Home › Research › Long-term cohort studies
Association Between Atrial Fibrillation and Dementia in the General Population
de Bruijn RF, Heeringa J, Wolters FJ, Franco OH, Stricker BH, Hofman A, Koudstaal PJ, Ikram MA.. JAMA neurology, 2015-11-01
Topic: Amyloid, tau and blood-test diagnosis
Importance Atrial fibrillation (AF) has been suggested as a risk factor for dementia since it may lead to chronic cerebral hypoperfusion and stroke. However, longitudinal studies assessing the association between AF and dementia have shown inconsistent results. Objective To determine the effect of AF on the risk of developing dementia during 20 years of follow-up.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
de Bruijn, R. F., Heeringa, J., Wolters, F. J., Franco, O. H., Stricker, B. H., Hofman, A., et al. (2015). Association Between Atrial Fibrillation and Dementia in the General Population. JAMA neurology. https://doi.org/10.1001/jamaneurol.2015.2161
Vancouver
de Bruijn RF, Heeringa J, Wolters FJ, Franco OH, Stricker BH, Hofman A, et al. Association Between Atrial Fibrillation and Dementia in the General Population. JAMA neurology. 2015. doi:10.1001/jamaneurol.2015.2161. PMID: 26389654.
BibTeX
@article{debruijn2015-26389654,
author = {de Bruijn, R. F. and Heeringa, J. and Wolters, F. J. and Franco, O. H. and Stricker, B. H. and Hofman, A. and Koudstaal, P. J. and Ikram, M. A.},
title = {{Association Between Atrial Fibrillation and Dementia in the General Population}},
journal = {JAMA neurology},
year = {2015},
doi = {10.1001/jamaneurol.2015.2161},
pmid = {26389654},
url = {https://doi.org/10.1001/jamaneurol.2015.2161}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- However, longitudinal studies assessing the association between AF and dementia have shown inconsistent results.
- Objective To determine the effect of AF on the risk of developing dementia during 20 years of follow-up.
- Design, setting, and participants The association of prevalent and incident AF with incident dementia was assessed from July 6, 1989, to February 4, 2010, in 6514 dementia-free participants in the prospective population-based Rotterdam Study.
- Data analysis was conducted from September 18, 2014, to April 17, 2015.
Why it matters
This study examined whether atrial fibrillation, a heart rhythm problem, is linked to developing dementia over 20 years in 6,514 dementia-free participants. If atrial fibrillation raises dementia risk, treating it could be a prevention strategy, but this study only assessed the association.
Study details
- Study designlongitudinal study
- Participants6,514
- Effect size4.9%; 15.3%; 11.7%
- Evidence strengthModerate
How this study scored 65/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (JAMA neurology) |
| Journal's citation record | 2 / 4 | JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 3 / 4 | 6,514 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 278 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 21.4 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 4 / 6 | Cited 16.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 3 / 4 | Cited 71 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author M. Arfan Ikram: h-index 167 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Erasmus MC: institution h-index 1,321 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26389654) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 65 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 16.
Later studies that cite this one
7 studies in the alzhub library list this one in their references.
Related studies in Long-term cohort studies
Also tagged “incidence”
1,084 studies in the library carry the topic tag “incidence”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,084 tagged studies.