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Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease
Li C, Zhao R, Gao K, Wei Z, Yin MY, Lau LT, Chui D, Yu AC.. Current Alzheimer research, 2011-02-01
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is a neurodegenerative disease with major clinical hallmarks of memory loss, dementia, and cognitive impairment. Neuroinflammation is involved in the onset of several neurodegenerative disorders. Astrocyte is the most abundant type of glial cells in the central nervous system (CNS) and appears to be involved in the induction of neuroinflammation.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Li, C., Zhao, R., Gao, K., Wei, Z., Yin, M. Y., Lau, L. T., et al. (2011). Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease. Current Alzheimer research. https://doi.org/10.2174/156720511794604543
Vancouver
Li C, Zhao R, Gao K, Wei Z, Yin MY, Lau LT, et al. Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease. Current Alzheimer research. 2011. doi:10.2174/156720511794604543. PMID: 21143158.
BibTeX
@article{li2011-21143158,
author = {Li, C. and Zhao, R. and Gao, K. and Wei, Z. and Yin, M. Y. and Lau, L. T. and Chui, D. and Yu, A. C.},
title = {{Astrocytes: implications for neuroinflammatory pathogenesis of Alzheimer's disease}},
journal = {Current Alzheimer research},
year = {2011},
doi = {10.2174/156720511794604543},
pmid = {21143158},
url = {https://doi.org/10.2174/156720511794604543}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Neuroinflammation is involved in the onset of several neurodegenerative disorders.
- Astrocyte is the most abundant type of glial cells in the central nervous system (CNS) and appears to be involved in the induction of neuroinflammation.
- Under stress and injury, astrocytes become astrogliotic leading to an upregulation of the expression of proinflammatory cytokines and chemokines, which are associated with the pathogenesis of AD.
- Cytokines and related molecules play roles in both neuroprotection and neurodegeneration in the CNS.
Why it matters
This review discusses astrocytes and their possible involvement in the neuroinflammatory pathogenesis of Alzheimer's disease, noting that cytokines can play both neuroprotective and other roles. It offers no treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Current Alzheimer research) |
| Journal's citation record | 1 / 4 | Current Alzheimer Research: journal h-index 119 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 289 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 17.0 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 4 / 6 | Cited 13.5× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 2 / 4 | Cited 20 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Albert Cheung Hoi Yu: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Peking University: institution h-index 1,098 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21143158) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
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