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Home › Research › Topic

Disease mechanisms in lab and animal studies

1,352 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Signal transduction and targeted therapy 2024-08-23 Treatments

    Alzheimer's disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges.

  2. Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular neurodegeneration 2024-01-18 Drug development

    Considering these results, combination of mitochondria-targeted compounds with other anti-amyloid beta or anti-tau therapies hold promise as neuroprotective drugs for the prevention and/or treatment of AD.

  3. Synthesis and Bioevaluation of 2-Styrylquinoxaline Derivatives as Tau-PET Tracers

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular pharmaceutics 2023-10-18 Drug development

    This study focused on designing and evaluating Tau-PET tracers for noninvasive positron emission computed tomography (PET) imaging of neurofibrillary tangles (NFTs), a hallmark pathology of Alzheimer's disease (AD).

  4. Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2023-10-03 Disease mechanisms

    Alzheimer's disease, the most common cause of dementia, is a chronic degenerative disease with typical pathological features of extracellular senile plaques and intracellular neurofibrillary tangles and a significant decrease in the density of neuronal dendritic spines.

  5. HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-08-22 Brain tissue and pathology

    Parkinson disease (PD) is closely linked to the misfolding and accumulation of α-synuclein (α-syn) into Lewy bodies.

  6. Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-05-29 Genetics

    Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network.

  7. Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2022-08-27 Disease mechanisms

    Synaptic dysfunction is an early mechanism in Alzheimer's disease that involves progressively larger areas of the brain over time.

  8. Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature medicine 2021-12-23 Drug development

    Expansions of a G 4 C 2 repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders.

  9. Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular psychiatry 2021-10-25 Disease mechanisms

    TDP-43 proteinopathy is linked to neurodegenerative diseases that feature synaptic loss in the cortex and hippocampus, although it remains unclear how TDP-43 regulates mature synapses.

  10. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2020-04-17 Digital health tools

    In addition to Aβ and tau, ANXA5, VGF, GPM6A, and ACTZ are new signature proteins in AD EVs.

  11. Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2020-03-13 Biomarkers

    The relationship between amyloid-β (Aβ) species and tau pathology in Alzheimer's disease (AD) is not fully understood.

  12. From the prion-like propagation hypothesis to therapeutic strategies of anti-tau immunotherapy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica 2019-11-04 Drug development

    The term "propagon" is used to define proteins that may transmit misfolding in vitro, in tissues or in organisms.

  13. Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2019-10-29 Vascular contributions

    The formation of Aβ amyloid fibrils is a neuropathological hallmark of Alzheimer's disease and cerebral amyloid angiopathy.

  14. Prevention of tau seeding and propagation by immunotherapy with a central tau epitope antibody

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2019-06-01 Drug development

    Tauopathies are neurodegenerative diseases characterized by the intraneuronal accumulation of aggregated tau.

  15. Familial Alzheimer's disease patient-derived neurons reveal distinct mutation-specific effects on amyloid beta

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular psychiatry 2019-04-12 Biomarkers

    Familial Alzheimer's disease (fAD) mutations alter amyloid precursor protein (APP) cleavage by γ-secretase, increasing the proportion of longer amyloidogenic amyloid-β (Aβ) peptides.

  16. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. eLife 2019-03-25 Brain scans and imaging

    Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas.

  17. Tau PET imaging in neurodegenerative tauopathies-still a challenge

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular psychiatry 2019-01-11 Brain scans and imaging

    The accumulation of pathological misfolded tau is a feature common to a collective of neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is the most common.

  18. A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature neuroscience 2018-12-17 Genetics

    Excitatory neurons are preferentially impaired in early Alzheimer's disease but the pathways contributing to their relative vulnerability remain largely unknown.

  19. Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2018-10-31 Disease mechanisms

    Protein misfolding is linked to a wide array of human disorders, including Alzheimer's disease, Parkinson's disease and type II diabetes1,2.

  20. Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica 2018-09-20 Drug development

    In Alzheimer's disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration.

  21. Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2018-08-01 Down syndrome and Alzheimer's

    Down syndrome, caused by trisomy of chromosome 21, is the single most common risk factor for early-onset Alzheimer's disease.

  22. Tau positron emission tomography imaging in tauopathies: The added hurdle of off-target binding

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2018-02-23 Brain scans and imaging

    Ligands targeting tau for use with positron emission tomography have rapidly been developed during the past several years, enabling the in vivo study of tau pathology in patients with Alzheimer's disease and related non-Alzheimer's disease tauopathies.

  23. Brains with sporadic Creutzfeldt-Jakob disease and copathology showed a prolonged end-stage of disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of clinical pathology 2017-11-02 Brain tissue and pathology

    Copathology was significantly associated with survival in brains with CJD (4.2±1.2 vs 9.2±1.9; P=0.019) and in brains with MM1/MV1 CJD (2.1±1.0 vs 6.7±2.8; P=0.012).

  24. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2017-10-17 Drug development

    Traumatic brain injury (TBI) is characterized by acute neurological dysfunction and associated with the development of chronic traumatic encephalopathy (CTE) and Alzheimer's disease.

  25. Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2017-05-01 Drug development

    Alzheimer's disease is characterized by the deposition of amyloid-β as extracellular plaques and hyperphosphorylated tau as intracellular neurofibrillary tangles.

From across this topic

10 of the 1,352 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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