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Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain
Farkas E, Donka G, de Vos RA, Mihály A, Bari F, Luiten PG.. Acta neuropathologica, 2004-05-08
Topic: Brain proteins, microglia and lab models
Though cerebral white matter injury is a frequently described phenomenon in aging and dementia, the cause of white matter lesions has not been conclusively determined. Since the lesions are often associated with cerebrovascular risk factors, ischemia emerges as a potential condition for the development of white matter injury. In the present study, we induced experimental cerebral hypoperfusion by permanent, bilateral occlusion of the common carotid arteries of rats (n=6).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Farkas, E., Donka, G., de Vos, R. A., Mihály, A., Bari, F., & Luiten, P. G. (2004). Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain. Acta neuropathologica. https://doi.org/10.1007/s00401-004-0864-9
Vancouver
Farkas E, Donka G, de Vos RA, Mihály A, Bari F, Luiten PG. Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain. Acta neuropathologica. 2004. doi:10.1007/s00401-004-0864-9. PMID: 15138777.
BibTeX
@article{farkas2004-15138777,
author = {Farkas, E. and Donka, G. and de Vos, R. A. and Mihály, A. and Bari, F. and Luiten, P. G.},
title = {{Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain}},
journal = {Acta neuropathologica},
year = {2004},
doi = {10.1007/s00401-004-0864-9},
pmid = {15138777},
url = {https://doi.org/10.1007/s00401-004-0864-9}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Since the lesions are often associated with cerebrovascular risk factors, ischemia emerges as a potential condition for the development of white matter injury.
- In the present study, we induced experimental cerebral hypoperfusion by permanent, bilateral occlusion of the common carotid arteries of rats (n=6).
- A sham-operated group served as control (n=6).
- Thirteen weeks after the onset of occlusion, markers for astrocytes, microglia, and myelin were found to be labeled by means of immunocytochemistry in the corpus callosum, the internal capsule, and the optic tract.
Why it matters
In rats, permanently blocking both common carotid arteries to reduce blood flow caused white matter injury and microglial activation after thirteen weeks. This is an animal study, so it cannot yet show whether reduced brain blood flow causes white matter damage in people with dementia.
Study details
- Effect sizeincreased by 50%
- Evidence strengthLow
How this study scored 47/100
Published in a leading specialty journal. Scored zero for study design, sample size and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Acta neuropathologica) |
| Journal's citation record | 3 / 4 | Acta Neuropathologica: journal h-index 287 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2004 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rat”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 190 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 7.9 citations a year over 24 year(s) since 2004 |
| Impact for its field and year | 3 / 6 | Cited 3.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 2 / 4 | Cited 16 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Paul G.M. Luiten: h-index 61 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Groningen: institution h-index 1,383 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 15138777) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 47 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1007/s00401-004-0864-9
- PubMed: 15138777
- Original source →
- Free full text: University of Groningen research database (University of Groningen / Centre for Information Technology) →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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