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The epidemiology of frontotemporal dementia
Onyike CU, Diehl-Schmid J.. International review of psychiatry (Abingdon, England), 2013-04-01
Topic: Risk, prevention and care in population studies
Frontotemporal dementia, a heterogeneous neurodegenerative disorder, is a common cause of young onset dementia (i.e. dementia developing in midlife or earlier). The estimated point prevalence is 15-22/100,000, and incidence 2.7-4.1/100,000. Some 25% are late-life onset cases. Population studies show nearly equal distribution by gender, which contrasts with myriad clinical and neuropathology reports. FTD is frequently familial and hereditary; five genetic loci for causal mutations have been identified, all showing 100% penetrance. Non-genetic risk factors are yet to be identified. FTD shows poor life expectancy but with survival comparable to that of Alzheimer's disease. Recent progress includes the formulation of up-to-date diagnostic criteria for the behavioural and language variants, and the development of new and urgently needed instruments for monitoring and staging the illness. There is still need for descriptive population studies to fill gaps in our knowledge about minority groups and developing regions. More pressing, however, is the need for reliable physiological markers for disease. There is a present imperative to develop a translational science to form the conduit for transferring neurobiological discoveries and insights from bench to bedside.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Onyike, C. U., & Diehl-Schmid, J. (2013). The epidemiology of frontotemporal dementia. International review of psychiatry (Abingdon, England). https://doi.org/10.3109/09540261.2013.776523
Vancouver
Onyike CU, Diehl-Schmid J. The epidemiology of frontotemporal dementia. International review of psychiatry (Abingdon, England). 2013. doi:10.3109/09540261.2013.776523. PMID: 23611343.
BibTeX
@article{onyike2013-23611343,
author = {Onyike, C. U. and Diehl-Schmid, J.},
title = {{The epidemiology of frontotemporal dementia}},
journal = {International review of psychiatry (Abingdon, England)},
year = {2013},
doi = {10.3109/09540261.2013.776523},
pmid = {23611343},
url = {https://doi.org/10.3109/09540261.2013.776523}
}
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Key findings
- FTD shows poor life expectancy but with survival comparable to that of Alzheimer's disease.
- Recent progress includes the formulation of up-to-date diagnostic criteria for the behavioural and language variants, and the development of new and urgently needed instruments for monitoring and staging the illness.
- There is still need for descriptive population studies to fill gaps in our knowledge about minority groups and developing regions.
- More pressing, however, is the need for reliable physiological markers for disease.
- There is a present imperative to develop a translational science to form the conduit for transferring neurobiological discoveries and insights from bench to bedside.
Why it matters
This review describes the frequency, inheritance and poor survival of frontotemporal dementia and notes that reliable markers of the disease are still needed. It reports no treatment or cure and identifies no non-genetic risk factors.
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Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International review of psychiatry (Abingdon, England)) |
| Journal's citation record | 1 / 4 | International Review of Psychiatry: journal h-index 136 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 544 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 36.3 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 4 / 6 | Cited 17.7× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 4 / 6 | Cited by 33 other studies in this library |
| Still being cited | 3 / 4 | Cited 123 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Janine Diehl‐Schmid: h-index 57 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Johns Hopkins University: institution h-index 2,306 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23611343) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
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Read the original
- DOI: 10.3109/09540261.2013.776523
- PubMed: 23611343
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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