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Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults
Lu WH, Giudici KV, Rolland Y, Guyonnet S, Li Y, Bateman RJ, de Souto Barreto P, Vellas B.. The journal of prevention of Alzheimer's disease, 2021-01-01
Topic: Amyloid, tau and blood-test diagnosis
Background Brain amyloid-beta (Aβ) plaques, a hallmark of the pathophysiology of Alzheimer's disease, have been associated with frailty. Whether the plasma Aβ markers show similar relationship with frailty is unknown. Objectives To investigate the prospective associations between plasma Aβ42/40 ratio and overtime frailty in community-dwelling older adults.
Key findings
- Whether the plasma Aβ markers show similar relationship with frailty is unknown.
- Objectives To investigate the prospective associations between plasma Aβ42/40 ratio and overtime frailty in community-dwelling older adults.
- Methods From the 5-year Multidomain Alzheimer Preventive Trial (MAPT), we included 477 adults ≥70 years with available data on plasma Aβ42/40 ratio (lower is worse).
- Fried frailty phenotype (robust, pre-frail and frail) was assessed at the same time-point of plasma Aβ measures and after until the end of follow-up.
Why it matters
This study looked at whether the plasma Aβ42/40 ratio predicted frailty over time in 477 community-dwelling older adults from the MAPT trial. It concerns frailty rather than Alzheimer's treatment, so it does not show how to treat, cure or prevent the disease.
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Study details
- Participants477
- Effect sizeHR=2.63; HR=3.48
- Evidence strengthLow
How this study scored 56/100
Published in a peer-reviewed journal, and it is a randomised controlled trial.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The journal of prevention of Alzheimer's disease) |
| Journal's citation record | 0 / 4 | The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 477 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 3 / 7 | Cited 17 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.4 citations a year over 7 year(s) since 2021 |
| Impact for its field and year | 1 / 6 | Cited 0.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Bruno Vellas: h-index 11 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Inserm: institution h-index 1,988 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 6 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33336223) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.14283/jpad.2020.60
- PubMed: 33336223
- Original source →
- Free full text: The Journal of Prevention of Alzheimer s Disease →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Lu, W. H., Giudici, K. V., Rolland, Y., Guyonnet, S., Li, Y., Bateman, R. J., et al. (2021). Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults. The journal of prevention of Alzheimer's disease. https://doi.org/10.14283/jpad.2020.60
Vancouver
Lu WH, Giudici KV, Rolland Y, Guyonnet S, Li Y, Bateman RJ, et al. Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults. The journal of prevention of Alzheimer's disease. 2021. doi:10.14283/jpad.2020.60. PMID: 33336223.
BibTeX
@article{lu2021-33336223,
author = {Lu, W. H. and Giudici, K. V. and Rolland, Y. and Guyonnet, S. and Li, Y. and Bateman, R. J. and de Souto Barreto, P. and Vellas, B.},
title = {{Prospective Associations between Plasma Amyloid-Beta 42/40 and Frailty in Community-Dwelling Older Adults}},
journal = {The journal of prevention of Alzheimer's disease},
year = {2021},
doi = {10.14283/jpad.2020.60},
pmid = {33336223},
url = {https://doi.org/10.14283/jpad.2020.60}
}
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