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52/100

✓ Peer-reviewed alzhub usefulness score 52 out of 100. Getting a diagnosis

Topic: Risk, prevention and care in population studies

A diagnosis of dementia is devastating at any age but diagnosis in younger patients presents a particular challenge. The differential diagnosis is broad as late presentation of metabolic disease is common and the burden of inherited dementia is higher in these patients than in patients with late-onset dementia. The presentation of the common degenerative diseases of late life, such as Alzheimer's disease, can be different when presenting in the fifth or sixth decade. Moreover, many of the young-onset dementias are treatable. The identification of causative genes for many of the inherited degenerative dementias has led to an understanding of the molecular pathology, which is also applicable to later-onset sporadic disease. This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Rossor, M. N., Fox, N. C., Mummery, C. J., Schott, J. M., & Warren, J. D. (2010). The diagnosis of young-onset dementia. The Lancet. Neurology. https://doi.org/10.1016/s1474-4422(10)70159-9

Vancouver

Rossor MN, Fox NC, Mummery CJ, Schott JM, Warren JD. The diagnosis of young-onset dementia. The Lancet. Neurology. 2010. doi:10.1016/s1474-4422(10)70159-9. PMID: 20650401.

BibTeX

@article{rossor2010-20650401,
  author  = {Rossor, M. N. and Fox, N. C. and Mummery, C. J. and Schott, J. M. and Warren, J. D.},
  title   = {{The diagnosis of young-onset dementia}},
  journal = {The Lancet. Neurology},
  year    = {2010},
  doi     = {10.1016/s1474-4422(10)70159-9},
  pmid    = {20650401},
  url     = {https://doi.org/10.1016/s1474-4422(10)70159-9}
}

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Key findings

The differential diagnosis is broad as late presentation of metabolic disease is common and the burden of inherited dementia is higher in these patients than in patients with late-onset dementia.
The presentation of the common degenerative diseases of late life, such as Alzheimer's disease, can be different when presenting in the fifth or sixth decade.
Moreover, many of the young-onset dementias are treatable.
The identification of causative genes for many of the inherited degenerative dementias has led to an understanding of the molecular pathology, which is also applicable to later-onset sporadic disease.
This understanding offers the potential for future treatments to be tailored to a specific diagnosis of both young-onset and late-onset dementia.

Why it matters

This review states that diagnosing young-onset dementia is particularly challenging because the differential diagnosis is broad, late presentation of metabolic disease is common, and the burden of inherited dementia is higher than in late-onset dementia, and that many young-onset dementias are treatable. It also notes that identifying causative genes for inherited degenerative dementias has increased understanding of the molecular pathology, offering potential for future treatments tailored to a specific diagnosis.

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Study details

Evidence strengthLow

How this study scored 52/100

Published in a leading specialty journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (The Lancet. Neurology)
Journal's citation record	3 / 4	The Lancet Neurology: journal h-index 457 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 586 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	32.6 citations a year over 18 year(s) since 2010
Impact for its field and year	4 / 6	Cited 11.2× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 28 other studies in this library
Still being cited	3 / 4	Cited 132 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Jason D. Warren: h-index 95 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20650401)
Free to read	0 / 2	Behind a paywall — scores zero
Total	52 / 100	—

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