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The interplay between oxidative stress and autophagy: focus on the development of neurological diseases
Marjan Talebi, Seyyed Ali Mohammadi Vadoud, Alireza Haratian, Mohsen Talebi, Tahereh Farkhondeh, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian. Behavioral and brain functions : BBF, 2022-01-29
Topic: Disease mechanisms in lab and animal studies
Regarding the epidemiological studies, neurological dysfunctions caused by cerebral ischemia or neurodegenerative diseases (NDDs) have been considered a pointed matter. Mount-up shreds of evidence support that both autophagy and reactive oxygen species (ROS) are involved in the commencement and progression of neurological diseases. Remarkably, oxidative stress prompted by an increase of ROS threatens cerebral integrity and improves the severity of other pathogenic agents such as mitochondrial damage in neuronal disturbances. Autophagy is anticipated as a cellular defending mode to combat cytotoxic substances and damage. The recent document proposes that the interrelation of autophagy and ROS creates a crucial function in controlling neuronal homeostasis. This review aims to overview the cross-talk among autophagy and oxidative stress and its molecular mechanisms in various neurological diseases to prepare new perceptions into a new treatment for neurological disorders. Furthermore, natural/synthetic agents entailed in modulation/regulation of this ambitious cross-talk are described.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Talebi, M., Vadoud, S. A. M., Haratian, A., Talebi, M., Farkhondeh, T., Pourbagher-Shahri, A. M., et al. (2022). The interplay between oxidative stress and autophagy: focus on the development of neurological diseases. Behavioral and brain functions : BBF. https://doi.org/10.1186/s12993-022-00187-3
Vancouver
Talebi M, Vadoud SAM, Haratian A, Talebi M, Farkhondeh T, Pourbagher-Shahri AM, et al. The interplay between oxidative stress and autophagy: focus on the development of neurological diseases. Behavioral and brain functions : BBF. 2022. doi:10.1186/s12993-022-00187-3. PMID: 35093121.
BibTeX
@article{talebi2022-35093121,
author = {Talebi, Marjan and Vadoud, Seyyed Ali Mohammadi and Haratian, Alireza and Talebi, Mohsen and Farkhondeh, Tahereh and Pourbagher-Shahri, Ali Mohammad and Samarghandian, Saeed},
title = {{The interplay between oxidative stress and autophagy: focus on the development of neurological diseases}},
journal = {Behavioral and brain functions : BBF},
year = {2022},
doi = {10.1186/s12993-022-00187-3},
pmid = {35093121},
url = {https://doi.org/10.1186/s12993-022-00187-3}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Remarkably, oxidative stress prompted by an increase of ROS threatens cerebral integrity and improves the severity of other pathogenic agents such as mitochondrial damage in neuronal disturbances.
- Autophagy is anticipated as a cellular defending mode to combat cytotoxic substances and damage.
- The recent document proposes that the interrelation of autophagy and ROS creates a crucial function in controlling neuronal homeostasis.
- This review aims to overview the cross-talk among autophagy and oxidative stress and its molecular mechanisms in various neurological diseases to prepare new perceptions into a new treatment for neurological disorders.
- Furthermore, natural/synthetic agents entailed in modulation/regulation of this ambitious cross-talk are described.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 23 of the 56 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Behavioral and brain functions : BBF) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 35093121) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 23 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 23 of the 56 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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