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Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study
Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, Miyamoto T, Oertel W et al.. Annals of neurology, 2015-03-13
Topic: Brain proteins, microglia and lab models
Plain-language summary
Objective To assess whether risk factors for Parkinson disease and dementia with Lewy bodies increase rate of defined neurodegenerative disease in idiopathic rapid eye movement (REM) sleep behavior disorder (RBD). Methods Twelve centers administered a detailed questionnaire assessing risk factors for neurodegenerative synucleinopathy to patients with idiopathic RBD. Variables included demographics, lifestyle factors, pesticide exposures, occupation, comorbid conditions, medication use, family history, and autonomic/motor symptoms. After 4 years of follow-up, patients were assessed for dementia or parkinsonism. Disease risk was assessed with Kaplan-Meier analysis, and epidemiologic variables were compared between convertors and those still idiopathic using logistic regression. Results Of 305 patients, follow-up information was available for 279, of whom 93 (33.3%) developed defined neurodegenerative disease. Disease risk was 25% at 3 years and 41% after 5 years. Patients who converted were older (difference = 4.5 years, p Interpretation Patients with idiopathic RBD are at very high risk of neurodegenerative synucleinopathy. Risk factor profiles between convertors and nonconvertors have both important commonalities and differences.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Postuma, R. B., Iranzo, A., Hogl, B., Arnulf, I., Ferini-Strambi, L., Manni, R., et al. (2015). Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study. Annals of neurology. https://doi.org/10.1002/ana.24385
Vancouver
Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, et al. Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study. Annals of neurology. 2015. doi:10.1002/ana.24385. PMID: 25767079.
BibTeX
@article{postuma2015-25767079,
author = {Postuma, R. B. and Iranzo, A. and Hogl, B. and Arnulf, I. and Ferini-Strambi, L. and Manni, R. and Miyamoto, T. and Oertel, W. and others},
title = {{Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study}},
journal = {Annals of neurology},
year = {2015},
doi = {10.1002/ana.24385},
pmid = {25767079},
url = {https://doi.org/10.1002/ana.24385}
}
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Key findings
- Results Of 305 patients, follow-up information was available for 279, of whom 93 (33.3%) developed defined neurodegenerative disease.
Why it matters
In this multicenter study, 33.3% of patients with idiopathic REM sleep behavior disorder developed a defined neurodegenerative disease over follow-up, with risk reaching 41% after 5 years. This identifies a high-risk group but does not test any treatment or prevention.
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Study details
- Participants305
- Effect size33.3%
- Evidence strengthLow
How this study scored 60/100
Published in a leading specialty journal. Scored zero for study design and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Annals of neurology) |
| Journal's citation record | 3 / 4 | Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 305 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 293 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 22.5 citations a year over 13 year(s) since 2015 |
| Impact for its field and year | 5 / 6 | Cited 26.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 5 other studies in this library |
| Still being cited | 2 / 4 | Cited 37 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Jacques Yves Montplaisir: h-index 117 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multicenter collaboration | 3 / 3 | OpenAlex lists 21 institution(s) in 9 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25767079) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 60 / 100 | — |
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