This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Prevention trials

Topic: Risk, prevention and care in population studies

Aims To identify subgroups who may be more likely to respond well to a multidomain intervention among older adults with type 2 diabetes. Materials and methods This study was a secondary analysis of the Japan Multimodal Intervention Trial for Prevention of Dementia. A total 531 participants aged 65–85 years with mild cognitive impairment were randomized into intervention (vascular risk management, exercise, nutritional counseling, and cognitive training) and control (health-related information) groups. The outcome was the change in average Z scores of neuropsychological tests from baseline to 18 months. Interactions between intervention and age (65–74, 75–85 years), memory impairment (amnestic, nonamnestic), HbA1c levels (within, outside target range), or APOE genotype (0, ≥1 APOE ε4 alleles) among participants with diabetes were evaluated using the mixed‐effects model for repeated measures. Results Among 76 participants with diabetes, a significant age × intervention interaction ( P = 0.007) was found, which was driven by benefits in the younger age group (Z score difference: 0.33, 95% CI: 0.09 to 0.55) that were not observed in the older age group. Intervention benefits were also detected in those with HbA1c levels outside the target range (Z score difference: 0.31, 95% CI: 0.06 to 0.56), with HbA1c levels × intervention interaction ( P = 0.021). No significant interactions were detected between intervention and memory impairment or APOE genotype. Conclusions Multidomain interventions may benefit younger older adults or those with overly strict or lenient HbA1c control; however, these findings need confirmation in future studies.

Key findings

Results Among 76 participants with diabetes, a significant age × intervention interaction ( P = 0.007) was found, which was driven by benefits in the younger age group (Z score difference: 0.33, 95% CI: 0.09 to 0.55) that were not observed in the older age group.
No significant interactions were detected between intervention and memory impairment or APOE genotype.
Conclusions Multidomain interventions may benefit younger older adults or those with overly strict or lenient HbA1c control; however, these findings need confirmation in future studies.

Why it matters

In this secondary analysis of 76 participants with type 2 diabetes and mild cognitive impairment, multidomain intervention benefits were seen in the younger age group and in those with HbA1c outside the target range, but not in the older group. No significant interactions were found for memory impairment or APOE genotype, and the authors call for further study.

New to this subject? Start with our plain-English guide: Prevention →

Study details

Participants531
Evidence strengthHigh

How this study scored 48/100

Published in a peer-reviewed journal. Scored zero for study design and effect reported because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Aging Research and Lifestyle)
Journal's citation record	0 / 4	Journal of Aging Research and Lifestyle: journal h-index 13 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	5 / 5	Rated “high” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	2 / 4	531 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	1 / 2	Randomised (as stated in the record)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Takashi Sakurai: h-index 45 (OpenAlex, whole career)
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 7 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40546712)
Free to read	2 / 2	Free to read
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Sugimoto, T., Crane, P. K., Choi, S., Fujita, K., Gallée, J., Kuroda, Y., et al. (2025). Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT. Journal of Aging Research and Lifestyle. https://doi.org/10.1016/j.jarlif.2025.100016

Vancouver

Sugimoto T, Crane PK, Choi S, Fujita K, Gallée J, Kuroda Y, et al. Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT. Journal of Aging Research and Lifestyle. 2025. doi:10.1016/j.jarlif.2025.100016. PMID: 40546712.

BibTeX

@article{sugimoto2025-40546712,
  author  = {Sugimoto, Taiki and Crane, Paul K. and Choi, Seo‐Eun and Fujita, Kosuke and Gallée, Jeanne and Kuroda, Yujiro and Lee, Michael K. and Matsumoto, Nanae and others},
  title   = {{Multidomain interventions for preventing cognitive decline in older adults with type 2 diabetes and mild cognitive impairment: Secondary analysis of the J-MINT}},
  journal = {Journal of Aging Research and Lifestyle},
  year    = {2025},
  doi     = {10.1016/j.jarlif.2025.100016},
  pmid    = {40546712},
  url     = {https://doi.org/10.1016/j.jarlif.2025.100016}
}

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 15.

Related studies in Prevention trials

Similar studies

More on Prevention trials

See all studies in Prevention trials →