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Longitudinal Trajectories of the Cognitive Function Index in the A4 Study
Amariglio RE, Grill JD, Rentz DM, Marshall GA, Donohue MC, Liu A, Aisen PS, Sperling RA.. The journal of prevention of Alzheimer's disease, 2024-01-01
Topic: Risk, prevention and care in population studies
Results Both participant and study partner CFI increased over the duration of the study indicating worsening cognitive functioning. Results did not differ by treatment group. PACC had a significantly higher correlation with study partner CFI than with participant CFI by week 168.
Key findings
- Results Both participant and study partner CFI increased over the duration of the study indicating worsening cognitive functioning.
- Results did not differ by treatment group.
- PACC had a significantly higher correlation with study partner CFI than with participant CFI by week 168.
Why it matters
In the A4 study, cognitive function worsened over time for both participants and study partners, and this did not differ by treatment group. The study found no significant treatment effect on these cognitive measures.
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Study details
- Study designlongitudinal study
- Participants1,147
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The journal of prevention of Alzheimer's disease) |
| Journal's citation record | 0 / 4 | The Journal of Prevention of Alzheimer s Disease: journal h-index 63 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,147 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 3 / 7 | Cited 16 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 4.0 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 3 / 6 | Cited 4.4× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 3 other studies in this library |
| Still being cited | 2 / 4 | Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Reisa Anne Sperling: h-index 157 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Mass General Brigham: institution h-index 185 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | PubMed indexes it as a multicentre study |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39044492) |
| Free to read | 2 / 2 | Free to read |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.14283/jpad.2024.125
- PubMed: 39044492
- Original source →
- Free full text: The Journal of Prevention of Alzheimer s Disease →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Amariglio, R. E., Grill, J. D., Rentz, D. M., Marshall, G. A., Donohue, M. C., Liu, A., et al. (2024). Longitudinal Trajectories of the Cognitive Function Index in the A4 Study. The journal of prevention of Alzheimer's disease. https://doi.org/10.14283/jpad.2024.125
Vancouver
Amariglio RE, Grill JD, Rentz DM, Marshall GA, Donohue MC, Liu A, et al. Longitudinal Trajectories of the Cognitive Function Index in the A4 Study. The journal of prevention of Alzheimer's disease. 2024. doi:10.14283/jpad.2024.125. PMID: 39044492.
BibTeX
@article{amariglio2024-39044492,
author = {Amariglio, R. E. and Grill, J. D. and Rentz, D. M. and Marshall, G. A. and Donohue, M. C. and Liu, A. and Aisen, P. S. and Sperling, R. A.},
title = {{Longitudinal Trajectories of the Cognitive Function Index in the A4 Study}},
journal = {The journal of prevention of Alzheimer's disease},
year = {2024},
doi = {10.14283/jpad.2024.125},
pmid = {39044492},
url = {https://doi.org/10.14283/jpad.2024.125}
}
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