Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies
Kurz C, Walker L, Rauchmann BS, Perneczky R.. Neuropathology and applied neurobiology, 2022-02-02
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Improved insight into these pathomechanisms may allow to shed light on the role of Aβ deposition as a primary versus a secondary event in the complex pathogenesis of AD.
What this study adds
Evidence grade: High
This is a pooled review. This review of human studies examines evidence of blood-brain barrier dysfunction in Alzheimer's disease and how it may relate to amyloid deposition. It is a summary of research that may inform understanding of the disease process, not a treatment or cure.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Kurz, C., Walker, L., Rauchmann, B. S., & Perneczky, R. (2022). Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies. Neuropathology and applied neurobiology. https://doi.org/10.1111/nan.12782
Vancouver
Kurz C, Walker L, Rauchmann BS, Perneczky R. Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies. Neuropathology and applied neurobiology. 2022. doi:10.1111/nan.12782. PMID: 34823269.
BibTeX
@article{kurz2022-34823269,
author = {Kurz, C. and Walker, L. and Rauchmann, B. S. and Perneczky, R.},
title = {{Dysfunction of the blood-brain barrier in Alzheimer's disease: Evidence from human studies}},
journal = {Neuropathology and applied neurobiology},
year = {2022},
doi = {10.1111/nan.12782},
pmid = {34823269},
url = {https://doi.org/10.1111/nan.12782}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Improved insight into these pathomechanisms may allow to shed light on the role of Aβ deposition as a primary versus a secondary event in the complex pathogenesis of AD.
Why it matters
This review of human studies examines evidence of blood-brain barrier dysfunction in Alzheimer's disease and how it may relate to amyloid deposition. It is a summary of research that may inform understanding of the disease process, not a treatment or cure.
New to this subject? Start with our plain-English guide: Genetics →
Study details
- Study designmeta-analysis
- Evidence strengthHigh
How this study scored 64/100
Published in a peer-reviewed journal, and it is a meta-analysis pooling many studies. Scored zero for sample size, effect reported and studied in people because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuropathology and applied neurobiology) |
| Journal's citation record | 1 / 4 | Neuropathology and Applied Neurobiology: journal h-index 143 (OpenAlex, 2026-10-29) |
| Study design | 12 / 12 | A meta-analysis pooling many studies |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | A review of other studies — randomization is not credited here |
| Times cited | 5 / 7 | Cited 181 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 30.2 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 3 / 6 | Cited 7.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 132 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Robert Perneczky: h-index 73 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Imperial College London: institution h-index 1,744 (OpenAlex) |
| Multicenter collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 34823269) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
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