Alzheimer pathophysiology mechanism

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Patterns (New York, N.Y.) 2022-01-26 Drug development

    The high number of failed pre-clinical and clinical studies for compounds targeting Alzheimer disease (AD) has demonstrated that there is a need to reassess existing strategies.

  7. Magnetic Resonance Imaging in Tauopathy Animal Models

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2022-01-25 Brain scans and imaging

    The microtubule-associated protein tau plays an important role in tauopathic diseases such as Alzheimer's disease and primary tauopathies such as progressive supranuclear palsy and corticobasal degeneration.

  8. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta materia medica 2022-01-21 Disease mechanisms

    Neurodegenerative diseases (NDs) are characteristic with progression of neuron degeneration, resulting in dysfunction of cognition and mobility.

  9. CaMKIIβ knockdown decreases store-operated calcium entry in hippocampal dendritic spines

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. IBRO neuroscience reports 2022-01-10 Disease mechanisms

    Calcium/calmodulin-dependent protein kinase II (CaMKII) and neuronal store-operated calcium entry (nSOCE) have been implicated in the development of Alzheimer's disease (AD). nSOCE is involved in regulation of dendritic spine shape, particularly in stability of mushroom spines that play role in formation of strong synapses.

  10. Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2022 Biomarkers

    We found that LFS enhanced p-Tau181 and p-Tau217 in an age-dependent manner in the hippocampus of live rats.

  11. Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neural regeneration research 2022-01 Risk genes beyond APOE

    The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form.

  12. Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2022 Brain scans and imaging

    3xTg mice exhibited nuanced deficits in RGC electrical signaling, axonal transport, and synaptic integrity that exceeded normal age-related decrements in RGC function in age- and sex-matched healthy control mice.

  13. Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Annals of medicine 2021-12 Risk genes beyond APOE

    Alzheimer's disease (AD) is the most conspicuous chronic neurodegenerative syndrome, which has become a significant challenge for the global healthcare system.

  14. Structure-activity relationship around PI-2620 highlights the importance of the nitrogen atom position in the tricyclic core

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Bioorganic & medicinal chemistry 2021-11-20 Brain scans and imaging

    Tau aggregates represent a critical pathology in Alzheimer's disease (AD) and other forms of dementia.

  15. α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell & bioscience 2021-11-19 Brain tissue and pathology

    Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain.

  16. The Interplay of the Unfolded Protein Response in Neurodegenerative Diseases: A Therapeutic Role of Curcumin

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2021-11-19 Disease mechanisms

    Abnormal accumulation of misfolded proteins in the endoplasmic reticulum and their aggregation causes inflammation and endoplasmic reticulum stress.

  17. The role of pathological tau in synaptic dysfunction in Alzheimer's diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational neurodegeneration 2021-11-10 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline, accompanied by amyloid-β (Aβ) overload and hyperphosphorylated tau accumulation in the brain.

  18. Noncognitive species-typical and home-cage behavioral alterations in conditional presenilin 1/presenilin 2 double knockout mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Behavioural brain research 2021-11-07 Risk genes beyond APOE

    Impairments in activities of daily living (ADL) are common clinical symptoms of human Alzheimer's disease (AD).

  19. Truncating tau reveals different pathophysiological actions of oligomers in single neurons

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Communications biology 2021-11-04 Drug development

    Tau protein is involved in maintaining neuronal structure.

  20. Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational psychiatry 2021-11-03 Risk genes beyond APOE

    Presenilin (PS) with a genetic mutation generates abundant β-amyloid protein (Aβ) 43.

  21. Protein clearance strategies for disease intervention

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2021-10-23 Disease mechanisms

    Protein homeostasis, or proteostasis, is essential for cell function and viability.

  22. Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cell and developmental biology 2021-10-04 Disease mechanisms

    Memory impairments are associated with many brain disorders such as autism, Alzheimer's disease, and depression.

  23. Ocular Neurodegenerative Diseases: Interconnection between Retina and Cortical Areas

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2021-09-12 Brain scans and imaging

    The possible interconnection between the eye and central nervous system (CNS) has been a topic of discussion for several years just based on fact that the eye is properly considered an extension of the brain.

  24. Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2021-09-09 Brain tissue and pathology

    Immunohistochemical analysis of M20/L85 mice revealed that pre-existing Aβ plaques exacerbate the spread and deposition of induced α-synuclein pathology.

  25. Synaptic tau: A pathological or physiological phenomenon?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta neuropathologica communications 2021-09-09 Disease mechanisms

    In this review, we discuss the synaptic aspects of Tau pathology occurring during Alzheimer's disease (AD) and how this may relate to memory impairment, a major hallmark of AD.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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