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Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study
de Lau LM, Schipper CM, Hofman A, Koudstaal PJ, Breteler MM.. Archives of neurology, 2005-08-01
Topic: Risk, prevention and care in population studies
Background Most prognostic studies on Parkinson disease have been hospital based or have applied register-based case-finding methods. Potential under-representation of mild cases may have given biased results. Objective To evaluate whether Parkinson disease is associated with an increased risk of dementia and death.
Key findings
- Potential under-representation of mild cases may have given biased results.
- Objective To evaluate whether Parkinson disease is associated with an increased risk of dementia and death.
- Parkinson disease and dementia were assessed through in-person examination at baseline (1990-1993) and 2 follow-up visits (1993-1994 and 1997-1999).
- Computerized linkage to medical and municipality records provided additional information on disease outcomes and mortality.
Why it matters
This study evaluated whether Parkinson disease is associated with an increased risk of dementia and death in a population cohort. It concerns Parkinson disease, not Alzheimer's disease, and being observational it cannot show how to prevent dementia.
Study details
- Study designcohort study
- Participants6,969
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | 3 / 4 | Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2005 — older than 20 years, still counted |
| Sample size | 3 / 4 | 6,969 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 211 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 9.2 citations a year over 23 year(s) since 2005 |
| Impact for its field and year | 3 / 6 | Cited 5.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 2 / 4 | Cited 17 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Monique M.B. Breteler: h-index 162 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16087767) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
de Lau, L. M., Schipper, C. M., Hofman, A., Koudstaal, P. J., & Breteler, M. M. (2005). Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study. Archives of neurology. https://doi.org/10.1001/archneur.62.8.1265
Vancouver
de Lau LM, Schipper CM, Hofman A, Koudstaal PJ, Breteler MM. Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study. Archives of neurology. 2005. doi:10.1001/archneur.62.8.1265. PMID: 16087767.
BibTeX
@article{delau2005-16087767,
author = {de Lau, L. M. and Schipper, C. M. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
title = {{Prognosis of Parkinson disease: risk of dementia and mortality: the Rotterdam Study}},
journal = {Archives of neurology},
year = {2005},
doi = {10.1001/archneur.62.8.1265},
pmid = {16087767},
url = {https://doi.org/10.1001/archneur.62.8.1265}
}
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