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Dementia of frontal lobe type
Neary D, Snowden JS, Northen B, Goulding P.. Journal of neurology, neurosurgery, and psychiatry, 1988-03-01
Topic: Risk, prevention and care in population studies
A significant proportion of patients with presenile dementia due to primary cerebral atrophy do not have Alzheimer's disease. One form of non-Alzheimer dementia may be designated as dementia of frontal lobe type (DFT), on the basis of a characteristic neuropsychological picture suggestive of frontal lobe disorder, confirmed by findings on single photon emission tomography. The case histories of seven patients exemplify the disorder: a presentation of social misconduct and personality change, unconcern and disinhibition, in the presence of physical well-being and few neurological signs. Assessment revealed economic and concrete speech with verbal stereotypes, variable memory impairment, and marked abnormalities on tasks sensitive to frontal lobe function. Visuo-spatial disorder was invariably absent. Comparisons of DFT and Alzheimer patients revealed qualitative differences in clinical presentation, neurological signs, profile of psychological disability, electroencephalography, single photon emission tomography and demography. DFT, which may represent forms of Pick's disease, may be more common than is often recognised.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Neary, D., Snowden, J. S., Northen, B., & Goulding, P. (1988). Dementia of frontal lobe type. Journal of neurology, neurosurgery, and psychiatry. https://doi.org/10.1136/jnnp.51.3.353
Vancouver
Neary D, Snowden JS, Northen B, Goulding P. Dementia of frontal lobe type. Journal of neurology, neurosurgery, and psychiatry. 1988. doi:10.1136/jnnp.51.3.353. PMID: 3258902.
BibTeX
@article{neary1988-3258902,
author = {Neary, D. and Snowden, J. S. and Northen, B. and Goulding, P.},
title = {{Dementia of frontal lobe type}},
journal = {Journal of neurology, neurosurgery, and psychiatry},
year = {1988},
doi = {10.1136/jnnp.51.3.353},
pmid = {3258902},
url = {https://doi.org/10.1136/jnnp.51.3.353}
}
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Key findings
- A significant proportion of patients with presenile dementia due to primary cerebral atrophy do not have Alzheimer's disease.
- Assessment revealed economic and concrete speech with verbal stereotypes, variable memory impairment, and marked abnormalities on tasks sensitive to frontal lobe function.
- Comparisons of DFT and Alzheimer patients revealed qualitative differences in clinical presentation, neurological signs, profile of psychological disability, electroencephalography, single photon emission tomography and demography.
Why it matters
This study describes seven patients with dementia of frontal lobe type, a non-Alzheimer dementia with social misconduct, personality change, and frontal lobe test abnormalities, and compares them with Alzheimer patients. It characterizes a different form of dementia and does not test any treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 45/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neurology, neurosurgery, and psychiatry) |
| Journal's citation record | 3 / 4 | Journal of Neurology Neurosurgery & Psychiatry: journal h-index 336 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1988 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (pubmed indexes it as a clinical or observational study) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 558 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 13.9 citations a year over 40 year(s) since 1988 |
| Impact for its field and year | 4 / 6 | Cited 11.6× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 22 other studies in this library |
| Still being cited | 1 / 4 | Cited 12 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Peter Goulding: h-index 19 (OpenAlex, whole career) |
| Institution's track record | 0 / 3 | Manchester Royal Infirmary: institution h-index 399 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 3258902) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 45 / 100 | — |
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Read the original
- DOI: 10.1136/jnnp.51.3.353
- PubMed: 3258902
- Original source →
- Free full text: Journal of Neurology Neurosurgery & Psychiatry →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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