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Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly
Wolf H, Grunwald M, Kruggel F, Riedel-Heller SG, Angerhöfer S, Hojjatoleslami A, Hensel A, Arendt T et al.. Neurobiology of aging, 2001-03-01
Topic: Risk, prevention and care in population studies
The sensitivity of MRI volumetric measures to detect cognitive dysfunction is examined in 39 participants of an epidemiological field study (age 75-85, MMSE 19-30). According to Clinical dementia rating (CDR), 17 subjects had normal cognition (CDR 0), 12 had questionable (CDR 0.5) and 10 mild dementia (CDR 1). Discriminant analysis based on four hippocampal measures resulted in a correct classification of 76.9% of all subjects.
Key findings
- According to Clinical dementia rating (CDR), 17 subjects had normal cognition (CDR 0), 12 had questionable (CDR 0.5) and 10 mild dementia (CDR 1).
- Discriminant analysis based on four hippocampal measures resulted in a correct classification of 76.9% of all subjects.
- Left-sided and posterior hippocampal measures were more responsible for group discrimination than right-sided and anterior measures.
- In CDR 0.5, a significant hippocampal volume reduction of 14.3% vs.11.3% (left vs. right) relative to normal was found.
Why it matters
In 39 elderly participants, hippocampal volume measures correctly classified 76.9% of subjects across normal cognition, questionable dementia and mild dementia. This concerns using MRI to detect cognitive dysfunction and does not address treating, curing or preventing Alzheimer's disease.
Study details
- Participants39
- Effect size76.9%; 14.3%; 11.3%
- Evidence strengthLow
How this study scored 58/100
Published in a peer-reviewed journal, and it is a randomised controlled trial.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | 3 / 4 | Neurobiology of Aging: journal h-index 263 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2001 — older than 20 years, still counted |
| Sample size | 1 / 4 | 39 participants |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 1 / 2 | Randomised (as stated in the record) |
| Times cited | 5 / 7 | Cited 161 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 6.0 citations a year over 27 year(s) since 2001 |
| Impact for its field and year | 3 / 6 | Cited 6.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 9 other studies in this library |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author H.-J. Gertz: h-index 16 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Leipzig University: institution h-index 763 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11182467) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Wolf, H., Grunwald, M., Kruggel, F., Riedel-Heller, S. G., Angerhöfer, S., Hojjatoleslami, A., et al. (2001). Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of aging. https://doi.org/10.1016/s0197-4580(00)00238-4
Vancouver
Wolf H, Grunwald M, Kruggel F, Riedel-Heller SG, Angerhöfer S, Hojjatoleslami A, et al. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiology of aging. 2001. doi:10.1016/s0197-4580(00)00238-4. PMID: 11182467.
BibTeX
@article{wolf2001-11182467,
author = {Wolf, H. and Grunwald, M. and Kruggel, F. and Riedel-Heller, S. G. and Angerhöfer, S. and Hojjatoleslami, A. and Hensel, A. and Arendt, T. and others},
title = {{Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly}},
journal = {Neurobiology of aging},
year = {2001},
doi = {10.1016/s0197-4580(00)00238-4},
pmid = {11182467},
url = {https://doi.org/10.1016/s0197-4580(00)00238-4}
}
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