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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. The potential of microelectrode arrays and microelectronics for biomedical research and diagnostics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Analytical and bioanalytical chemistry 2010-07-31 Risk factors

    Planar microelectrode arrays (MEAs) are devices that can be used in biomedical and basic in vitro research to provide extracellular electrophysiological information about biological systems at high spatial and temporal resolution.

  2. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2010-07-26 Disease mechanisms

    Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of misfolded proteins, has been implicated in multiple neurodegenerative diseases.

  3. Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2010-07-01 Treatments

    Disruption of axonal transport is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD).

  4. Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. NeuroImage 2010-06-13 Brain scans and imaging

    Noninvasive monitoring of β-amyloid (Aβ) plaques, the neuropathological hallmarks of Alzheimer's disease (AD), is critical for AD diagnosis and prognosis.

  5. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell 2010-06-10 Risk genes beyond APOE

    Macroautophagy is a lysosomal degradative pathway essential for neuron survival.

  6. Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2010-05-31 Disease mechanisms

    Circadian disturbances, including a fragmented sleep-wake pattern and sundowning, are commonly reported early in the progression of Alzheimer's disease (AD).

  7. Alzheimer's disease: strategies for disease modification

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Drug discovery 2010-05-01 Treatments

    Alzheimer's disease is the largest unmet medical need in neurology.

  8. Molecular mechanisms of neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2010-04-22 Disease mechanisms

    Alzheimer's disease (AD) is characterized by cognitive impairment, progressive neurodegeneration and formation of amyloid-beta (Abeta)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau.

  9. EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2010-04-12 Brain tissue and pathology

    Protein misfolding and formation of beta-sheet-rich amyloid fibrils or aggregates is related to cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's disease.

  10. Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature nanotechnology 2010-04-11 Brain scans and imaging

    The aggregation of proteins is central to many aspects of daily life, including food processing, blood coagulation, eye cataract formation disease and prion-related neurodegenerative infections.

  11. Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2010-03-22 Down syndrome and Alzheimer's

    Full-length amyloid beta peptides (Abeta(1-40/42)) form neuritic amyloid plaques in Alzheimer's disease (AD) patients and are implicated in AD pathology.

  12. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2010-02-23 Disease mechanisms

    Accumulation of amyloid-beta (Abeta) and Tau is an invariant feature of Alzheimer disease (AD).

  13. Amyloid oligomers: formation and toxicity of Abeta oligomers

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The FEBS journal 2010-02-09 Disease mechanisms

    Alzheimer's disease (AD) is an age-related, progressive degenerative disorder that is characterized by synapse and neuron loss in the brain and the accumulation of protein-containing deposits (referred to as 'senile plaques') and neurofibrillary tangles.

  14. Acetylcholinesterase: from 3D structure to function

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Chemico-biological interactions 2010-02-04 Disease mechanisms

    By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses.

  15. Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2010-02-01 Risk factors

    Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density.

  16. Assessing the Stability of Alzheimer’s Amyloid Protofibrils Using Molecular Dynamics

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of Physical Chemistry B 2010-01-07 Brain tissue and pathology

    Amyloid fibrils represent a stable form of many misfolded proteins associated with numerous diseases.

  17. Exercise plays a preventive role against Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2010-01-01 Prevention trials

    Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population.

  18. Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2009-12-28 Down syndrome and Alzheimer's

    An additional copy of the beta-amyloid precursor protein (APP) gene causes early-onset Alzheimer's disease (AD) in trisomy 21 (DS).

  19. Neuropathology of non-motor features of Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Parkinsonism & related disorders 2009-12-01 Brain scans and imaging

    Non-motor manifestations of Parkinson disease (PD) are common and some may actually antedate motor dysfunction.

  20. Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2009-11-06 Genetics

    Alzheimer's disease (AD) is characterized by amyloid-beta (Abeta)-containing plaques, neurofibrillary tangles, and neuron and synapse loss.

  21. Synaptic depression and aberrant excitatory network activity in Alzheimer's disease: two faces of the same coin?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuromolecular medicine 2009-10-17 Digital health tools

    Neurodegenerative diseases, including Alzheimer's disease (AD), target specific and functionally connected neuronal networks, raising the possibility that neurodegeneration may spread through abnormal patterns of neural network activity.

  22. Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2009-10-16 Drug development

    The hypothesis that amyloid-beta (Abeta) peptides are the primary cause of Alzheimer's disease (AD) remains the best supported theory of AD pathogenesis.

  23. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Drug discovery 2009-10-01 Clinical trials

    Neuronal inclusions comprised of the microtubule-associated protein tau are found in numerous neurodegenerative diseases, commonly known as tauopathies.

  24. Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Drug discovery 2009-09-01 Risk factors

    Nicotinic receptors - a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine - are among the most well understood allosteric membrane proteins from a structural and functional perspective.

  25. Function and regulation of Dyrk1A: towards understanding Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cellular and molecular life sciences : CMLS 2009-08-14 Down syndrome and Alzheimer's

    Down syndrome (DS) is associated with a variety of symptoms, such as incapacitating mental retardation and neurodegeneration (i.e., Alzheimer's disease), that prevent patients from leading fully independent lives.

From across this topic

9 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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