Home › Research › Mild cognitive impairment
The role of event-related potentials in cognitive decline in Alzheimer's disease
Lai CL, Lin RT, Liou LM, Liu CK.. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2009-12-11
Topic: Amyloid, tau and blood-test diagnosis
Objectives Early diagnosis and monitoring of disease progression have become vital in clinical practice as disease modifying treatments for Alzheimer's disease (AD) become available. This one-year prospective study aimed to clarify the usefulness of event-related potentials (ERPs) in cognitive decline and elucidate their cognitive significance in AD. Methods Using the Cognitive Abilities Screening Instrument (CASI) and ERPs, probable AD patients, mild cognitive impairment (MCI) patients, and normal controls were recruited. Results The AD and MCI patients had significantly decreased cognitive function and manifested a delay of P300 latency. The P300 latencies demonstrated significantly more prolongation than their baseline values in probable AD and MCI patients, although their CASI scores showed no statistically significant decline. Whereas N100, P200, and N200 components did not reach statistical differences between groups either in the baseline or follow-up assessments and did not show significant change on follow-up. Conclusion The combination of neuropsychological tests and P300 measurements proved useful in improving reliability and increasing sensitivity to early cognitive decline or disease progression in AD patients. Significance The P300 latency may reflect cognitive decline more sensitively than neuropsychological tests in the longitudinal follow-up of AD patients.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lai, C. L., Lin, R. T., Liou, L. M., & Liu, C. K. (2010). The role of event-related potentials in cognitive decline in Alzheimer's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. https://doi.org/10.1016/j.clinph.2009.11.001
Vancouver
Lai CL, Lin RT, Liou LM, Liu CK. The role of event-related potentials in cognitive decline in Alzheimer's disease. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2010. doi:10.1016/j.clinph.2009.11.001. PMID: 20005164.
BibTeX
@article{lai2010-20005164,
author = {Lai, C. L. and Lin, R. T. and Liou, L. M. and Liu, C. K.},
title = {{The role of event-related potentials in cognitive decline in Alzheimer's disease}},
journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
year = {2010},
doi = {10.1016/j.clinph.2009.11.001},
pmid = {20005164},
url = {https://doi.org/10.1016/j.clinph.2009.11.001}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Results The AD and MCI patients had significantly decreased cognitive function and manifested a delay of P300 latency.
- The P300 latencies demonstrated significantly more prolongation than their baseline values in probable AD and MCI patients, although their CASI scores showed no statistically significant decline.
- Whereas N100, P200, and N200 components did not reach statistical differences between groups either in the baseline or follow-up assessments and did not show significant change on follow-up.
Why it matters
In this one-year study, P300 latency became more prolonged in people with probable Alzheimer's disease and mild cognitive impairment even though their cognitive test scores did not significantly decline. This suggests P300 may be a sensitive measure of cognitive decline, but no treatment was tested.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 49/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology) |
| Journal's citation record | 2 / 4 | Clinical Neurophysiology: journal h-index 247 (OpenAlex, 2026-10-29) |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2010 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 141 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.8 citations a year over 18 year(s) since 2010 |
| Impact for its field and year | 3 / 6 | Cited 4.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 2 / 4 | Cited 19 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Ching‐Kuan Liu: h-index 29 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Kaohsiung Medical University: institution h-index 330 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 3 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 20005164) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Related
Studies in the library that share something with this one. The line above each title says what.
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
4 studies in the alzhub library list this one in their references.
Related studies in Mild cognitive impairment
Also in Mild cognitive impairment
76 studies in the library are filed under Mild cognitive impairment with no topic tag they share with another; these are this study's neighbours in a fixed tour of them. The Mild cognitive impairment hub.