Home › Research › Long-term cohort studies
Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank
Jacobs BM, Belete D, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, Dobson R, Nalls MA et al.. Journal of neurology, neurosurgery, and psychiatry, 2020-10-01
Topic: Brain proteins, microglia and lab models
Objective To systematically investigate the association of environmental risk factors and prodromal features with incident Parkinson's disease (PD) diagnosis and the interaction of genetic risk with these factors. To evaluate whether existing risk prediction algorithms are improved by the inclusion of genetic risk scores. Methods We identified individuals with an incident diagnosis of PD (n=1276) and controls (n=500 406) in UK Biobank.
Key findings
- To evaluate whether existing risk prediction algorithms are improved by the inclusion of genetic risk scores.
- Methods We identified individuals with an incident diagnosis of PD (n=1276) and controls (n=500 406) in UK Biobank.
- We determined the association of risk factors with incident PD using adjusted logistic regression models.
- We constructed polygenic risk scores (PRSs) using external weights and selected the best PRS from a subset of the cohort (30%).
Why it matters
This study investigated environmental and prodromal risk factors for Parkinson's disease and whether genetic risk scores improve prediction. It concerns Parkinson's disease, not Alzheimer's disease, and does not test any treatment, cure, or prevention for Alzheimer's.
Study details
- Participants1,276
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | 3 / 4 | Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,276 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 122 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 15.2 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 5.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 3 / 4 | Cited 65 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Alastair John Noyce: h-index 60 (OpenAlex, whole career) |
| Institution's track record | 3 / 3 | National Institutes of Health: institution h-index 2,723 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 7 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32934108) |
| Free to read | 2 / 2 | Free to read |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1136/jnnp-2020-323646
- PubMed: 32934108
- Original source →
- Free full text: Journal of Neurology Neurosurgery & Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Jacobs, B. M., Belete, D., Bestwick, J., Blauwendraat, C., Bandres-Ciga, S., Heilbron, K., et al. (2020). Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp-2020-323646
Vancouver
Jacobs BM, Belete D, Bestwick J, Blauwendraat C, Bandres-Ciga S, Heilbron K, et al. Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank. Journal of neurology, neurosurgery, and psychiatry. 2020. doi:10.1136/jnnp-2020-323646. PMID: 32934108.
BibTeX
@article{jacobs2020-32934108,
author = {Jacobs, B. M. and Belete, D. and Bestwick, J. and Blauwendraat, C. and Bandres-Ciga, S. and Heilbron, K. and Dobson, R. and Nalls, M. A. and others},
title = {{Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {2020},
doi = {10.1136/jnnp-2020-323646},
pmid = {32934108},
url = {https://doi.org/10.1136/jnnp-2020-323646}
}
Studies this one cites
Referenced by this study and also in the alzhub library, so you can read them here.
Later studies that cite this one
4 studies in the alzhub library list this one in their references.
Related studies in Long-term cohort studies
Also tagged “bodies”
1,017 studies in the library carry the topic tag “bodies”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 1,017 tagged studies.