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Neurofilament Light Chain as a Potential Biomarker in Plasma for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and a Meta-Analysis
Zhenyi Fan, Xiaoxia Liu, Jie Liu, Caijing Chen, Min Zhou. Journal of integrative neuroscience, 2023-06-30
Topic: Plasma and spinal-fluid biomarkers
A total of 24 published articles that included 2397 AD and 3242 MCI patients were analysed. The level of plasma NfL was significantly increased in patients with AD and MCI when compared with healthy control subjects (standard mean difference [SMD]: 14.33 [12.42-16.24], z = 14.71, p < 0.00001; SMD: 4.95 [3.82-6.80], z = 8.59, p < 0.00001) and higher in AD patients than MCI patients (SMD: 9.32 [8.07-10.57], z = 14.62, p < 0.00001). Meta-regression analysis showed a negative relationship between Mini-Mental State Examination (MMSE) scores and plasma NfL levels in MCI patients (slope = -0.399 [95% confidence interval (CI): -0.518 to -0.281], p < 0.05). The meta-analysis suggested that NfL levels increased in the plasma of patients with AD and MCI and were associated with cognitive decline. Results provide the clinical evidence to support plasma NfL as a cognitive biomarker for AD and MCI.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Fan, Z., Liu, X., Liu, J., Chen, C., & Zhou, M. (2023). Neurofilament Light Chain as a Potential Biomarker in Plasma for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and a Meta-Analysis. Journal of integrative neuroscience. https://doi.org/10.31083/j.jin2204085
Vancouver
Fan Z, Liu X, Liu J, Chen C, Zhou M. Neurofilament Light Chain as a Potential Biomarker in Plasma for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and a Meta-Analysis. Journal of integrative neuroscience. 2023. doi:10.31083/j.jin2204085. PMID: 37519166.
BibTeX
@article{fan2023-37519166,
author = {Fan, Zhenyi and Liu, Xiaoxia and Liu, Jie and Chen, Caijing and Zhou, Min},
title = {{Neurofilament Light Chain as a Potential Biomarker in Plasma for Alzheimer's Disease and Mild Cognitive Impairment: A Systematic Review and a Meta-Analysis}},
journal = {Journal of integrative neuroscience},
year = {2023},
doi = {10.31083/j.jin2204085},
pmid = {37519166},
url = {https://doi.org/10.31083/j.jin2204085}
}
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Key findings
- A total of 24 published articles that included 2397 AD and 3242 MCI patients were analysed.
- The level of plasma NfL was significantly increased in patients with AD and MCI when compared with healthy control subjects (standard mean difference [SMD]: 14.33 [12.42-16.24], z = 14.71, p < 0.00001; SMD: 4.95 [3.82-6.80], z = 8.59, p < 0.00001) and higher in AD patients than MCI patients (SMD: 9.32 [8.07-10.57], z = 14.62, p < 0.00001).
- Meta-regression analysis showed a negative relationship between Mini-Mental State Examination (MMSE) scores and plasma NfL levels in MCI patients (slope = -0.399 [95% confidence interval (CI): -0.518 to -0.281], p < 0.05).
- The meta-analysis suggested that NfL levels increased in the plasma of patients with AD and MCI and were associated with cognitive decline.
- Results provide the clinical evidence to support plasma NfL as a cognitive biomarker for AD and MCI.
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Study details
- Study designmeta-analysis
- Participants2,397
- Evidence strengthHigh
How this study scored 80/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for effect reported because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 45 of the 56 points we could judge it on, which is 80 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of integrative neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 3 / 4 | 2,397 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37519166) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 45 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 45 of the 56 points we could judge it on is 80 out of 100. |
| Total | 80 / 100 | — |
What each of these 20 components measures, and what this score is not →
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