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Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease
Fedor Levin, Michel J Grothe, Martin Dyrba, Nicolai Franzmeier, Stefan J Teipel, Alzheimer’s Disease Neuroimaging Initiative. Neurobiology of aging, 2023-12-19
Topic: Brain imaging, connectivity and assessment
Previous studies have demonstrated resilience to AD-related neuropathology in a form of cognitive reserve (CR). In this study we investigated a relationship between CR and hypometabolic subtypes of AD, specifically the typical and the limbic-predominant subtypes. We analyzed data from 59 Aβ-positive cognitively normal (CN), 221 prodromal Alzheimer's disease (AD) and 174 AD dementia participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) from ADNI and ADNIGO/2 phases. For replication, we analyzed data from 5 Aβ-positive CN, 89 prodromal AD and 43 AD dementia participants from ADNI3. CR was estimated as standardized residuals in a model predicting cognition from temporoparietal grey matter volumes and covariates. Higher CR estimates predicted slower cognitive decline. Typical and limbic-predominant hypometabolic subtypes demonstrated similar baseline CR, but the results suggested a faster decline of CR in the typical subtype. These findings support the relationship between subtypes and CR, specifically longitudinal trajectories of CR. Results also underline the importance of longitudinal analyses in research on CR.
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APA 7th
Levin, F., Grothe, M. J., Dyrba, M., Franzmeier, N., Teipel, S. J., & Alzheimer’s Disease Neuroimaging Initiative. (2024). Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2023.12.003
Vancouver
Levin F, Grothe MJ, Dyrba M, Franzmeier N, Teipel SJ, Alzheimer’s Disease Neuroimaging Initiative. Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease. Neurobiology of aging. 2024. doi:10.1016/j.neurobiolaging.2023.12.003. PMID: 38157587.
BibTeX
@article{levin2024-38157587,
author = {Levin, Fedor and Grothe, Michel J and Dyrba, Martin and Franzmeier, Nicolai and Teipel, Stefan J and {Alzheimer’s Disease Neuroimaging Initiative}},
title = {{Longitudinal trajectories of cognitive reserve in hypometabolic subtypes of Alzheimer's disease}},
journal = {Neurobiology of aging},
year = {2024},
doi = {10.1016/j.neurobiolaging.2023.12.003},
pmid = {38157587},
url = {https://doi.org/10.1016/j.neurobiolaging.2023.12.003}
}
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Key findings
- Previous studies have demonstrated resilience to AD-related neuropathology in a form of cognitive reserve (CR).
- Typical and limbic-predominant hypometabolic subtypes demonstrated similar baseline CR, but the results suggested a faster decline of CR in the typical subtype.
- These findings support the relationship between subtypes and CR, specifically longitudinal trajectories of CR.
- Results also underline the importance of longitudinal analyses in research on CR.
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Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 38157587) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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