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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Digital health tools

Topic: Risk, prevention and care in population studies

Plain-language summary

Background The temporal variant of frontotemporal dementia (tvFTD) features asymmetric anterior temporal/amygdala degeneration as well as ventromedial frontal, insular, and inferoposterior temporal involvement. Left temporal atrophy has been linked to loss of semantic knowledge, whereas behavioral symptoms dominate the right temporal variant. Objective To investigate the first symptoms and the timing of subsequent symptoms in patients with left versus right tvFTD. Methods Twenty-six patients with tvFTD were identified. Six had right > left temporal atrophy (right temporal lobe variant [RTLV]) and were matched with six having comparable left > right temporal atrophy (left temporal lobe variant [LTLV]). Clinical records were reviewed to generate individualized symptom chronologies. Results In all patients, first symptoms involved semantics (4/6 LTLV, 1/6 RTLV), behavior (4/6 RTLV, 1/6 LTLV), or both (1 LTLV, 1 RTLV). Semantic loss began with anomia, word-finding difficulties, and repetitive speech, whereas the early behavioral syndrome was characterized by emotional distance, irritability, and disruption of physiologic drives (sleep, appetite, libido). After an average of 3 years, patients developed whichever of the two initial syndromes--semantic or behavioral--that they lacked at onset. A third stage, 5 to 7 years from onset, saw the emergence of disinhibition, compulsions, impaired face recognition, altered food preference, and weight gain. Compulsions in LTLV were directed toward visual, nonverbal stimuli, whereas patients with RTLV were drawn to games with words and symbols. Conclusions The temporal variant of frontotemporal dementia follows a characteristic cognitive and behavioral progression that suggests early spread from one anterior temporal lobe to the other. Later symptoms implicate ventromedial frontal, insular, and inferoposterior temporal regions, but their precise anatomic correlates await confirmation.

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APA 7th

Seeley, W. W., Bauer, A. M., Miller, B. L., Gorno-Tempini, M. L., Kramer, J. H., Weiner, M., et al. (2005). The natural history of temporal variant frontotemporal dementia. Neurology. https://doi.org/10.1212/01.wnl.0000158425.46019.5c

Vancouver

Seeley WW, Bauer AM, Miller BL, Gorno-Tempini ML, Kramer JH, Weiner M, et al. The natural history of temporal variant frontotemporal dementia. Neurology. 2005. doi:10.1212/01.wnl.0000158425.46019.5c. PMID: 15851728.

BibTeX

@article{seeley2005-15851728,
  author  = {Seeley, W. W. and Bauer, A. M. and Miller, B. L. and Gorno-Tempini, M. L. and Kramer, J. H. and Weiner, M. and Rosen, H. J.},
  title   = {{The natural history of temporal variant frontotemporal dementia}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000158425.46019.5c},
  pmid    = {15851728},
  url     = {https://doi.org/10.1212/01.wnl.0000158425.46019.5c}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

How to read this study

Design: our record does not state a study design, so check the methods section of the original before weighing the result.
Size: the record gives no participant count. Look for one in the original before trusting a pattern.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded low. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Low means the abstract matched neither pattern. It is the default label, and it does not mean the work is poor; many sound lab and imaging papers land here. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Objective To investigate the first symptoms and the timing of subsequent symptoms in patients with left versus right tvFTD.
Results In all patients, first symptoms involved semantics (4/6 LTLV, 1/6 RTLV), behavior (4/6 RTLV, 1/6 LTLV), or both (1 LTLV, 1 RTLV).

Why it matters

This study of 26 patients with temporal variant frontotemporal dementia found that first symptoms involved semantics or behavior depending on whether atrophy was left- or right-sided, with additional symptoms emerging over time. It describes the natural history of this condition and does not test any treatment, cure, or prevention for Alzheimer's disease.

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Study details

Evidence strengthLow

How this study scored 52/100

Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Neurology)
Journal's citation record	4 / 4	Neurology: journal h-index 525 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2005 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 346 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	15.0 citations a year over 23 year(s) since 2005
Impact for its field and year	4 / 6	Cited 8.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 23 other studies in this library
Still being cited	2 / 4	Cited 43 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Howard J. Rosen: h-index 102 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, San Francisco: institution h-index 1,915 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 15851728)
Free to read	0 / 2	Behind a paywall — scores zero
Total	52 / 100	—

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