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Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease
Al-Ghraiybah NF, Wang J, Alkhalifa AE, Roberts AB, Raj R, Yang E, Kaddoumi A.. International journal of molecular sciences, 2022-09-12
Topic: Amyloid, tau and blood-test diagnosis
Alzheimer's disease (AD) is a progressive neurodegenerative disorder; it is the most common cause of dementia and has no treatment. It is characterized by two pathological hallmarks, the extracellular deposits of amyloid beta (Aβ) and the intraneuronal deposits of Neurofibrillary tangles (NFTs). Yet, those two hallmarks do not explain the full pathology seen with AD, suggesting the involvement of other mechanisms.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Al-Ghraiybah, N. F., Wang, J., Alkhalifa, A. E., Roberts, A. B., Raj, R., Yang, E., et al. (2022). Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease. International journal of molecular sciences. https://doi.org/10.3390/ijms231810572
Vancouver
Al-Ghraiybah NF, Wang J, Alkhalifa AE, Roberts AB, Raj R, Yang E, et al. Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease. International journal of molecular sciences. 2022. doi:10.3390/ijms231810572. PMID: 36142483.
BibTeX
@article{alghraiybah2022-36142483,
author = {Al-Ghraiybah, N. F. and Wang, J. and Alkhalifa, A. E. and Roberts, A. B. and Raj, R. and Yang, E. and Kaddoumi, A.},
title = {{Glial Cell-Mediated Neuroinflammation in Alzheimer's Disease}},
journal = {International journal of molecular sciences},
year = {2022},
doi = {10.3390/ijms231810572},
pmid = {36142483},
url = {https://doi.org/10.3390/ijms231810572}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- It is characterized by two pathological hallmarks, the extracellular deposits of amyloid beta (Aβ) and the intraneuronal deposits of Neurofibrillary tangles (NFTs).
- Yet, those two hallmarks do not explain the full pathology seen with AD, suggesting the involvement of other mechanisms.
- Neuroinflammation could offer another explanation for the progression of the disease.
- This review provides an overview of recent advances on the role of the immune cells' microglia and astrocytes in neuroinflammation.
Why it matters
This review discusses the role of microglia and astrocytes in neuroinflammation in Alzheimer's disease and suggests neuroinflammation may help explain disease progression beyond amyloid and tau. It is a summary of existing research and reports no new treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (International journal of molecular sciences) |
| Journal's citation record | 3 / 4 | International Journal of Molecular Sciences: journal h-index 426 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 200 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 33.3 citations a year over 6 year(s) since 2022 |
| Impact for its field and year | 4 / 6 | Cited 10.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 3 / 4 | Cited 177 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Amal Kaddoumi: h-index 45 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | The Ohio State University: institution h-index 1,378 (OpenAlex) |
| Multicenter collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 36142483) |
| Free to read | 2 / 2 | Free to read |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3390/ijms231810572
- PubMed: 36142483
- Original source →
- Free full text: International Journal of Molecular Sciences →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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